Improvement of cognitive function in Alzheimer's disease model mice by genetic and pharmacological inhibition of the EP(4) receptor. (Q51848808)

14 April 2018

title

Improvement of cognitive function in Alzheimer's disease model mice by genetic and pharmacological inhibition of the EP(4) receptor. (English)

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Shuh Narumiya

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author name string

Tatsuya Hoshino

1

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Takushi Namba

2

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Masaya Takehara

3

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Naoya Murao

4

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Takahide Matsushima

5

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Yukihiko Sugimoto

6

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Toshiharu Suzuki

8

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Tohru Mizushima

9

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language of work or name

English

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publication date

23 January 2012

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Journal of Neurochemistry

published in

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volume

120

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issue

5

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page(s)

795-805

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Bidirectional trafficking of prostaglandin E2 receptors involved in long-term potentiation in visual cortex.

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Expression of prostaglandin E2 receptor subtypes, EP2 and EP4, in the rat hippocampus after cerebral ischemia and ischemic tolerance

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Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

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Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice

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Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease

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Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo

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Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor.

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Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function.

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Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury.

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The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut

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Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease

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Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-gamma in Alzheimer's disease brains

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Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity

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Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease.

21 January 2018

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Pathways towards and away from Alzheimer's disease

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Cyclooxygenase (COX)-2 and COX-1 Potentiate β-Amyloid Peptide Generation through Mechanisms That Involve γ-Secretase Activity

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Cardiovascular toxicity of valdecoxib

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Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

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Impaired cognition, sensorimotor gating, and hippocampal long-term depression in mice lacking the prostaglandin E2 EP2 receptor

21 January 2018

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Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology

21 January 2018

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The prostaglandin E2 E-prostanoid 4 receptor exerts anti-inflammatory effects in brain innate immunity

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Merck withdraws arthritis drug worldwide

21 January 2018

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gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

21 January 2018

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Pharmacological analysis of cyclooxygenase-1 in inflammation

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Roles of prostaglandin E-receptor subtypes in gastric and duodenal bicarbonate secretion in rats.

21 January 2018

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Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen

21 January 2018

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Identification of EP4 as a potential target for the treatment of castration-resistant prostate cancer using a novel xenograft model

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Age-dependent cognitive decline in the APP23 model precedes amyloid deposition

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Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling

21 January 2018

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Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion

21 January 2018

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Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation

21 January 2018

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Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

21 January 2018

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10.1111/J.1471-4159.2011.07567.X

21 January 2018

Identifiers

DOI

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14 April 2018

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14 April 2018