Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4+ CD25- LAP+ T cells. (Q51807517)

12 April 2018

title

Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4+ CD25- LAP+ T cells. (English)

1 reference

12 April 2018

1 reference

12

Howard L Weiner

1 reference

12 April 2018

author name string

Hirofumi Ochi

1

1 reference

12 April 2018

Michal Abraham

2

1 reference

12 April 2018

Hiroki Ishikawa

3

1 reference

12 April 2018

Dan Frenkel

4

1 reference

12 April 2018

Kaiyong Yang

5

1 reference

12 April 2018

Alexandre S Basso

6

1 reference

12 April 2018

Henry Wu

7

1 reference

12 April 2018

Mei-Ling Chen

8

1 reference

12 April 2018

Roopali Gandhi

9

1 reference

12 April 2018

Ariel Miller

10

1 reference

12 April 2018

Ruth Maron

11

1 reference

12 April 2018

language of work or name

English

0 references

publication date

21 May 2006

1 reference

12 April 2018

published in

Nature Medicine

1 reference

12 April 2018

volume

12

1 reference

12 April 2018

issue

6

1 reference

12 April 2018

page(s)

627-635

1 reference

12 April 2018

https://scigraph.springernature.com/pub.10.1038/nm1408

exact match

0 references

cites work

Prevention of autoimmune diabetes with nonactivating anti-CD3 monoclonal antibody

1 reference

Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice

21 January 2018

1 reference

Remission and pancreas isograft survival in recent onset diabetic NOD mice after treatment with low-dose anti-CD3 monoclonal antibodies

21 January 2018

1 reference

Nonmitogenic CD3 antibody reverses virally induced (rat insulin promoter-lymphocytic choriomeningitis virus) autoimmune diabetes without impeding viral clearance

21 January 2018

1 reference

TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes.

21 January 2018

1 reference

Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus

21 January 2018

1 reference

Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3gamma1(Ala-Ala).

21 January 2018

1 reference

Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes

21 January 2018

1 reference

TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs

21 January 2018

1 reference

A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes

21 January 2018

1 reference

Human in vivo antigenic modulation induced by the anti-T cell OKT3 monoclonal antibody.

21 January 2018

1 reference

CD3-specific antibody-induced active tolerance: from bench to bedside

21 January 2018

1 reference

Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin

21 January 2018

1 reference

Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice

21 January 2018

1 reference

Nasal vaccination with myelin oligodendrocyte glycoprotein reduces stroke size by inducing IL-10-producing CD4+ T cells

21 January 2018

1 reference

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering

21 January 2018

1 reference

Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis

21 January 2018

1 reference

Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta

21 January 2018

1 reference

TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice

21 January 2018

1 reference

Induction of immunity and oral tolerance with polymorphic class II major histocompatibility complex allopeptides in the rat

21 January 2018

1 reference

Regulatory Th2-type T cell lines against insulin and GAD peptides derived from orally- and nasally-treated NOD mice suppress diabetes

21 January 2018

1 reference

Induction of anergy or active suppression following oral tolerance is determined by antigen dosage.

21 January 2018

1 reference

Peripheral deletion of antigen-reactive T cells in oral tolerance.

21 January 2018

1 reference

Role of TCR-induced extracellular signal-regulated kinase activation in the regulation of early IL-4 expression in naive CD4+ T cells

21 January 2018

1 reference

Regulation of naive T cell differentiation by varying the potency of TCR signal transduction

21 January 2018

1 reference

Recovery from experimental allergic encephalomyelitis is TGF-beta dependent and associated with increases in CD4+LAP+ and CD4+CD25+ T cells.

21 January 2018

1 reference

An open trial of OKT3 in patients with multiple sclerosis

21 January 2018

1 reference

Reversal of experimental allergic encephalomyelitis with non-mitogenic, non-depleting anti-CD3 mAb therapy with a preferential effect on T(h)1 cells that is augmented by IL-4

21 January 2018

1 reference

7 January 2021

Treatment with nonmitogenic anti-CD3 monoclonal antibody induces CD4+ T cell unresponsiveness and functional reversal of established experimental autoimmune encephalomyelitis

1 reference

7 January 2021

1 reference

7 January 2021

Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration

1 reference

7 January 2021

CD4+CD25- T cells that express latency-associated peptide on the surface suppress CD4+CD45RBhigh-induced colitis by a TGF-beta-dependent mechanism

1 reference

7 January 2021

IL-4 is a differentiation factor for transforming growth factor-beta secreting Th3 cells and oral administration of IL-4 enhances oral tolerance in experimental allergic encephalomyelitis

1 reference

7 January 2021

Mucosal administration of IL-10 enhances oral tolerance in autoimmune encephalomyelitis and diabetes

1 reference

7 January 2021

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4,

1 reference

7 January 2021

Identifiers

DOI

10.1038/NM1408

1 reference

12 April 2018

PubMed ID

16715091

1 reference

12 April 2018