Generation and characterization of RAG2 knockout pigs as animal model for severe combined immunodeficiency. (Q51590743)

7 April 2018

title

Generation and characterization of RAG2 knockout pigs as animal model for severe combined immunodeficiency. (English)

1 reference

7 April 2018

severe combined immunodeficiency

main subject

1 reference

Shunichi Suzuki

1

1 reference

7 April 2018

Masaki Iwamoto

2

1 reference

7 April 2018

Michiko Hashimoto

3

1 reference

7 April 2018

Misae Suzuki

4

1 reference

7 April 2018

Michiko Nakai

5

1 reference

7 April 2018

Daiichiro Fuchimoto

6

1 reference

7 April 2018

Shoichiro Sembon

7

1 reference

7 April 2018

Tomoko Eguchi-Ogawa

8

1 reference

7 April 2018

Hirohide Uenishi

9

1 reference

7 April 2018

Akira Onishi

10

1 reference

7 April 2018

publication date

30 June 2016

1 reference

7 April 2018

Veterinary Immunology and Immunopathology

published in

1 reference

7 April 2018

volume

178

1 reference

7 April 2018

page(s)

37-49

1 reference

7 April 2018

The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Human immune responses and potential for vaccine assessment in humanized mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Generation of a humanized mouse model with both human immune system and liver cells to model hepatitis C virus infection and liver immunopathogenesis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Hepatitis B virus infection and immunopathogenesis in a humanized mouse model: induction of human-specific liver fibrosis and M2-like macrophages

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Human B cells express a CD45 isoform that is similar to murine B220 and is downregulated with acquisition of the memory B-cell marker CD27.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

B220: a B cell-specific member of th T200 glycoprotein family

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Lessons from human teratomas to guide development of safe stem cell therapies.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Genomic structure of the whole D-J-C clusters and the upstream region coding V segments of the TRB locus in pig

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Antibody repertoire development in fetal and neonatal piglets. XI. The relationship of variable heavy chain gene usage and the genomic organization of the variable heavy chain locus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Genetically modified pig models for human diseases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Porcine T lymphocytes and NK cells--an update.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

RAG1/2 knockout pigs with severe combined immunodeficiency

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Autoantigen-Specific Interactions with CD4+ Thymocytes Control Mature Medullary Thymic Epithelial Cell Cellularity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Generation of recombination activating gene-1-deficient neonatal piglets: a model of T and B cell deficient severe combined immune deficiency

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

New insights into the proliferation and differentiation of early mouse thymocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Engraftment of human iPS cells and allogeneic porcine cells into pigs with inactivated RAG2 and accompanying severe combined immunodeficiency

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Identification of the earliest B lineage stage in mouse bone marrow

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Of mice and not men: differences between mouse and human immunology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

RAG-1-deficient mice have no mature B and T lymphocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Pig cloning by microinjection of fetal fibroblast nuclei.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Genetically engineered pig models for human diseases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Development of secondary lymphoid organs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

RAG mutations in human B cell-negative SCID.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Genomic responses in mouse models poorly mimic human inflammatory diseases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Human cancer growth and therapy in immunodeficient mouse models

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

B cell lymphogenesis in swine is located in the bone marrow.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Early ontogeny of thymocytes in pigs: sequential colonization of the thymus by T cell progenitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Genomic structure and gene order of swine chromosome 7q1.1-->q1.2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Development of a human adaptive immune system in cord blood cell-transplanted mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Genomic sequence encoding diversity segments of the pig TCR delta chain gene demonstrates productivity of highly diversified repertoire

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Generation of interleukin-2 receptor gamma gene knockout pigs from somatic cells genetically modified by zinc finger nuclease-encoding mRNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

Definition of the specificity of monoclonal antibodies against porcine CD45 and CD45R: report from the CD45/CD45R and CD44 subgroup of the Second International Swine CD Workshop.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VETIMM.2016.06.011

10.1016/J.VETIMM.2016.06.011

7 January 2021

Identifiers

DOI

1 reference

7 April 2018

PubMed ID

27496741

1 reference

7 April 2018