Phospholipases A2 mediate amyloid-beta peptide-induced mitochondrial dysfunction. (Q51113387)

http://europepmc.org/abstract/MED/17065451

30 March 2018

title

Phospholipases A2 mediate amyloid-beta peptide-induced mitochondrial dysfunction (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674660&resulttype=core&format=json

11 May 2020

1

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Yinzhi Lai

2

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11 May 2020

author name string

Phullara B Shelat

3

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11 May 2020

Chunhua Hu

4

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Grace Y Sun

5

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James C-M Lee

6

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11 May 2020

language of work or name

English

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publication date

1 October 2006

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http://europepmc.org/abstract/MED/17065451

30 March 2018

published in

Journal of Neuroscience

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volume

26

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page(s)

11111-11119

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issue

43

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Regulation and inhibition of phospholipase A2.

11 May 2020

cites work

1 reference

12 December 2020

Cytosolic phospholipase A2 is induced in reactive glia following different forms of neurodegeneration.

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12 December 2020

Mitochondrial depolarization is not required for neuronal apoptosis.

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12 December 2020

Studies on the cytosolic phospholipase A2 in immortalized astrocytes (DITNC) revealed new properties of the calcium ionophore, A23187.

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12 December 2020

Elevated oxidative stress in models of normal brain aging and Alzheimer's disease

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In vitro and in vivo oxidative stress associated with Alzheimer's amyloid beta-peptide (1-42)

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12 December 2020

Oxidative stress and Alzheimer disease

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Preservation of mitochondrial structure and function after Bid- or Bax-mediated cytochrome c release

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Amyloid beta-peptide disrupts mitochondrial membrane lipid and protein structure: protective role of tauroursodeoxycholate.

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12 December 2020

Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic process

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12 December 2020

Clearing the brain's amyloid cobwebs

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12 December 2020

Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities

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12 December 2020

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12 December 2020

Generation of reactive oxygen species by the mitochondrial electron transport chain

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12 December 2020

Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

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12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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12 December 2020

Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling.

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12 December 2020

Role of PKC and MAPK in cytosolic PLA2 phosphorylation and arachadonic acid release in primary murine astrocytes

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12 December 2020

Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review

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12 December 2020

Oxidant-mediated AA release from astrocytes involves cPLA(2) and iPLA(2).

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12 December 2020

Relative mitochondrial membrane potential and [Ca2+]i in type I cells isolated from the rabbit carotid body

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12 December 2020

Cerebrometabolic abnormalities in Alzheimer's disease

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12 December 2020

Phospholipase A2, Hydroxyl Radicals, and Lipid Peroxidation in Transient Cerebral Ischemia

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12 December 2020

Phospholipase A2 in the central nervous system: implications for neurodegenerative diseases

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12 December 2020

Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase.

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12 December 2020

Toxicity of amyloid beta peptide: tales of calcium, mitochondria, and oxidative stress

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12 December 2020

Arachidonic acid released by phospholipase A(2) activation triggers Ca(2+)-dependent apoptosis through the mitochondrial pathway

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12 December 2020

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.

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12 December 2020

Apocynin prevents cyclooxygenase 2 expression in human monocytes through NADPH oxidase and glutathione redox-dependent mechanisms

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12 December 2020

Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis

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12 December 2020

Cytosolic phospholipase A2 mediates neuronal apoptosis induced by soluble oligomers of the amyloid-beta peptide

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12 December 2020

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

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12 December 2020

Mitochondrial failures in Alzheimer's disease

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12 December 2020

ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction

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12 December 2020

Mitochondrial abnormalities in Alzheimer brain: mechanistic implications

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12 December 2020

Hydrogen peroxide alters membrane and cytoskeleton properties and increases intercellular connections in astrocytes.

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12 December 2020

Activation of calcium-independent phospholipase A (iPLA) in brain mitochondria and release of apoptogenic factors by BAX and truncated BID.

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12 December 2020

Induction of reactive oxygen species by bisphenol A and abrogation of bisphenol A-induced cell injury by DJ-1.

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12 December 2020

A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease

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12 December 2020

Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease.

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12 December 2020

Oxidative stress: the old enemy in Alzheimer's disease pathophysiology

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12 December 2020

Amyloid precursor protein-mediated free radicals and oxidative damage: implications for the development and progression of Alzheimer's disease

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12 December 2020

Physicochemical characteristics of soluble oligomeric Abeta and their pathologic role in Alzheimer's disease.

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12 December 2020

Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration

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12 December 2020

Acute effect of fatty acids on metabolism and mitochondrial coupling in skeletal muscle.

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12 December 2020

Mitochondrial iPLA2 activity modulates the release of cytochrome c from mitochondria and influences the permeability transition.

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12 December 2020

Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis

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12 December 2020

Interaction of free fatty acids with mitochondria: coupling, uncoupling and permeability transition

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12 December 2020

Oxidative stress in Alzheimer's disease

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12 December 2020

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue

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12 December 2020

Suppression of mitochondrial succinate dehydrogenase, a primary target of beta-amyloid, and its derivative racemized at Ser residue.

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12 December 2020

Properties and regulation of cytosolic phospholipase A2.

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12 December 2020

Activation of liver mitochondrial phospholipase A2 by superoxide

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12 December 2020

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.

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12 December 2020

The central executioners of apoptosis: caspases or mitochondria?

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12 December 2020

Mitochondria and apoptosis

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12 December 2020

Abnormalities of mitochondrial enzymes in Alzheimer disease.

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12 December 2020

10.1523/JNEUROSCI.3505-06.2006

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674660&resulttype=core&format=json

11 May 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674660&resulttype=core&format=json

11 May 2020

1 reference