Homotypic and heterotypic interactions of EWS, FLI1 and their oncogenic fusion protein. (Q50767221)

18 March 2018

title

Homotypic and heterotypic interactions of EWS, FLI1 and their oncogenic fusion protein. (English)

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18 March 2018

author

Johannes A. Schmid

4

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18 March 2018

Heinrich Kovar

6

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18 March 2018

author name string

Laura Spahn

1

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18 March 2018

Christine Siligan

2

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18 March 2018

Radostina Bachmaier

3

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18 March 2018

Dave N T Aryee

5

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18 March 2018

language of work or name

English

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publication date

1 October 2003

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18 March 2018

published in

Oncogene

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18 March 2018

volume

22

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18 March 2018

issue

44

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18 March 2018

page(s)

6819-6829

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18 March 2018

https://scigraph.springernature.com/pub.10.1038/sj.onc.1206810

exact match

0 references

cites work

EWS/FLI1 up regulates mE2-C, a cyclin-selective ubiquitin conjugating enzyme involved in cyclin B destruction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206810

DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206810

EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes.

21 January 2018

1 reference

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Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206810

Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2and c-Myc expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206810

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206810

The prooncoprotein EWS binds calmodulin and is phosphorylated by protein kinase C through an IQ domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206810

Tyrosine kinase Pyk2 mediates G-protein-coupled receptor regulation of the Ewing sarcoma RNA-binding protein EWS

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206810

A repetitive element containing a critical tyrosine residue is required for transcriptional activation by the EWS/ATF1 oncogene

21 January 2018

1 reference

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Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma

21 January 2018

1 reference

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EWS-FLI1 and EWS-ERG gene fusions are associated with similar clinical phenotypes in Ewing's sarcoma.

21 January 2018

1 reference

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The SH3 domain of Bruton's tyrosine kinase interacts with Vav, Sam68 and EWS

21 January 2018

1 reference

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Transforming activity of EWS/FLI is not strictly dependent upon DNA-binding activity

21 January 2018

1 reference

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Modification of EWS/WT1 functional properties by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206810

Modulation of EWS/WT1 activity by the v-Src protein tyrosine kinase

21 January 2018

1 reference

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Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50

21 January 2018

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The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression

21 January 2018

1 reference

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The splicing factor U1C represses EWS/FLI-mediated transactivation

21 January 2018

1 reference

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EWS/FLI alters 5'-splice site selection

21 January 2018

1 reference

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The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts

21 January 2018

1 reference

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Transcriptional activation by the Ewing's sarcoma (EWS) oncogene can be cis-repressed by the EWS RNA-binding domain

21 January 2018

1 reference

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Regulation of Ets function by protein - protein interactions

21 January 2018

1 reference

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Downregulation and forced expression of EWS-Fli1 fusion gene results in changes in the expression of G(1)regulatory genes.

21 January 2018

1 reference

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Proteins of the ETS family with transcriptional repressor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206810

EWS/FLI1-induced manic fringe renders NIH 3T3 cells tumorigenic

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206810

Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206810

Phosphorylation of the EWS IQ domain regulates transcriptional activity of the EWS/ATF1 and EWS/FLI1 fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206810

Oncogenic EWS-Fli1 interacts with hsRPB7, a subunit of human RNA polymerase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206810

Oligomerization of the human serotonin transporter and of the rat GABA transporter 1 visualized by fluorescence resonance energy transfer microscopy in living cells.

21 January 2018

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Fluorescence resonance energy transfer in the study of cancer pathways

21 January 2018

1 reference

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A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206810

Inhibition of EWS-FLI-1 fusion protein with antisense oligodeoxynucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206810

DNA binding domain-independent pathways are involved in EWS/FLI1-mediated oncogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206810

Reliable and global measurement of fluorescence resonance energy transfer using fluorescence microscopes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206810

The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206810

PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206810

EWS.Fli-1 fusion protein interacts with hyperphosphorylated RNA polymerase II and interferes with serine-arginine protein-mediated RNA splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206810

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7 January 2021

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Identifiers

DOI

10.1038/SJ.ONC.1206810

1 reference

18 March 2018

PubMed ID

14534527

1 reference

18 March 2018