Casein kinase 2 alpha 1 (Q5048395)

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mammalian protein found in Homo sapiens
  • CK2 catalytic subunit alpha
  • CK II alpha 3
  • CSNK2A3
  • casein kinase II alpha 1 subunit
  • casein kinase II alpha 1 polypeptide pseudogene
  • casein kinase II subunit alpha
  • CKII
  • CK2A1
  • protein kinase CK2
  • CSNK2A1
  • casein kinase 2, alpha 1 polypeptide
edit
Language Label Description Also known as
English
Casein kinase 2 alpha 1
mammalian protein found in Homo sapiens
  • CK2 catalytic subunit alpha
  • CK II alpha 3
  • CSNK2A3
  • casein kinase II alpha 1 subunit
  • casein kinase II alpha 1 polypeptide pseudogene
  • casein kinase II subunit alpha
  • CKII
  • CK2A1
  • protein kinase CK2
  • CSNK2A1
  • casein kinase 2, alpha 1 polypeptide

Statements

molecular function
protein serine/threonine kinase activity
determination method
IDA
IEA
IMP
TAS
8 references
retrieved
17 October 2017
stated in
Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II
GOA
curator
UniProt
UniProt protein ID
P68400
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P68400&geneProductId=UniProtKB:P68400
determination method
TAS
retrieved
17 October 2017
stated in
The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation
GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P68400&geneProductId=UniProtKB:P68400
determination method
IMP
retrieved
17 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P68400
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P68400&geneProductId=UniProtKB:P68400
determination method
IEA
retrieved
17 October 2017
stated in
Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8
GOA
curator
UniProt
UniProt protein ID
P68400
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P68400&geneProductId=UniProtKB:P68400
determination method
IDA
retrieved
17 October 2017
stated in
Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer
GOA
curator
UniProt
UniProt protein ID
P68400
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P68400&geneProductId=UniProtKB:P68400
determination method
IDA
retrieved
17 October 2017
stated in
CK2 phosphorylation of the armadillo repeat region of beta-catenin potentiates Wnt signaling
GOA
curator
UniProt
UniProt protein ID
P68400
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P68400&geneProductId=UniProtKB:P68400
determination method
IDA
retrieved
17 October 2017
stated in
CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P68400&geneProductId=UniProtKB:P68400
determination method
IDA
retrieved
17 October 2017
stated in
Interactions of the HIV-1 Tat and RAP74 proteins with the RNA polymerase II CTD phosphatase FCP1
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P68400&geneProductId=UniProtKB:P68400
determination method
IDA
protein binding
determination method
IPI
32 references
retrieved
8 April 2019
stated in
Phosphorylation by protein kinase CK2: a signaling switch for the caspase-inhibiting protein ARC
GOA
curator
UniProt
UniProt protein ID
P68400
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer
GOA
curator
UniProt
UniProt protein ID
P68400
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA
GOA
curator
UniProt
UniProt protein ID
P68400
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
Transcription factor TAFII250 phosphorylates the acidic domain of Mdm2 through recruitment of protein kinase CK2
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
p53 deacetylation by SIRT1 decreases during protein kinase CKII downregulation-mediated cellular senescence
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
KIF5C: a new binding partner for protein kinase CK2 with a preference for the CK2alpha' subunit
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
Protein kinase CK2 triggers cytosolic zinc signaling pathways by phosphorylation of zinc channel ZIP7
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
An AUTS2-Polycomb complex activates gene expression in the CNS.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
Interactions of protein kinase CK2beta subunit within the holoenzyme and with other proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
A High-Density Map for Navigating the Human Polycomb Complexome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
A "twist box" code of p53 inactivation: twist box: p53 interaction promotes p53 degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of Grb14 BPS domain by GSK-3 correlates with complex forming of Grb14 and insulin receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
The functional interactome landscape of the human histone deacetylase family
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
Next-generation sequencing to generate interactome datasets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
A CK2-dependent mechanism for degradation of the PML tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
retrieved
8 April 2019
stated in
A bead-based approach for large-scale identification of in vitro kinase substrates
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IPI
protein serine/threonine kinase activity
determination method
IDA
IEA
IGI
IMP
TAS
9 references
retrieved
8 April 2019
stated in
Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II
GOA
curator
UniProt
UniProt protein ID
P68400
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
TAS
retrieved
8 April 2019
stated in
The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation
GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IMP
retrieved
8 April 2019
stated in
Protein kinase CK2 modulates HSJ1 function through phosphorylation of the UIM2 domain
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IGI
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P68400
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IEA
retrieved
8 April 2019
stated in
Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8
GOA
curator
UniProt
UniProt protein ID
P68400
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IDA
retrieved
8 April 2019
stated in
Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer
GOA
curator
UniProt
UniProt protein ID
P68400
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IDA
retrieved
8 April 2019
stated in
CK2 phosphorylation of the armadillo repeat region of beta-catenin potentiates Wnt signaling
GOA
curator
UniProt
UniProt protein ID
P68400
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IDA
retrieved
8 April 2019
stated in
CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IDA
retrieved
8 April 2019
stated in
Interactions of the HIV-1 Tat and RAP74 proteins with the RNA polymerase II CTD phosphatase FCP1
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68400
determination method
IDA
cell component
biological process
Gene Atlas image
PBB GE CSNK2A1 212072 s at fs.png
732 × 530; 12 KB
0 references

Identifiers

Ensembl protein ID
PDB structure ID
 
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