Cyclin dependent kinase inhibitor 1B (Q5009962)

http://www.ebi.ac.uk/interpro/protein/P46527

1 reference

13 November 2019

1 reference

13 November 2019

36 references

10 September 2018

Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Role of T198 modification in the regulation of p27(Kip1) protein stability and function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

The cell cycle regulator p27Kip1 interacts with MCM7, a DNA replication licensing factor, to inhibit initiation of DNA replication

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Acetylation-dependent regulation of Skp2 function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Towards a proteome-scale map of the human protein–protein interaction network

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Cyclin-binding motifs are essential for the function of p21CIP1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Thioredoxin modulates activator protein 1 (AP-1) activity and p27Kip1 degradation through direct interaction with Jab1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

C-terminal phosphorylation controls the stability and function of p27kip1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

New functional activities for the p21 family of CDK inhibitors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

A NIK-IKKα module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Widespread macromolecular interaction perturbations in human genetic disorders

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

The protein interaction landscape of the human CMGC kinase group

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

protein phosphatase binding

1 reference

5 June 2018

Knockdown of protein tyrosine phosphatase SHP-1 inhibits G1/S progression in prostate cancer cells through the regulation of components of the cell-cycle machinery

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

cyclin-dependent protein serine/threonine kinase activity

1 reference

10 September 2018

Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding

EXP

protein kinase binding

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

1 reference

10 September 2018

p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

cyclin-dependent protein serine/threonine kinase inhibitor activity

5 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

5 June 2018

PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

5 June 2018

Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

Hsp70 protein binding

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

protein-containing complex binding

3 references

5 June 2018

p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

5 June 2018

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

cyclin-dependent protein serine/threonine kinase inhibitor activity

6 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

protein kinase binding

protein phosphatase binding

protein-containing complex binding

4 references

10 September 2018

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

4 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

5 June 2018

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

Cul4A-RING E3 ubiquitin ligase complex

1 reference

5 June 2018

Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

6 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

5 June 2018

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

5 June 2018

Immunohistochemical analysis of p18INK4C and p14ARF protein expression in 117 oligodendrogliomas: correlation with tumor grade and clinical outcome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

intracellular membrane-bounded organelle

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

protein-containing complex

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

7 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Immunohistochemical analysis of p18INK4C and p14ARF protein expression in 117 oligodendrogliomas: correlation with tumor grade and clinical outcome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

5 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

Cul4A-RING E3 ubiquitin ligase complex

Notch signaling pathway

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

regulation of cyclin-dependent protein serine/threonine kinase activity

1 reference

10 September 2018

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

response to estradiol

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

positive regulation of cell death

1 reference

10 September 2018

Nkx3.1 and p27(KIP1) cooperate in proliferation inhibition and apoptosis induction in human androgen-independent prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

response to amino acid

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

response to cadmium ion

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

positive regulation of protein catabolic process

1 reference

5 June 2018

A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

response to organic cyclic compound

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

cellular response to lithium ion

1 reference

10 September 2018

A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

cellular response to organic cyclic compound

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

response to peptide hormone

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

negative regulation of apoptotic process

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

sensory perception of sound

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

potassium ion transport

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

regulation of cell population proliferation

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

negative regulation of cell growth

1 reference

5 June 2018

Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

negative regulation of epithelial cell proliferation involved in prostate gland development

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

positive regulation of cell population proliferation

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

positive regulation of cyclin-dependent protein serine/threonine kinase activity

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

negative regulation of epithelial cell proliferation

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

positive regulation of microtubule polymerization

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

inner ear development

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

cellular response to antibiotic

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

negative regulation of phosphorylation

1 reference

5 June 2018

Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

negative regulation of transcription, DNA-templated

1 reference

5 June 2018

CDK inhibitors selectively diminish cell cycle controlled activation of the histone H4 gene promoter by p220NPAT and HiNF-P

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cells

autophagic cell death

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

negative regulation of cell population proliferation

3 references

5 June 2018

Knockdown of protein tyrosine phosphatase SHP-1 inhibits G1/S progression in prostate cancer cells through the regulation of components of the cell-cycle machinery

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

5 June 2018

Nkx3.1 and p27(KIP1) cooperate in proliferation inhibition and apoptosis induction in human androgen-independent prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

negative regulation of mitotic cell cycle

1 reference

10 September 2018

Nkx3.1 and p27(KIP1) cooperate in proliferation inhibition and apoptosis induction in human androgen-independent prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

negative regulation of kinase activity

1 reference

10 September 2018

CDK inhibitors selectively diminish cell cycle controlled activation of the histone H4 gene promoter by p220NPAT and HiNF-P

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

positive regulation of cell cycle

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

negative regulation of vascular associated smooth muscle cell proliferation

1 reference

10 September 2018

Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

regulation of exit from mitosis

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

regulation of lens fiber cell differentiation

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

negative regulation of cyclin-dependent protein kinase activity

1 reference

10 September 2018

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

negative regulation of cell cycle

IMP

1 reference

10 September 2018

A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

G1/S transition of mitotic cell cycle

IMP

3 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

5 June 2018

Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

G1/S transition of mitotic cell cycle

4 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

negative regulation of cell population proliferation

4 references

10 September 2018

Knockdown of protein tyrosine phosphatase SHP-1 inhibits G1/S progression in prostate cancer cells through the regulation of components of the cell-cycle machinery

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Nkx3.1 and p27(KIP1) cooperate in proliferation inhibition and apoptosis induction in human androgen-independent prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

negative regulation of cell growth

2 references

10 September 2018

Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

negative regulation of phosphorylation

2 references

10 September 2018

Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

positive regulation of protein catabolic process

negative regulation of cyclin-dependent protein serine/threonine kinase activity

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46527&geneProductId=UniProtKB:P46527

negative regulation of transcription, DNA-templated