DOCK8 regulates fitness and function of regulatory T cells through modulation of IL-2 signaling. (Q49598463)

29 June 2018

title

DOCK8 regulates fitness and function of regulatory T cells through modulation of IL-2 signaling. (English)

1 reference

29 June 2018

author

Ahmet Eken

2

1 reference

http://europepmc.org/abstract/MED/28978795

21 February 2018

Shaun W Jackson

object named as

Shaun W Jackson

8

0 references

author name string

Akhilesh K Singh

1

1 reference

29 June 2018

David Hagin

3

1 reference

29 June 2018

Khushbu Komal

4

1 reference

29 June 2018

Gauri Bhise

5

1 reference

29 June 2018

Azima Shaji

6

1 reference

29 June 2018

Tanvi Arkatkar

7

1 reference

29 June 2018

Estelle Bettelli

9

1 reference

29 June 2018

Troy R Torgerson

10

1 reference

29 June 2018

Mohamed Oukka

11

1 reference

29 June 2018

publication date

5 October 2017

1 reference

29 June 2018

published in

JCI insight

1 reference

29 June 2018

volume

2

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29 June 2018

issue

19

1 reference

29 June 2018

LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis

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Immune homeostasis enforced by co-localized effector and regulatory T cells

30 June 2018

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IL-2Rα mediates temporal regulation of IL-2 signaling and enhances immunotherapy.

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DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity

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Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells

30 June 2018

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DOCK8 regulates protective immunity by controlling the function and survival of RORγt+ ILCs

30 June 2018

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DOCK8 is critical for the survival and function of NKT cells

30 June 2018

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Novel Foxo1-dependent transcriptional programs control T(reg) cell function

30 June 2018

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DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation

30 June 2018

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Additional diverse findings expand the clinical presentation of DOCK8 deficiency

30 June 2018

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DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses

30 June 2018

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30 June 2018

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Regulatory T cells: mechanisms of differentiation and function

30 June 2018

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DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice

30 June 2018

1 reference

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DOCK8 is essential for T-cell survival and the maintenance of CD8+ T-cell memory

30 June 2018

1 reference

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An essential role of the transcription factor GATA-3 for the function of regulatory T cells

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells

30 June 2018

1 reference

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DOCK8 immune deficiency as a model for primary cytoskeletal dysfunction.

30 June 2018

1 reference

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The essential role of DOCK8 in humoral immunity

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Foxo transcription factors control regulatory T cell development and function

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Dedicator of cytokinesis 8 (DOCK8) deficiency

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Combined immunodeficiency associated with DOCK8 mutations

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Regulatory T cells: how do they suppress immune responses?

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Regulatory T cells and immune tolerance

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces

30 June 2018

1 reference

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CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Thymic development and peripheral homeostasis of regulatory T cells.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Nonredundant roles for Stat5a/b in directly regulating Foxp3

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

A function for interleukin 2 in Foxp3-expressing regulatory T cells

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

An essential role for Scurfin in CD4+CD25+ T regulatory cells

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Control of regulatory T cell development by the transcription factor Foxp3

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Regulatory T cells in autoimmmunity*.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Possible mechanism for the alpha subunit of the interleukin-2 receptor (CD25) to influence interleukin-2 receptor signal transduction

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841873

Essential Role for STAT5 Signaling in CD25+CD4+ Regulatory T Cell Homeostasis and the Maintenance of Self-Tolerance

1 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28978795

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI.INSIGHT.94275

1 reference

29 June 2018

PMCID

5841873

1 reference

29 June 2018

PubMed ID

28978795

1 reference

29 June 2018