Correction of lung inflammation in a F508del CFTR murine cystic fibrosis model by the sphingosine-1-phosphate lyase inhibitor LX2931. (Q48678102)

14 February 2018

title

Correction of lung inflammation in a F508del CFTR murine cystic fibrosis model by the sphingosine-1-phosphate lyase inhibitor LX2931. (English)

1 reference

14 February 2018

0 references

0 references

3

1 reference

14 February 2018

Oleh Dzyubachyk

object named as

Oleh Dzyubachyk

7

0 references

Juan B De Sanctis

object named as

Juan B De Sanctis

5

0 references

author name string

Mieke Veltman

1

1 reference

14 February 2018

Marta Stolarczyk

2

1 reference

14 February 2018

Gabriella Wojewodka

4

1 reference

14 February 2018

Willem A Dik

6

1 reference

14 February 2018

Tamas Oravecz

8

1 reference

14 February 2018

Ismé de Kleer

9

1 reference

14 February 2018

Bob J Scholte

10

1 reference

14 February 2018

publication date

23 September 2016

1 reference

14 February 2018

American Journal of Physiology - Lung Cellular and Molecular Physiology

published in

1 reference

14 February 2018

volume

311

1 reference

14 February 2018

issue

5

1 reference

14 February 2018

page(s)

L1000-L1014

1 reference

14 February 2018

Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion

cites work

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Air trapping and airflow obstruction in newborn cystic fibrosis piglets

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Inhibition of sphingosine 1-phosphate lyase for the treatment of rheumatoid arthritis: discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone oxime (LX2931) and (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Newborn Cystic Fibrosis Pigs Have a Blunted Early Response to an Inflammatory Stimulus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Acid sphingomyelinase inhibitors normalize pulmonary ceramide and inflammation in cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Salivary secretion assay for drug efficacy for cystic fibrosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Comprehensive quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Sphingolipids as Regulators of the Phagocytic Response to Fungal Infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Proteomic analysis of naphthalene-induced airway epithelial injury and repair in a cystic fibrosis mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

The CFTR and ENaC debate: how important is ENaC in CF lung disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

In vivo models of lung neutrophil activation. Comparison of mice and hamsters

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

A functional CFTR assay using primary cystic fibrosis intestinal organoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Development and functional specialization of CD103+ dendritic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Critical role of cytosolic phospholipase A2{alpha} in bronchial mucus hypersecretion in CFTR-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Na+/H+ exchanger regulatory factor 1 overexpression-dependent increase of cytoskeleton organization is fundamental in the rescue of F508del cystic fibrosis transmembrane conductance regulator in human airway CFBE41o- cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

A delta F508 mutation in mouse cystic fibrosis transmembrane conductance regulator results in a temperature-sensitive processing defect in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Regulation of the inflammasome by ceramide in cystic fibrosis lungs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Ceramide in cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Cystic fibrosis fatty acid imbalance is linked to ceramide deficiency and corrected by fenretinide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Structural insights into PDZ-mediated interaction of NHERF2 and LPA2, a cellular event implicated in CFTR channel regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Sphingosine-1-phosphate lyase is an endogenous suppressor of pulmonary fibrosis: role of S1P signalling and autophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Dysregulated proinflammatory and fibrogenic phenotype of fibroblasts in cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Mature cystic fibrosis airway neutrophils suppress T cell function: evidence for a role of arginase 1 but not programmed death-ligand 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

IL-12-STAT4-IFN-gamma axis is a key downstream pathway in the development of IL-13-mediated asthma phenotypes in a Th2 type asthma model

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Lyase to live by: sphingosine phosphate lyase as a therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Sphingosine kinase and sphingosine 1-phosphate in asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Dendritic cell and epithelial cell interactions at the origin of murine asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Metabolic adaptation of neutrophils in cystic fibrosis airways involves distinct shifts in nutrient transporter expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Azithromycin reduces spontaneous and induced inflammation in DeltaF508 cystic fibrosis mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Targeting S1P1 receptor protects against murine immunological hepatic injury through myeloid-derived suppressor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Sphingosine-1-phosphate and its analogue FTY720 diminish acute pulmonary injury in rats with acute necrotizing pancreatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Bronchiectasis and pulmonary exacerbations in children and young adults with cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Targeting autophagy as a novel strategy for facilitating the therapeutic action of potentiators on ΔF508 cystic fibrosis transmembrane conductance regulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

S1P lyase in thymic perivascular spaces promotes egress of mature thymocytes via up-regulation of S1P receptor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Azithromycin reduces exaggerated cytokine production by M1 alveolar macrophages in cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

The B lymphocyte differentiation factor (BAFF) is expressed in the airways of children with CF and in lungs of mice infected with Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Expression of Intestinal and Lung Alkaline Sphingomyelinase and Neutral Ceramidase in Cystic Fibrosis F508del Transgenic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Role of IL-1β in experimental cystic fibrosis upon P. aeruginosa infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Tumor necrosis factor (TNF) receptor-associated factor (TRAF)-interacting protein (TRIP) negatively regulates the TRAF2 ubiquitin-dependent pathway by suppressing the TRAF2-sphingosine 1-phosphate (S1P) interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Infection, inflammation, and lung function decline in infants with cystic fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Monocyte-derived dendritic cells: targets as potent antigen-presenting cells for the design of vaccines against infectious diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Role of epithelial HCO3⁻ transport in mucin secretion: lessons from cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Extracellular matrix defects in aneurysmal Fibulin-4 mice predispose to lung emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Immunosuppressive MDSCs induced by TLR signaling during infection and role in resolution of inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Current concepts of immune dysregulation in cystic fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Correction of the Delta phe508 cystic fibrosis transmembrane conductance regulator trafficking defect by the bioavailable compound glafenine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

PRAGMA-CF. A Quantitative Structural Lung Disease Computed Tomography Outcome in Young Children with Cystic Fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation through the ZONAB pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

The role of the NHERF family of PDZ scaffolding proteins in the regulation of salt and water transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Early intervention studies in infants and preschool children with cystic fibrosis: are we ready?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

New concepts of IL-10-induced lung fibrosis: fibrocyte recruitment and M2 activation in a CCL2/CCR2 axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Sphingosine 1-phosphate rescues canine LPS-induced acute lung injury and alters systemic inflammatory cytokine production in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Lack of Sphingosine Causes Susceptibility to Pulmonary Staphylococcus Aureus Infections in Cystic Fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

A Th17- and Th2-skewed cytokine profile in cystic fibrosis lungs represents a potential risk factor for Pseudomonas aeruginosa infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Genetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Considerations for the Conduct of Clinical Trials with Antiinflammatory Agents in Cystic Fibrosis. A Cystic Fibrosis Foundation Workshop Report

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Sphingolipids in the lungs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Novel insights related to CF neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

The β-human chorionic gonadotropin-related peptide LQGV reduces mortality and inflammation in a murine polymicrobial sepsis model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Rescue of murine F508del CFTR activity in native intestine by low temperature and proteasome inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Mouse models of cystic fibrosis: phenotypic analysis and research applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Ceramide in cystic fibrosis: a potential new target for therapeutic intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Lipid metabolism in cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Low sphingosine-1-phosphate impairs lung dendritic cells in cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

10.1152/AJPLUNG.00298.2016

21 January 2018

Identifiers

DOI

1 reference

14 February 2018

PubMed ID

27663991

1 reference

14 February 2018