Ceramide in cystic fibrosis: a potential new target for therapeutic intervention (Q42005356)

15 October 2017

1 reference

title

Ceramide in cystic fibrosis: a potential new target for therapeutic intervention (English)

1 reference

15 October 2017

0 references

1 reference

3

Danuta Radzioch

1 reference

15 October 2017

Gabriella Wojewodka

1

1 reference

PMCID

3066841

15 October 2017

Juan B De Sanctis

series ordinal

2

1 reference

15 October 2017

28 December 2010

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15 October 2017

1 reference

15 October 2017

2011

1 reference

15 October 2017

674968

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Creative Commons Attribution 3.0 Unported

15 October 2017

start time

1 January 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

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Revisiting the role of cystic fibrosis transmembrane conductance regulator and counterion permeability in the pH regulation of endocytic organelles

5 June 2018

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5 June 2018

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Ceramide-dependent PP2A regulation of TNFalpha-induced IL-8 production in respiratory epithelial cells.

5 June 2018

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5 June 2018

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Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid

5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis

5 June 2018

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5 June 2018

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5 June 2018

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Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance

5 June 2018

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Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis

5 June 2018

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5 June 2018

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Fenretinide corrects newly found ceramide deficiency in cystic fibrosis

5 June 2018

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Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction

5 June 2018

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5 June 2018

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Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy

5 June 2018

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5 June 2018

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5 June 2018

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Mechanisms of fenretinide-induced apoptosis

5 June 2018

1 reference

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Apoptosis induced by intracellular ceramide accumulation in MDA-MB-435 breast carcinoma cells is dependent on the generation of reactive oxygen species

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha

5 June 2018

1 reference

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Sphingolipidomics: high-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry

5 June 2018

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Fenretinide stimulates redox-sensitive ceramide production in breast cancer cells: potential role in drug-induced cytotoxicity

5 June 2018

1 reference

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Characteristic multiorgan pathology of cystic fibrosis in a long-living cystic fibrosis transmembrane regulator knockout murine model

5 June 2018

1 reference

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Localization of cystic fibrosis transmembrane conductance regulator to lipid rafts of epithelial cells is required for Pseudomonas aeruginosa-induced cellular activation

5 June 2018

1 reference

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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

5 June 2018

1 reference

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A simple method for the isolation and purification of total lipides from animal tissues

5 June 2018

1 reference

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Pseudomonas aeruginosa-induced apoptosis is defective in respiratory epithelial cells expressing mutant cystic fibrosis transmembrane conductance regulator.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Hyperacidification in cystic fibrosis: links with lung disease and new prospects for treatment

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Separation, identification and quantitation of ceramides in human cancer cells by liquid chromatography-electrospray ionization tandem mass spectrometry.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Non-CFTR chloride channels likely contribute to secretion in the murine small intestine

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Determination of ceramides and diglycerides by the diglyceride kinase assay

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Ceramide-mediated apoptosis in lung epithelial cells is regulated by glutathione

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

N-(4-hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Lipid rafts and signal transduction

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Current methods for the identification and quantitation of ceramides: an overview

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

A membrane lipid imbalance plays a role in the phenotypic expression of cystic fibrosis in cftr(-/-) mice

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Increase of ceramide and induction of mixed apoptosis/necrosis by N-(4-hydroxyphenyl)- retinamide in neuroblastoma cell lines

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Signal transduction of stress via ceramide

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Lef1 transcription factor expression defines airway progenitor cell targets for in utero gene therapy of submucosal gland in cystic fibrosis

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Lung disease in mice with cystic fibrosis

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Fas-induced apoptosis of T cells occurs independently of ceramide generation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype-phenotype correlations.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Ceramide activates heterotrimeric protein phosphatase 2A.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Toward an animal model of cystic fibrosis: targeted interruption of exon 10 of the cystic fibrosis transmembrane regulator gene in embryonic stem cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Fatty acid supplementation in cystic fibrosis

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Alterations in ceramide concentration and pH determine the release of reactive oxygen species by Cftr-deficient macrophages on infection

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Comprehensive quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Potential mechanisms involved in ceramide-induced apoptosis in human colon cancer HT29 cells.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Cystic fibrosis fatty acid imbalance is linked to ceramide deficiency and corrected by fenretinide.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Fenretinide prevents the development of osteoporosis in Cftr-KO mice.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Ceramide inhibits LPS-induced production of IL-5, IL-10, and IL-13 from mast cells.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

No indications for altered essential fatty acid metabolism in two murine models for cystic fibrosis

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Ceramide signaling in fenretinide-induced endothelial cell apoptosis

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

The severe G480C cystic fibrosis mutation, when replicated in the mouse, demonstrates mistrafficking, normal survival and organ-specific bioelectrics.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Mouse anti-ceramide antiserum: a specific tool for the detection of endogenous ceramide

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Production of a severe cystic fibrosis mutation in mice by gene targeting

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Dietary changes improve survival of CFTR S489X homozygous mutant mouse.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3066841

Expression of Intestinal and Lung Alkaline Sphingomyelinase and Neutral Ceramidase in Cystic Fibrosis F508del Transgenic Mice

17 August 2018

1 reference

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Distinct pattern of lung gene expression in the Cftr-KO mice developing spontaneous lung disease compared with their littermate controls

21 January 2018

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https://api.crossref.org/works/10.1155%2F2011%2F674968

Interleukin-8 Concentrations Are Elevated in Bronchoalveolar Lavage, Sputum, and Sera of Children with Cystic Fibrosis

21 January 2018

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Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry

21 January 2018

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12 December 2020

Ceramide profiling of complex lipid mixtures by electrospray ionization mass spectrometry

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12 December 2020

Lysosomal alterations induced in cultured rat fibroblasts by long-term exposure to low concentrations of azithromycin

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12 December 2020

Structural determinants of sphingolipid recognition by commercially available anti-ceramide antibodies

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12 December 2020

Programmed cell death induced by ceramide

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12 December 2020

Ceramide second messengers and ceramide assays

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12 December 2020

Ceramide is increased in the lower airway epithelium of people with advanced cystic fibrosis lung disease

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12 December 2020

Early inflammation in the airways of a cystic fibrosis foetus

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12 December 2020

4-HPR-mediated leukemia cell cytotoxicity is triggered by ceramide-induced mitochondrial oxidative stress and is regulated downstream by Bcl-2

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12 December 2020

Plasma lipids are altered in Gaucher disease: biochemical markers to evaluate therapeutic intervention

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12 December 2020

Nasal and bronchoalveolar lavage fluid cytokines in early cystic fibrosis

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12 December 2020

Early pulmonary inflammation in infants with cystic fibrosis

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12 December 2020

The use of diglyceride kinase for quantifying ceramide

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12 December 2020

Ceramides of pig epidermis: structure determination

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12 December 2020

Identifiers

DOI

10.1155/2011/674968

1 reference

15 October 2017

1 reference

15 October 2017

1 reference

PMCID

3066841