Ontogenic reduction of Aph-1b mRNA and gamma-secretase activity in rats with a complex neurodevelopmental phenotype. (Q48527061)

12 February 2018

title

Ontogenic reduction of Aph-1b mRNA and gamma-secretase activity in rats with a complex neurodevelopmental phenotype. (English)

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12 February 2018

author

Marcel W Coolen

1

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12 February 2018

author name string

van Loo KM

2

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12 February 2018

Ellenbroek BA

3

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12 February 2018

Cools AR

4

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12 February 2018

Martens GJ

5

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12 February 2018

language of work or name

English

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publication date

23 May 2006

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12 February 2018

published in

Molecular Psychiatry

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12 February 2018

volume

11

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12 February 2018

issue

8

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12 February 2018

page(s)

787-793

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12 February 2018

https://scigraph.springernature.com/pub.10.1038/sj.mp.4001846

exact match

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cites work

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Gene dosage effect on gamma-secretase component Aph-1b in a rat model for neurodevelopmental disorders

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Gamma-secretase: proteasome of the membrane?

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Identity and function of γ‐secretase

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gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

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Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

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Identification of distinct gamma-secretase complexes with different APH-1 variants

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Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals

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APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

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Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

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Reduced Aph-1b expression causes tissue- and substrate-specific changes in gamma-secretase activity in rats with a complex phenotype

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Normal brain development in PS1 hypomorphic mice with markedly reduced gamma-secretase cleavage of betaAPP.

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APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development

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Spatial learning deficit in mice expressing human 751-amino acid beta-amyloid precursor protein.

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Transgenic mice expressing the human C99 terminal fragment of betaAPP: effects on spatial learning, exploration, anxiety, and motor coordination.

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Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

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7 January 2021

Identifiers

DOI

10.1038/SJ.MP.4001846

1 reference

12 February 2018

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12 February 2018