Why Have Clinical Trials of Antioxidants to Prevent Neurodegeneration Failed? - A Cellular Investigation of Novel Phenothiazine-Type Antioxidants Reveals Competing Objectives for Pharmaceutical Neuroprotection. (Q48413563)

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scientific article published on 28 November 2016

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English	Why Have Clinical Trials of Antioxidants to Prevent Neurodegeneration Failed? - A Cellular Investigation of Novel Phenothiazine-Type Antioxidants Reveals Competing Objectives for Pharmaceutical Neuroprotection.	scientific article published on 28 November 2016

Statements

scholarly article

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27896592

Why Have Clinical Trials of Antioxidants to Prevent Neurodegeneration Failed? - A Cellular Investigation of Novel Phenothiazine-Type Antioxidants Reveals Competing Objectives for Pharmaceutical Neuroprotection. (English)

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Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27896592

neurodegeneration

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based on heuristic

inferred from title

author name string

Maike J Ohlow

1

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Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27896592

Selina Sohre

2

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Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27896592

Matthias Granold

3

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27896592

Mathias Schreckenberger

4

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27896592

Bernd Moosmann

5

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27896592

publication date

28 November 2016

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Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27896592

Pharmaceutical Research

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Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27896592

34

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Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27896592

2

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Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27896592

378-393

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11 February 2018

http://europepmc.org/abstract/MED/27896592

Oxidative stress and neurodegeneration: where are we now?

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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1,026 experimental treatments in acute stroke

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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Free radical trapping as a therapeutic approach to neuroprotection in stroke: experimental and clinical studies with NXY-059 and free radical scavengers

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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Free radical scavenger, edaravone, in stroke with internal carotid artery occlusion

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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Oxidative damage in ischemic stroke revealed using multiple biomarkers.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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High membrane protein oxidation in the human cerebral cortex

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

21 January 2018

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1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

21 January 2018

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1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

21 January 2018

Nitrones as therapeutics

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

21 January 2018

Oxidative nerve cell death in Alzheimer's disease and stroke: antioxidants as neuroprotective compounds

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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Vitamin E and donepezil for the treatment of mild cognitive impairment

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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Idebenone treatment fails to slow cognitive decline in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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Alpha tocopherol in CSF of subjects taking high-dose vitamin E in the DATATOP study. Parkinson Study Group.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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Mice lacking alpha-tocopherol transfer protein gene have severe alpha-tocopherol deficiency in multiple regions of the central nervous system

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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Regulation of ubiquinone metabolism

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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Novel imine antioxidants at low nanomolar concentrations protect dopaminergic cells from oxidative neurotoxicity

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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Protective activity of aromatic amines and imines against oxidative nerve cell death

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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Antioxidant activity applying an improved ABTS radical cation decolorization assay

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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Quantitative structure-activity relationship analysis of phenolic antioxidants

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

21 January 2018

The regulation of reactive oxygen species production during programmed cell death

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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Phenothiazine: the seven lives of pharmacology's first lead structure

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

21 January 2018

Recent advances in the biochemistry and clinical relevance of the isoprostane pathway

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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Hypoxia-mediated degradation of Na,K-ATPase via mitochondrial reactive oxygen species and the ubiquitin-conjugating system.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

21 January 2018

Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

21 January 2018

Phenothiazines interfere with dopaminergic neurodegeneration in Caenorhabditis elegans models of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

21 January 2018

On the anti-atherogenic effect of the antioxidant BHT in cholesterol-fed rabbits: inverse relation between serum triglycerides and atheromatous lesions

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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Can molecular and cellular neuroprotection be translated into therapies for patients?: yes, but not the way we tried it before

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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Instability of, and generation of hydrogen peroxide by, phenolic compounds in cell culture media

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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1 reference

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1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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A phenothiazine derivative reduces rat brain damage after global or focal ischemia

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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The antioxidative, non-psychoactive tricyclic phenothiazine reduces brain damage after experimental traumatic brain injury in mice.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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1 reference

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1 reference

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1 reference

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1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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Membrane protein oxidation determines neuronal degeneration

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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Brain protein oxidation: what does it reflect?

1 reference

https://api.crossref.org/works/10.1007%2FS11095-016-2068-0

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1 reference

https://pubmed.ncbi.nlm.nih.gov/27896592

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based on heuristic

inferred from PubMed ID database lookup

Final report on the safety assessment of BHT(1).

1 reference

https://pubmed.ncbi.nlm.nih.gov/27896592

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NXY-059 for the treatment of acute ischemic stroke

1 reference

https://pubmed.ncbi.nlm.nih.gov/27896592

12 December 2020

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inferred from PubMed ID database lookup

Is the chromanol head group of vitamin E nature's final truth on chain-breaking antioxidants?

1 reference

https://pubmed.ncbi.nlm.nih.gov/27896592

12 December 2020

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inferred from PubMed ID database lookup

The prevention of cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/27896592

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based on heuristic

inferred from PubMed ID database lookup

Do spin traps also act as classical chain-breaking antioxidants? A quantitative kinetic study of phenyl tert-butylnitrone (PBN) in solution and in liposomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27896592

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inferred from PubMed ID database lookup

Human studies related to protein oxidation: protein carbonyl content as a marker of damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/27896592

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based on heuristic

inferred from PubMed ID database lookup

Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/27896592

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inferred from PubMed ID database lookup

Oxidative glutamate toxicity can be a component of the excitotoxicity cascade.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27896592

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is the door open again for neuroprotection trials in stroke?

1 reference

https://pubmed.ncbi.nlm.nih.gov/27896592

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/27896592

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11095-016-2068-0

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27896592

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27896592

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