Electrophiles in foods: the current status of isothiocyanates and their chemical biology (Q37688791)

22 August 2017

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title

Electrophiles in foods: the current status of isothiocyanates and their chemical biology (English)

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22 August 2017

Yoshimasa Nakamura

1

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PubMed ID

20139631

22 August 2017

Noriyuki Miyoshi

series ordinal

2

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22 August 2017

7 February 2010

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Bioscience, Biotechnology, and Biochemistry

22 August 2017

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22 August 2017

74

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22 August 2017

2

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22 August 2017

242-255

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ER stress and the unfolded protein response

22 August 2017

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Hypoxia-induced and stress-specific changes in chromatin structure and function

21 January 2018

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Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids

21 January 2018

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Lipid peroxidation and redox-sensitive signaling pathways

21 January 2018

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Phospholipid hydroperoxide glutathione peroxidase activity of human glutathione transferases

21 January 2018

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Transcriptional regulation via cysteine thiol modification: a novel molecular strategy for chemoprevention and cytoprotection

21 January 2018

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Rapid detection of inducers of enzymes that protect against carcinogens

21 January 2018

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Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis

21 January 2018

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A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure

21 January 2018

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A glutathione S-transferase inducer from papaya: rapid screening, identification and structure-activity relationship of isothiocyanates

21 January 2018

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Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis

21 January 2018

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Pivotal role of electrophilicity in glutathione S-transferase induction by tert-butylhydroquinone

21 January 2018

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A phase II detoxification enzyme inducer from lemongrass: identification of citral and involvement of electrophilic reaction in the enzyme induction

21 January 2018

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Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes

21 January 2018

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A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway

21 January 2018

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The potency of inducers of NAD(P)H:(quinone-acceptor) oxidoreductase parallels their efficiency as substrates for glutathione transferases. Structural and electronic correlations

21 January 2018

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(-)-Epigallocatechin-3-gallate potentiates the cytotoxicity induced by benzyl isothiocyanate and hydrogen peroxide in human Jurkat T lymphocytes

21 January 2018

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(-)-Epigallocatechin-3-gallate induces up-regulation of Th1 and Th2 cytokine genes in Jurkat T cells

21 January 2018

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Nitric oxide-induced mitochondrial dysfunction: implications for neurodegeneration

21 January 2018

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Flavonoid-serum albumin complexation: determination of binding constants and binding sites by fluorescence spectroscopy

21 January 2018

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Albumin stabilizes (-)-epigallocatechin gallate in human serum: binding capacity and antioxidant property

21 January 2018

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Bioavailability of [2-(14)C]quercetin-4'-glucoside in rats

21 January 2018

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Catechol type polyphenol is a potential modifier of protein sulfhydryls: development and application of a new probe for understanding the dietary polyphenol actions

21 January 2018

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Identification of zerumbone in Zingiber zerumbet Smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation

21 January 2018

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Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice

21 January 2018

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Chemoprevention of azoxymethane-induced rat aberrant crypt foci by dietary zerumbone isolated from Zingiber zerumbet

21 January 2018

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Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion

21 January 2018

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In vitro covalent binding proteins of zerumbone, a chemopreventive food factor

21 January 2018

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Inhibitory effects of curcumin and tetrahydrocurcuminoids on the tumor promoter-induced reactive oxygen species generation in leukocytes in vitro and in vivo.

21 January 2018

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Inhibition of nuclear factor kappaB by direct modification in whole cells--mechanism of action of nordihydroguaiaritic acid, curcumin and thiol modifiers.

21 January 2018

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Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity

21 January 2018

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Caffeic acid phenethyl ester and curcumin: a novel class of heme oxygenase-1 inducers

21 January 2018

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Sites of alkylation of human Keap1 by natural chemoprevention agents

21 January 2018

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Structure-activity relationships of (1'S)-1'-acetoxychavicol acetate, a major constituent of a southeast Asian condiment plant Languas galanga, on the inhibition of tumor-promoter-induced Epstein-Barr virus activation

21 January 2018

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The chemical diversity and distribution of glucosinolates and isothiocyanates among plants

21 January 2018

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Inhibition of carcinogenesis by isothiocyanates

21 January 2018

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Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans

21 January 2018

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Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China.

21 January 2018

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Isothiocyanates as substrates for human glutathione transferases: structure-activity studies.

21 January 2018

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Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action.

21 January 2018

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Benzyl isothiocyanate inhibits excessive superoxide generation in inflammatory leukocytes: implication for prevention against inflammation-related carcinogenesis

21 January 2018

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Dietary isothiocyanates modify mitochondrial functions through their electrophilic reaction

21 January 2018

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The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells

21 January 2018

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Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosis

21 January 2018

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Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron

21 January 2018

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Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism

21 January 2018

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Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response

21 January 2018

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Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity

21 January 2018

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The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds

21 January 2018

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Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation

21 January 2018

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Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase

21 January 2018

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Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes

21 January 2018

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TRP channel activation by reversible covalent modification

21 January 2018

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Glutathione- and cysteine-mediated cytotoxicity of allyl and benzyl isothiocyanate.

21 January 2018

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Covalent modification of lysine residues by allyl isothiocyanate in physiological conditions: plausible transformation of isothiocyanate from thiol to amine.

21 January 2018

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Involvement of the mitochondrial death pathway in chemopreventive benzyl isothiocyanate-induced apoptosis

21 January 2018

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A link between benzyl isothiocyanate-induced cell cycle arrest and apoptosis: involvement of mitogen-activated protein kinases in the Bcl-2 phosphorylation

21 January 2018

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Selective cytotoxicity of benzyl isothiocyanate in the proliferating fibroblastoid cells

21 January 2018

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Papaya seed represents a rich source of biologically active isothiocyanate

21 January 2018

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ATP depletion alters the mode of cell death induced by benzyl isothiocyanate.

21 January 2018

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Induction of apoptosis in tumor cells by naturally occurring sulfur-containing compounds

21 January 2018

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Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C.

21 January 2018

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Strong promoting activity of phenylethyl isothiocyanate and benzyl isothiocyanate on urinary bladder carcinogenesis in F344 male rats

21 January 2018

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Involvement of toxicity as an early event in urinary bladder carcinogenesis induced by phenethyl isothiocyanate, benzyl isothiocyanate, and analogues in F344 rats

21 January 2018

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Toxic dose of a simple phenolic antioxidant, protocatechuic acid, attenuates the glutathione level in ICR mouse liver and kidney

21 January 2018

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21 January 2018

Identifiers

DOI

10.1271/BBB.90731

1 reference

22 August 2017

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PubMed ID

20139631