PARP expression is increased in astrocytes but decreased in motor neurons in the spinal cord of sporadic ALS patients. (Q48409115)

11 February 2018

title

PARP expression is increased in astrocytes but decreased in motor neurons in the spinal cord of sporadic ALS patients. (English)

1 reference

11 February 2018

amyotrophic lateral sclerosis

main subject

astrocyte

0 references

1 reference

9

Stanley H Appel

1 reference

11 February 2018

author name string

Seung H Kim

1

1 reference

11 February 2018

Jenny S Henkel

2

1 reference

11 February 2018

David R Beers

3

1 reference

11 February 2018

Ihsan S Sengun

4

1 reference

11 February 2018

Ericka P Simpson

5

1 reference

11 February 2018

J Clay Goodman

6

1 reference

11 February 2018

Jozsef I Engelhardt

7

1 reference

11 February 2018

László Siklós

8

1 reference

11 February 2018

publication date

1 January 2003

1 reference

11 February 2018

Journal of Neuropathology & Experimental Neurology

published in

1 reference

11 February 2018

volume

62

1 reference

11 February 2018

issue

1

1 reference

11 February 2018

page(s)

88-103

1 reference

11 February 2018

Remarkable increase in cerebrospinal fluid 3-nitrotyrosine in patients with sporadic amyotrophic lateral sclerosis

cites work

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Presence of 4-hydroxynonenal in cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Colocalization of NOS and SOD1 in neurofilament accumulation within motor neurons of amyotrophic lateral sclerosis: an immunohistochemical study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

A receptor for advanced glycosylation endproducts (AGEs) is colocalized with neurofilament-bound AGEs and SOD1 in motoneurons of ALS: immunohistochemical study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Inducible nitric oxide synthase (iNOS) and nitrotyrosine immunoreactivity in the spinal cords of transgenic mice with a G93A mutant SOD1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Reduction of acute photodamage in skin by topical application of a novel PARP inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Prevention of oxidant-induced cell death in Caco-2 colon carcinoma cells after inhibition of poly(ADP-ribose) polymerase and Ca2+ chelation: involvement of a common mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

A fast signal-induced activation of Poly(ADP-ribose) polymerase: a novel downstream target of phospholipase c.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Nitric oxide toxicity in CNS white matter: an in vitro study using rat optic nerve

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Role of poly(ADP-ribose) formation in DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Decreases in mouse brain NAD+ and ATP induced by 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP): prevention by the poly(ADP-ribose) polymerase inhibitor, benzamide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Role of peroxynitrite and neuronal nitric oxide synthase in the activation of poly(ADP-ribose) synthetase in a murine model of cerebral ischemia-reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Neuronal accumulation of poly(ADP-ribose) after brain ischaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Apoptosis and expression of DNA repair proteins in ischaemic brain injury in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

DNA damage and activated caspase-3 expression in neurons and astrocytes: evidence for apoptosis in frontotemporal dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Poly(ADP-ribose) polymerase localizes to the centrosomes and chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

PARP co-activates B-MYB through enhanced phosphorylation at cyclin/cdk2 sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Overexpression of poly(ADP-ribose) polymerase disrupts organization of cytoskeletal F-actin and tissue polarity in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Role of SOD-1 and nitric oxide/cyclic GMP cascade on neurofilament aggregation in ALS/MND.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Amyotrophic lateral sclerosis associated with genetic abnormalities in the gene encoding Cu/Zn superoxide dismutase: molecular pathology of five new cases, and comparison with previous reports and 73 sporadic cases of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

High molecular weight complexes of mutant superoxide dismutase 1: age-dependent and tissue-specific accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors: a molecular determinant of selective vulnerability in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Effects of an inhibitor of poly(ADP-ribose) polymerase, desmethylselegiline, trientine, and lipoic acid in transgenic ALS mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Poly(ADP-ribose) polymerase: a molecular nick-sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Peroxynitrite inhibits glutamate transporter subtypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Na+ dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) in primary astrocyte cultures: effect of oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

The poly(ADP-ribose) glycohydrolase inhibitor gallotannin blocks oxidative astrocyte death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Trophic support of motoneurons: physiological, pathophysiological, and therapeutic implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Intense superoxide dismutase-1 immunoreactivity in intracytoplasmic hyaline inclusions of familial amyotrophic lateral sclerosis with posterior column involvement.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Neuroprotection by metabotropic glutamate receptor agonists on kainate-induced degeneration of motor neurons in spinal cord slices from adult rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Adult rat brain astrocytes support survival of both NGF-dependent and NGF-insensitive neurones

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

21 January 2018

Identifiers

DOI

10.1093/JNEN/62.1.88

1 reference

11 February 2018

1 reference

11 February 2018