Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. (Q48616927)

13 February 2018

title

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. (English)

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13 February 2018

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Eliasson MJ

1

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13 February 2018

Sampei K

2

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13 February 2018

Mandir AS

3

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13 February 2018

Hurn PD

4

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13 February 2018

Traystman RJ

5

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13 February 2018

Bao J

6

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13 February 2018

Pieper A

7

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13 February 2018

Wang ZQ

8

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13 February 2018

Dawson TM

9

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13 February 2018

Snyder SH

10

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13 February 2018

Dawson VL

11

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13 February 2018

language of work or name

English

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publication date

1 October 1997

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13 February 2018

published in

Nature Medicine

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13 February 2018

volume

3

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13 February 2018

page(s)

1089-1095

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13 February 2018

issue

10

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13 February 2018

https://scigraph.springernature.com/pub.10.1038/nm1097-1089

exact match

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cites work

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Pathological implications of nitric oxide, superoxide and peroxynitrite formation

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Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia

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Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice

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Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells.

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Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle

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Excitotoxicity in the lung: N-methyl-D-aspartate-induced, nitric oxide-dependent, pulmonary edema is attenuated by vasoactive intestinal peptide and by inhibitors of poly(ADP-ribose) polymerase

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DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite

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Peroxynitrite causes energy depletion and increases permeability via activation of poly (ADP-ribose) synthetase in pulmonary epithelial cells

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Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase.

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Antagonism of non-NMDA receptors augments the neuroprotective effect of NMDA receptor blockade in cortical cultures subjected to prolonged deprivation of oxygen and glucose

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Oxygen or glucose deprivation-induced neuronal injury in cortical cell cultures is reduced by tetanus toxin

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Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats.

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Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia

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Molecular and biochemical features of poly (ADP-ribose) metabolism

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Structure and function of poly(ADP-ribose) polymerase

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Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase

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Nitric oxide toxicity in islet cells involves poly(ADP-ribose) polymerase activation and concomitant NAD+ depletion.

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Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity

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Poly(ADP-ribose) synthetase activation: an early indicator of neurotoxic DNA damage

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7 January 2021

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease

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7 January 2021

Inhibitors and activators of ADP-ribosylation reactions

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PARP is important for genomic stability but dispensable in apoptosis

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Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase

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7 January 2021

Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase.

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7 January 2021

Roles for oxidative stress and poly(ADP-ribosyl)ation in the killing of cultured hepatocytes by methyl methanesulfonate

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7 January 2021

Reactive oxygen injury to cultured pulmonary artery endothelial cells: mediation by poly(ADP-ribose) polymerase activation causing NAD depletion and altered energy balance

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7 January 2021

Lipid peroxidation, protein thiol oxidation and DNA damage in hydrogen peroxide-induced injury to endothelial cells: role of activation of poly(ADP-ribose)polymerase

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7 January 2021

Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues

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7 January 2021

Detection of poly(ADP-ribose) polymerase and its reaction product poly(ADP-ribose) by immunocytochemistry

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7 January 2021

Identifiers

DOI

10.1038/NM1097-1089

1 reference

13 February 2018

PubMed ID

9334719

1 reference

13 February 2018