Neurotoxic and gliotrophic activity of a synthetic peptide homologous to Gerstmann-Sträussler-Scheinker disease amyloid protein. (Q48272533)

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25 December 2019

title

Neurotoxic and gliotrophic activity of a synthetic peptide homologous to Gerstmann-Sträussler-Scheinker disease amyloid protein (English)

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7

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Claudia Manzoni

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Fabrizio Tagliavini

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Mario Salmona

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Roberto Chiesa

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25 December 2019

author name string

Luana Fioriti

1

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Nadia Angeretti

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Laura Colombo

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Ada De Luigi

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Alessio Colombo

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Gianluigi Forloni

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language of work or name

English

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publication date

1 February 2007

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25 December 2019

published in

Journal of Neuroscience

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volume

27

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issue

7

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page(s)

1576-1583

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Prion protein of 106 residues creates an artifical transmission barrier for prion replication in transgenic mice

25 December 2019

cites work

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Microglial cells respond to amyloidogenic PrP peptide by the production of inflammatory cytokines.

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Influence of mutations associated with familial prion-related encephalopathies on biological activity of prion protein peptides.

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The hydrophobic core sequence modulates the neurotoxic and secondary structure properties of the prion peptide 106-126.

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Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

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Intracellular mechanisms mediating the neuronal death and astrogliosis induced by the prion protein fragment 106-126.

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A model for the mechanism of astrogliosis in prion disease

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A nonfibrillar form of the fusogenic prion protein fragment [118-135] induces apoptotic cell death in rat cortical neurons.

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The role of prion peptide structure and aggregation in toxicity and membrane binding.

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12 December 2020

A 7-kDa prion protein (PrP) fragment, an integral component of the PrP region required for infectivity, is the major amyloid protein in Gerstmann-Sträussler-Scheinker disease A117V.

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12 December 2020

In vivo and in vitro neurotoxicity of the human prion protein (PrP) fragment P118-135 independently of PrP expression.

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12 December 2020

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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12 December 2020

Channels formed with a mutant prion protein PrP(82-146) homologous to a 7-kDa fragment in diseased brain of GSS patients.

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12 December 2020

Structural properties of Gerstmann-Straussler-Scheinker disease amyloid protein.

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12 December 2020

Prion protein preamyloid and amyloid deposits in Gerstmann-Sträussler-Scheinker disease, Indiana kindred

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12 December 2020

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

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12 December 2020

Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.

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12 December 2020

Squalestatin cures prion-infected neurons and protects against prion neurotoxicity.

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12 December 2020

Prion protein fragment 106-126 induces a p38 MAP kinase-dependent apoptosis in SH-SY5Y neuroblastoma cells independently from the amyloid fibril formation.

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12 December 2020

The neurotoxicity of prion protein (PrP) peptide 106-126 is independent of the expression level of PrP and is not mediated by abnormal PrP species.

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12 December 2020

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

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12 December 2020

Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers

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12 December 2020

Amidation and structure relaxation abolish the neurotoxicity of the prion peptide PrP106-126 in vivo and in vitro

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12 December 2020

Immunodetection of disease-associated mutant PrP, which accelerates disease in GSS transgenic mice

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12 December 2020

Gerstmann-Sträussler-Scheinker disease amyloid protein polymerizes according to the "dock-and-lock" model

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12 December 2020

Prostaglandin D2 mediates neuronal damage by amyloid-beta or prions which activates microglial cells.

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12 December 2020

Altered expression of the prion gene in rat astrocyte and neuron cultures treated with prion peptide 106-126

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12 December 2020

Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.

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12 December 2020

Amyloid Fibrils of Mammalian Prion Protein Are Highly Toxic to Cultured Cells and Primary Neurons

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12 December 2020

Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function.

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12 December 2020

Amyloid protein of Gerstmann-Sträussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58

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12 December 2020

Molecular biology of prion diseases

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12 December 2020

Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy

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12 December 2020

Mouse cortical cells lacking cellular PrP survive in culture with a neurotoxic PrP fragment

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12 December 2020

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins

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12 December 2020

Amyloid fibrils in Gerstmann-Sträussler-Scheinker disease (Indiana and Swedish kindreds) express only PrP peptides encoded by the mutant allele

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12 December 2020

A neurotoxic prion protein fragment induces rat astroglial proliferation and hypertrophy.

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12 December 2020

Mice devoid of PrP are resistant to scrapie

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12 December 2020

Conformational transitions, dissociation, and unfolding of scrapie amyloid (prion) protein

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12 December 2020

Neurotoxicity of a prion protein fragment.

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12 December 2020

Normal host prion protein necessary for scrapie-induced neurotoxicity.

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12 December 2020

Vascular variant of prion protein cerebral amyloidosis with tau-positive neurofibrillary tangles: the phenotype of the stop codon 145 mutation in PRNP.

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12 December 2020

A new variant of Creutzfeldt-Jakob disease in the UK.

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12 December 2020

Apoptosis-mediated neurotoxicity induced by beta-amyloid and PrP fragments.

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12 December 2020

Amyloid in Alzheimer's disease and prion-related encephalopathies: studies with synthetic peptides

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12 December 2020

Intracellular calcium rise through L-type calcium channels, as molecular mechanism for prion protein fragment 106-126-induced astroglial proliferation.

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12 December 2020

Proteinase-K-resistant prion protein isoforms in Gerstmann-Sträussler-Scheinker disease (Indiana kindred).

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12 December 2020

Recombinant scrapie-like prion protein of 106 amino acids is soluble

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12 December 2020

Prion protein fragment 106-126 differentially induces heme oxygenase-1 mRNA in cultured neurons and astroglial cells

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12 December 2020

Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent

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12 December 2020

Amidation of beta-amyloid peptide strongly reduced the amyloidogenic activity without alteration of the neurotoxicity.

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12 December 2020

Densitometric quantification of neuronal viability by computerized image analysis

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12 December 2020

Different patterns of truncated prion protein fragments correlate with distinct phenotypes in P102L Gerstmann-Sträussler-Scheinker disease

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12 December 2020

A prion protein fragment primes type 1 astrocytes to proliferation signals from microglia.

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12 December 2020

Phenotypic variability of Gerstmann-Sträussler-Scheinker disease is associated with prion protein heterogeneity.

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12 December 2020

Neurological illness in transgenic mice expressing a prion protein with an insertional mutation.

1 reference

12 December 2020

10.1523/JNEUROSCI.5145-06.2007

Identifiers

DOI

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