Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats. (Q48243268)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25849133%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

title

Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats (English)

1 reference

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4 March 2020

1 reference

6

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4 March 2020

Clémence D Côté

2

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4 March 2020

Guy A. Rutter

5

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4 March 2020

author name string

Frank A Duca

1

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4 March 2020

Brittany A Rasmussen

3

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4 March 2020

Melika Zadeh-Tahmasebi

4

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4 March 2020

Tony K T Lam

7

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4 March 2020

language of work or name

English

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publication date

6 April 2015

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4 March 2020

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4 March 2020

volume

21

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4 March 2020

issue

5

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4 March 2020

page(s)

506-511

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Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

4 March 2020

cites work

1 reference

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AMPK in the small intestine in normal and pathophysiological conditions.

8 September 2018

1 reference

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Jejunal leptin-PI3K signaling lowers glucose production.

8 September 2018

1 reference

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Identification and characterization of GLP-1 receptor-expressing cells using a new transgenic mouse model

8 September 2018

1 reference

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AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity

8 September 2018

1 reference

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Effects of sitagliptin and metformin treatment on incretin hormone and insulin secretory responses to oral and "isoglycemic" intravenous glucose

8 September 2018

1 reference

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Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.

8 September 2018

1 reference

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An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

8 September 2018

1 reference

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Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

8 September 2018

1 reference

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Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry.

8 September 2018

1 reference

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Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes.

8 September 2018

1 reference

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Mechanisms underlying metformin-induced secretion of glucagon-like peptide-1 from the intestinal L cell

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6104807

Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6104807

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6104807

Neuronal regulation of homeostasis by nutrient sensing

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6104807

Intestinal cholecystokinin controls glucose production through a neuronal network

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6104807

Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6104807

Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6104807

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6104807

Pharmacokinetic-pharmacodynamic analysis of the glucose-lowering effect of metformin in diabetic rats reveals first-pass pharmacodynamic effect

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6104807

Role of AMP-activated protein kinase in mechanism of metformin action

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6104807

Mechanism by which metformin reduces glucose production in type 2 diabetes

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6104807

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6104807

Deconstructing type 2 diabetes

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6104807

Metabolic effects of metformin in non-insulin-dependent diabetes mellitus

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6104807

GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress

8 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25849133

12 December 2020

inferred from PubMed ID database lookup

Effects of metformin on lactate uptake and gluconeogenesis in the perfused rat liver

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25849133

12 December 2020

inferred from PubMed ID database lookup

Duodenal activation of cAMP-dependent protein kinase induces vagal afferent firing and lowers glucose production in rats

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25849133

12 December 2020

inferred from PubMed ID database lookup

Meta-analysis: metformin treatment in persons at risk for diabetes mellitus

1 reference

7 January 2021

Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation

1 reference

7 January 2021

The selectivity of protein kinase inhibitors: a further update

1 reference

7 January 2021

Cellular and molecular mechanisms of metformin: an overview

1 reference

7 January 2021

LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin

1 reference

7 January 2021

Overcoming Drug Development Bottlenecks With Repurposing: Repurposing biguanides to target energy metabolism for cancer treatment

1 reference

7 January 2021

Metformin improves healthspan and lifespan in mice

1 reference

7 January 2021

Accumulation of metformin by tissues of the normal and diabetic mouse

1 reference

7 January 2021

Overfeeding rapidly induces leptin and insulin resistance

1 reference

7 January 2021

Insulin activates Erk1/2 signaling in the dorsal vagal complex to inhibit glucose production.

1 reference

7 January 2021

Duodenal mucosal protein kinase C-δ regulates glucose production in rats

1 reference

7 January 2021

Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression

1 reference

7 January 2021

Dose-independent pharmacokinetics of metformin in rats: Hepatic and gastrointestinal first-pass effects

1 reference

7 January 2021

Clinical Pharmacokinetics of Metformin

1 reference

7 January 2021

Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

1 reference

7 January 2021

1 reference

7 January 2021

Identifiers

DOI

10.1038/NM.3787

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25849133%20AND%20SRC:MED&resulttype=core&format=json

release_5lqcr46zn5gzvptymmcwczaksm

4 March 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/5lqcr46zn5gzvptymmcwczaksm

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25849133%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

PubMed publication ID

25849133

1 reference