The tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-beta (Abeta) degradation and inhibits Abeta-induced neurodegeneration. (Q48182042)

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English	The tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-beta (Abeta) degradation and inhibits Abeta-induced neurodegeneration.	scientific article

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scholarly article

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19 December 2019

The tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-beta (Abeta) degradation and inhibits Abeta-induced neurodegeneration (English)

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19 December 2019

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Sidney Strickland

3

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19 December 2019

author name string

Jerry P Melchor

1

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19 December 2019

Robert Pawlak

2

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19 December 2019

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1 October 2003

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19 December 2019

Journal of Neuroscience

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23

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26

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19 December 2019

8867-8871

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19 December 2019

Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in mice

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12 December 2020

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Enhanced hippocampal long-term potentiation and learning by increased neuronal expression of tissue-type plasminogen activator in transgenic mice

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12 December 2020

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Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease

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12 December 2020

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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12 December 2020

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Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background

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https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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The plasmin system is induced by and degrades amyloid-beta aggregates

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12 December 2020

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Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

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https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration

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https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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Tissue plasminogen activator requires plasminogen to modulate amyloid-beta neurotoxicity and deposition

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https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer's disease brains

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https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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Clearing the brain's amyloid cobwebs

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https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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Ham-Wasserman lecture: role of the plasminogen system in fibrin-homeostasis and tissue remodeling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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Fibrin inhibits peripheral nerve remyelination by regulating Schwann cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

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Tissue plasminogen activator and seizures: a clot-buster's secret life

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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Accumulation of Type 1 Plasminogen Activator Inhibitor and Vitronectin at Sites of Cellular Necrosis and Inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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Platelet protease nexin-2/amyloid beta-protein precursor. Possible pathologic and physiologic functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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Amiloride selectively inhibits the urokinase-type plasminogen activator

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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In vitro stimulation of tissue-type plasminogen activator by Alzheimer amyloid beta-peptide analogues.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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Plasminogen activator inhibitor-1 in the cerebrospinal fluid as an index of neurological disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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Extracellular proteolysis in the adult murine brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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Tissue-plasminogen activator is induced as an immediate-early gene during seizure, kindling and long-term potentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

based on heuristic

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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Neuronal cell death and tPA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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Amyloid beta-protein (Abeta) 1-40 but not Abeta1-42 contributes to the experimental formation of Alzheimer disease amyloid fibrils in rat brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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Tissue plasminogen activator contributes to the late phase of LTP and to synaptic growth in the hippocampal mossy fiber pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523088

12 December 2020

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Identifiers

10.1523/JNEUROSCI.23-26-08867.2003

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14523088%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14523088%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14523088%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

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