PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation. (Q48181965)

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English	PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation.	scientific article

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19 December 2019

PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation (English)

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19 December 2019

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Christian Czech

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19 December 2019

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J Grayson Richards

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19 December 2019

Guy A Higgins

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19 December 2019

Abdel-Mouttalib Ouagazzal

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19 December 2019

Laurence Ozmen

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19 December 2019

James N C Kew

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19 December 2019

Bernd Bohrmann

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19 December 2019

Pari Malherbe

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19 December 2019

Manfred Brockhaus

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19 December 2019

Hansruedi Loetscher

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19 December 2019

Gerda Huber

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19 December 2019

Horst Bluethmann

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19 December 2019

Helmut Jacobsen

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19 December 2019

John A Kemp

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19 December 2019

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1 October 2003

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19 December 2019

Journal of Neuroscience

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19 December 2019

23

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19 December 2019

8989-9003

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19 December 2019

26

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19 December 2019

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

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https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein

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https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice.

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https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ibotenate lesions of the hippocampus impair spatial learning but not contextual fear conditioning in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional consequences of reduction in NMDA receptor glycine affinity in mice carrying targeted point mutations in the glycine binding site

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

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https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD45 opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: genes, proteins, and therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

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Correlation between cognitive deficits and Abeta deposits in transgenic APP+PS1 mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

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Influence of the selective ORL1 receptor agonist, Ro64-6198, on rodent neurological function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

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In-vivo measurement of activated microglia in dementia

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic mouse models of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reelin in plaques of beta-amyloid precursor protein and presenilin-1 double-transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-independent and age-related deficits in visuospatial learning, sleep-wake states, thermoregulation and motor activity in PDAPP mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progressive age-related impairment of cognitive behavior in APP23 transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-dependent cognitive decline in the APP23 model precedes amyloid deposition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intact spatial memory in mice with seizure-induced partial lossof hippocampal pyramidal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic mouse models of Alzheimer's disease: phenotype and application

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversible in vitro growth of Alzheimer disease beta-amyloid plaques by deposition of labeled amyloid peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Entorhinal cortex pathology in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoreactivity of CD45, a protein phosphotyrosine phosphatase, in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue-specific control elements of the Thy-1 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The quantification of brain lesions with an omega 3 site ligand: a critical analysis of animal models of cerebral ischaemia and neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A modified cupric-silver technique for the impregnation of degenerating neurons and their processes

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial tyrosine phosphorylation systems in normal and degenerating brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of aging on spatial learning and hippocampal protein kinase C in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of APP in transgenic mice: a comparison of neuron-specific promoters.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hippocampal lesions cause learning deficits in inbred mice in the Morris water maze and conditioned-fear task.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A vector for expressing foreign genes in the brains and hearts of transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for recovery of spatial learning following entorhinal cortex lesions in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilins are processed by caspase-type proteases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absence of central cholinergic deficits in ApoE knockout mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frequency of stages of Alzheimer-related lesions in different age categories

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14523101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.23-26-08989.2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14523101%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14523101%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14523101%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

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