A Cyclic Altered Peptide Analogue Based on Myelin Basic Protein 87-99 Provides Lasting Prophylactic and Therapeutic Protection Against Acute Experimental Autoimmune Encephalomyelitis. (Q48134008)

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scientific article published on 31 January 2018

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English	A Cyclic Altered Peptide Analogue Based on Myelin Basic Protein 87-99 Provides Lasting Prophylactic and Therapeutic Protection Against Acute Experimental Autoimmune Encephalomyelitis.	scientific article published on 31 January 2018

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scholarly article

1 reference

Europe PubMed Central

9 February 2018

http://europepmc.org/abstract/MED/29385090

A Cyclic Altered Peptide Analogue Based on Myelin Basic Protein 87-99 Provides Lasting Prophylactic and Therapeutic Protection Against Acute Experimental Autoimmune Encephalomyelitis (English)

1 reference

Europe PubMed Central

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12 May 2020

6

1 reference

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12 May 2020

author name string

Mary Emmanouil

1

1 reference

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12 May 2020

Vivian Tseveleki

2

1 reference

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12 May 2020

Iro Triantafyllakou

3

1 reference

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12 May 2020

Agathi Nteli

4

1 reference

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12 May 2020

Theodore Tselios

5

1 reference

Europe PubMed Central

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12 May 2020

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publication date

31 January 2018

1 reference

Europe PubMed Central

9 February 2018

http://europepmc.org/abstract/MED/29385090

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6017753&resulttype=core&format=json

12 May 2020

23

1 reference

Europe PubMed Central

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12 May 2020

2

1 reference

Europe PubMed Central

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12 May 2020

copyright license

Creative Commons Attribution 4.0 International

31 January 2018

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April 2022 Public Data File from Crossref

copyright status

0 references

Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myelin basic protein‐specific T lymphocyte lines from MS patients and healthy individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon gamma and tumor necrosis factor alpha production

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential activation of human autoreactive T cell clones by altered peptide ligands derived from myelin basic protein peptide (87-99)

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Manipulation of the Th1/Th2 balance in autoimmune disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amelioration of relapsing experimental autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients. Identity of key contact residues in the B-cell and T-cell epitopes

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of a non-encephalitogenic type 2 T helper-cell autoimmune responsein multiple sclerosis after administration of an altered peptide ligand ina placebo-controlled, randomized phase II trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The molecular basis of T helper 1 and T helper 2 cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of experimental allergic encephalomyelitis (EAE) by a rationally designed cyclic analogue of myelin basic protein (MBP) epitope 72-85.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antagonistic Effects of Human Cyclic MBP87-99Altered Peptide Ligands in Experimental Allergic Encephalomyelitis and Human T-Cell Proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expansion and functional relevance of high-avidity myelin-specific CD4+ T cells in multiple sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design and synthesis of a novel potent myelin basic protein epitope 87-99 cyclic analogue: enhanced stability and biological properties of mimics render them a potentially new class of immunomodulators.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural requirements for binding of myelin basic protein (MBP) peptides to MHC II: effects on immune regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular dynamics at the receptor level of immunodominant myelin basic protein epitope 87–99 implicated in multiple sclerosis and its antagonists altered peptide ligands: Triggering of immune response

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design of novel cyclic altered peptide ligands of myelin basic protein MBP83-99 that modulate immune responses in SJL/J mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel therapeutic strategies for multiple sclerosis--a multifaceted adversary

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design and Synthesis of a Cyclic Double Mutant Peptide (cyclo(87−99)[A91,A96]MBP87−99) Induces Altered Responses in Mice after Conjugation to Mannan: Implications in the Immunotherapy of Multiple Sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differentiation of effector CD4 T cell populations (*)

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microwave-assisted solid-phase peptide synthesis of the 60-110 domain of human pleiotrophin on 2-chlorotrityl resin

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction and molecular signature of pathogenic TH17 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antigen-specific tolerance by autologous myelin peptide-coupled cells: a phase 1 trial in multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Using EAE to better understand principles of immune function and autoimmune pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Divergent and convergent synthesis of polymannosylated dibranched antigenic peptide of the immunodominant epitope MBP(83–99)

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of white matter damage in multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extra-thymically induced T regulatory cell subsets: the optimal target for antigen-specific immunotherapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Review cyclic peptides on a merry-go-round; towards drug design

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Properties of myelin altered peptide ligand cyclo(87-99)(Ala91,Ala96)MBP87-99 render it a promising drug lead for immunotherapy of multiple sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of the 2-chlorotrityl chloride resin for microwave-assisted solid phase peptide synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29385090

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3390/MOLECULES23020304

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6017753&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6017753&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6017753&resulttype=core&format=json

12 May 2020

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