Insulin regulation of the Ras activation/inactivation cycle. (Q48021751)

7 February 2018

review article

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title

Insulin regulation of the Ras activation/inactivation cycle. (English)

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7 February 2018

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B P Ceresa

1

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7 February 2018

J E Pessin

series ordinal

2

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7 February 2018

publication date

1 May 1998

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7 February 2018

Molecular and Cellular Biochemistry

published in

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7 February 2018

volume

182

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7 February 2018

page(s)

23-29

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7 February 2018

issue

1-2

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7 February 2018

https://scigraph.springernature.com/pub.10.1023/a:1006819008507

exact match

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cites work

JAK1 kinase forms complexes with interleukin-4 receptor and 4PS/insulin receptor substrate-1-like protein and is activated by interleukin-4 and interleukin-9 in T lymphocytes

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12 December 2020

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

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12 December 2020

Insulin and epidermal growth factor receptors regulate distinct pools of Grb2-SOS in the control of Ras activation

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12 December 2020

Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors

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12 December 2020

Activation of mitogen-activated protein kinase and phosphatidylinositol 3'-kinase is not sufficient for the hormonal stimulation of glucose uptake, lipogenesis, or glycogen synthesis in 3T3-L1 adipocytes

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12 December 2020

Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway

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12 December 2020

Function of Ras as a molecular switch in signal transduction

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12 December 2020

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

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12 December 2020

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.

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12 December 2020

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

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12 December 2020

The insulin-dependent biosynthesis of GLUT1 and GLUT3 glucose transporters in L6 muscle cells is mediated by distinct pathways. Roles of p21ras and pp70 S6 kinase

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12 December 2020

Negative feedback regulation and desensitization of insulin- and epidermal growth factor-stimulated p21ras activation

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12 December 2020

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase.

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12 December 2020

An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth

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12 December 2020

Signal transduction pathways from insulin receptors to Ras. Analysis by mutant insulin receptors.

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12 December 2020

Association between GRB2/Sos and insulin receptor substrate 1 is not sufficient for activation of extracellular signal-regulated kinases by interleukin-4: implications for Ras activation by insulin

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12 December 2020

Insulin signal transduction and the IRS proteins

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12 December 2020

An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control

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12 December 2020

Role of p21ras in insulin-stimulated glucose transport in 3T3-L1 adipocytes.

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12 December 2020

Insulin action and the insulin signaling network

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12 December 2020

Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras

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12 December 2020

Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2

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12 December 2020

Insulin activates p21Ras and guanine nucleotide releasing factor in cells expressing wild type and mutant insulin receptors.

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12 December 2020

Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2

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12 December 2020

Diverse signaling pathways in the cellular actions of insulin

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12 December 2020

Insulin receptor substrate 1 and 2 (IRS1 and IRS2): what a tangled web we weave.

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12 December 2020

The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product

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12 December 2020

Epidermal Growth Factor Receptor Targeting Prevents Uncoupling of the Grb2-SOS Complex

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12 December 2020

Disassembly of Son-of-sevenless proteins from Grb2 during p21ras desensitization by insulin

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12 December 2020

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

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12 December 2020

The nature and regulation of the insulin receptor: structure and function

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12 December 2020

Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation.

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12 December 2020

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation

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12 December 2020

Desensitization of Ras activation by a feedback disassociation of the SOS-Grb2 complex

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12 December 2020

PHAS-I as a link between mitogen-activated protein kinase and translation initiation

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12 December 2020

A dominant-negative mutant of mSOS1 inhibits insulin-induced Ras activation and reveals Ras-dependent and -independent insulin signaling pathways

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12 December 2020

Shc isoform-specific tyrosine phosphorylation by the insulin and epidermal growth factor receptors

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12 December 2020

Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6

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12 December 2020

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

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12 December 2020

Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes

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12 December 2020

Activation of the Ras/mitogen-activated protein kinase signaling pathway alone is not sufficient to induce glucose uptake in 3T3-L1 adipocytes

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12 December 2020

Characterization of the mitogen-activated protein kinase/90-kilodalton ribosomal protein S6 kinase signaling pathway in 3T3-L1 adipocytes and its role in insulin-stimulated glucose transport

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12 December 2020

GTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells.

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12 December 2020

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12 December 2020

Insulin stimulation of a MEK-dependent but ERK-independent SOS protein kinase

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12 December 2020

Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras

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12 December 2020

Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

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12 December 2020

Downregulation of the Ras activation pathway by MAP kinase phosphorylation of Sos.

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12 December 2020

The ras signaling pathway mimics insulin action on glucose transporter translocation

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12 December 2020

Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression.

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12 December 2020

Complex formation between RAS and RAF and other protein kinases

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12 December 2020

The function of GRB2 in linking the insulin receptor to Ras signaling pathways

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12 December 2020

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

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12 December 2020

A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP forma

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12 December 2020

Differential requirement for p21ras activation in the metabolic signaling by insulin.

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12 December 2020

Activation of ternary complex factor Elk-1 by MAP kinases

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12 December 2020

Insulin receptor substrate-1 (IRS1) and Shc compete for a limited pool of Grb2 in mediating insulin downstream signaling

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12 December 2020

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling

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12 December 2020

Mammalian Ras interacts directly with the serine/threonine kinase Raf

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12 December 2020

Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins.

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12 December 2020

Ras target proteins in eukaryotic cells

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12 December 2020

Divergent mechanisms for homologous desensitization of p21ras by insulin and growth factors

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12 December 2020

Functional divergence of the MAP kinase pathway. ERK1 and ERK2 activate specific transcription factors

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12 December 2020

Integration of MAP kinase signal transduction pathways at the serum response element

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12 December 2020

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

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12 December 2020

Ligand-dependent intersubunit association within the insulin receptor complex activates its intrinsic kinase activity

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12 December 2020

Regulatory mechanisms for ras proteins

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12 December 2020

Role of IRS-2 in insulin and cytokine signalling

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12 December 2020

Insulin-stimulated disassociation of the SOS-Grb2 complex

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12 December 2020

Insulin stimulation of gene expression mediated by p21ras activation.

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12 December 2020

Role of IRS-1-GRB-2 complexes in insulin signaling

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12 December 2020

Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

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12 December 2020

Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation

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12 December 2020

Ras signaling in the activation of glucose transport by insulin

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12 December 2020

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

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12 December 2020

MAP kinase phosphorylation of mSos1 promotes dissociation of mSos1-Shc and mSos1-EGF receptor complexes.

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12 December 2020

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

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12 December 2020

Insulin stimulates the phosphorylation of the 66- and 52-kilodalton Shc isoforms by distinct pathways

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12 December 2020

Identifiers

DOI

10.1023/A:1006819008507

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7 February 2018

Dimensions Publication ID

0 references

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7 February 2018