By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice. (Q35955419)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

title

By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

main subject

hepatocellular carcinoma

1 reference

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

24

Yingqun Zhou

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

6

Kan Chen

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1

Weiqi Dai

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

4

Yujing Xia

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

10

Yuanyuan Zheng

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

22

Chengfen Wang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

12

Wenxia Lu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

Huerxidan Abudumijiti

15

object named as

Huerxidan Abudumijiti

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

16

Rongxia Chen

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

20

Rong Zhu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

author name string

Fan Wang

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

Jie Lu

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

Lei He

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

Jingjing Li

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

Sainan Li

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

Tong Liu

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

Jianrong Wang

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

Yuqing Zhou

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

Qin Yin

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

Rong Zhang

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

Li Zhou

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

Zheng Zhou

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

Jing Yang

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

Huawei Zhang

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

Ling Xu

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

language of work or name

English

0 references

publication date

1 May 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

volume

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

page(s)

13703-13717

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

issue

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

Diagnostic Performance of Des-γ-carboxy Prothrombin for Hepatocellular Carcinoma: A Meta-Analysis

7 March 2020

cites work

1 reference

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The synergistic in vitro and in vivo antitumor effect of combination therapy with salinomycin and 5-fluorouracil against hepatocellular carcinoma

2 October 2017

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Anti-miR-197 inhibits migration in HCC cells by targeting KAI 1/CD82.

2 October 2017

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2 October 2017

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Ethyl pyruvate inhibits proliferation and induces apoptosis of hepatocellular carcinoma via regulation of the HMGB1-RAGE and AKT pathways.

2 October 2017

1 reference

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Genistein inhibits hepatocellular carcinoma cell migration by reversing the epithelial-mesenchymal transition: partial mediation by the transcription factor NFAT1.

2 October 2017

1 reference

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Resveratrol contributes to chemosensitivity of malignant mesothelioma cells with activation of p53.

2 October 2017

1 reference

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Resveratrol suppresses cancer cell glucose uptake by targeting reactive oxygen species-mediated hypoxia-inducible factor-1α activation

2 October 2017

1 reference

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Resveratrol and P-glycoprotein inhibitors enhance the anti-skin cancer effects of ursolic acid.

2 October 2017

1 reference

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The hippo-yes association protein pathway in liver cancer

2 October 2017

1 reference

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Resveratrol decreases breast cancer cell viability and glucose metabolism by inhibiting 6-phosphofructo-1-kinase.

2 October 2017

1 reference

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Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil: a new family of gerosuppressant agents

2 October 2017

1 reference

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Activating oxidative phosphorylation by a pyruvate dehydrogenase kinase inhibitor overcomes sorafenib resistance of hepatocellular carcinoma

2 October 2017

1 reference

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Resveratrol inhibits cancer cell metabolism by down regulating pyruvate kinase M2 via inhibition of mammalian target of rapamycin

2 October 2017

1 reference

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3-Bromopyruvate: targets and outcomes

2 October 2017

1 reference

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A metabolic perturbation by U0126 identifies a role for glutamine in resveratrol-induced cell death

2 October 2017

1 reference

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Resveratrol induces p53-independent, X-linked inhibitor of apoptosis protein (XIAP)-mediated Bax protein oligomerization on mitochondria to initiate cytochrome c release and caspase activation.

2 October 2017

1 reference

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Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation

2 October 2017

1 reference

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

2 October 2017

1 reference

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Control of mitochondrial apoptosis by the Bcl-2 family

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537043

BCL-2 family proteins: critical checkpoints of apoptotic cell death

2 October 2017

1 reference

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Molecular mechanisms of resveratrol action in lung cancer cells using dual protein and microarray analyses

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537043

Glucose phosphorylation and mitochondrial binding are required for the protective effects of hexokinases I and II.

2 October 2017

1 reference

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Resveratrol inhibits glucose metabolism in human ovarian cancer cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537043

Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent

2 October 2017

1 reference

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Resveratrol-induced cell inhibition of growth and apoptosis in MCF7 human breast cancer cells are associated with modulation of phosphorylated Akt and caspase-9.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537043

Inhibition of phosphatidylinositol 3-kinase-mediated glucose metabolism coincides with resveratrol-induced cell cycle arrest in human diffuse large B-cell lymphomas

2 October 2017

1 reference

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Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak

2 October 2017

1 reference

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Why do cancers have high aerobic glycolysis?

2 October 2017

1 reference

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Beginnings of a signal-transduction pathway for bioenergetic control of cell survival

2 October 2017

1 reference

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On the Origin of Cancer Cells

2 October 2017

1 reference

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Involvement of p21WAF1/CIP1, pRB, Bax and NF-kappaB in induction of growth arrest and apoptosis by resveratrol in human lung carcinoma A549 cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537043

Resveratrol increases BRCA1 and BRCA2 mRNA expression in breast tumour cell lines

2 October 2017

1 reference

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Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537043

Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537043

Resveratrol, a natural phenolic compound, inhibits cell proliferation and prevents oxidative DNA damage.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537043

Hexokinase expression in liver preneoplasia and neoplasia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537043

Resolution of the direct interaction with and inhibition of the human GLUT1 hexose transporter by resveratrol from its effect on glucose accumulation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537043

Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537043

Efficacy and safety of sorafenib in advanced hepatocellular carcinoma under daily practice conditions

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537043

Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: the roles of caspase-6 and p53.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537043

Resveratrol, an ingredient of wine, acts synergistically with Ara-C and tiazofurin in HL-60 human promyelocytic leukemia cells.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537043

Energy metabolism of human LoVo colon carcinoma cells: correlation to drug resistance and influence of lonidamine.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537043

Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25938543

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inhibition of Akt Reverses the Acquired Resistance to Sorafenib by Switching Protective Autophagy to Autophagic Cell Death in Hepatocellular Carcinoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25938543

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Higher discontinuation and lower survival rates are likely in elderly Japanese patients with advanced hepatocellular carcinoma receiving sorafenib

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25938543

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.3800

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938543%20AND%20SRC:MED&resulttype=core&format=json