Combination of Emricasan with Ponatinib Synergistically Reduces Ischemia/Reperfusion Injury in Rat Brain Through Simultaneous Prevention of Apoptosis and Necroptosis. (Q47441236)

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scientific article published on 4 November 2017

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English	Combination of Emricasan with Ponatinib Synergistically Reduces Ischemia/Reperfusion Injury in Rat Brain Through Simultaneous Prevention of Apoptosis and Necroptosis.	scientific article published on 4 November 2017

Statements

scholarly article

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29103102

Combination of Emricasan with Ponatinib Synergistically Reduces Ischemia/Reperfusion Injury in Rat Brain Through Simultaneous Prevention of Apoptosis and Necroptosis. (English)

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29103102

reperfusion injury

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Jing Tian

1

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29103102

Shu Guo

2

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29103102

Heng Chen

3

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29103102

Jing-Jie Peng

4

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29103102

Miao-Miao Jia

5

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29103102

Nian-Sheng Li

6

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29103102

Xiao-Jie Zhang

7

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29103102

Jie Yang

8

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29103102

Xiu-Ju Luo

9

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29103102

Jun Peng

10

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29103102

publication date

4 November 2017

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29103102

Translational stroke research

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29103102

https://scigraph.springernature.com/pub.10.1007/s12975-017-0581-z

0 references

Acute Ischemic Stroke Therapy Overview

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Revisiting cerebral postischemic reperfusion injury: new insights in understanding reperfusion failure, hemorrhage, and edema

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Pathogenic mechanisms following ischemic stroke

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Caspases Connect Cell-Death Signaling to Organismal Homeostasis

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Apoptosis: a review of programmed cell death

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Targeting caspase-6 and caspase-8 to promote neuronal survival following ischemic stroke.

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Caspase mRNA expression in a rat model of focal cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Total saponins of Panax notoginseng modulate the expression of caspases and attenuate apoptosis in rats following focal cerebral ischemia-reperfusion

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

The combination of isoflurane and caspase 8 inhibition results in sustained neuroprotection in rats subject to focal cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

The pan-caspase inhibitor Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis.

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

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Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease

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The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Regulated necrosis: disease relevance and therapeutic opportunities

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https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Regulated necrosis: the expanding network of non-apoptotic cell death pathways.

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Necroptosis: A Novel Cell Death Modality and Its Potential Relevance for Critical Care Medicine.

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Hypoxia-inducible factor-1 alpha is involved in RIP-induced necroptosis caused by in vitro and in vivo ischemic brain injury

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis.

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis.

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Alda-1 reduces cerebral ischemia/reperfusion injury in rat through clearance of reactive aldehydes

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Experimental model of small deep infarcts involving the hypothalamus in rats: changes in body temperature and postural reflex

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Transient and permanent resolution of ischemic lesions on diffusion-weighted imaging after brief periods of focal ischemia in rats : correlation with histopathology.

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

The synergetic effect of edaravone and borneol in the rat model of ischemic stroke.

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https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Progesterone in transient ischemic stroke: a dose-response study

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https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Protocol for middle cerebral artery occlusion by an intraluminal suture method

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https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Hydroxysafflor yellow A protects neuron against hypoxia injury and suppresses inflammatory responses following focal ischemia reperfusion in rats

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https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Behavioral and histologic neuroprotection of aqueous garlic extract after reversible focal cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Neuroprotection by hyperbaric oxygenation after experimental focal cerebral ischemia monitored by MRI.

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Caspase mechanisms

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Articulatin-D induces apoptosis via activation of caspase-8 in acute T-cell leukemia cell line

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Cutting edge: innate immunity conferred by B cells is regulated by caspase-8.

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

The in vivo evidence for regulated necrosis

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Necroptosis in neurodegenerative diseases: a potential therapeutic target

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Necrostatin-1 protects hippocampal neurons against ischemia/reperfusion injury via the RIP3/DAXX signaling pathway in rats.

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Non-Alcoholic Steatohepatitis: Limited Available Treatment Options but Promising Drugs in Development and Recent Progress Towards a Regulatory Approval Pathway

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Effects of 31 FDA approved small-molecule kinase inhibitors on isolated rat liver mitochondria

1 reference

https://api.crossref.org/works/10.1007%2FS12975-017-0581-Z

21 January 2018

Reduced neuronal nitric oxide synthase is involved in ischemia-induced hippocampal neurogenesis by up-regulating inducible nitric oxide synthase expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/29103102

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistant mutations in CML and Ph(+)ALL - role of ponatinib.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29103102

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-8 and caspase-3 are expressed by different populations of cortical neurons undergoing delayed cell death after focal stroke in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29103102

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment and molecular monitoring update in chronic myeloid leukemia management.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29103102

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical trial: the efficacy and safety of oral PF-03491390, a pancaspase inhibitor - a randomized placebo-controlled study in patients with chronic hepatitis C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29103102

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical Trial of the Pan-Caspase Inhibitor, IDN-6556, in Human Liver Preservation Injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/29103102

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S12975-017-0581-Z

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29103102

1 reference

Europe PubMed Central

16 January 2018

http://europepmc.org/abstract/MED/29103102

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