G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in&#160;vitro and in&#160;vivo. (Q47428803)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29113975%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

title

G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo (English)

1 reference

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amyotrophic lateral sclerosis

9 April 2020

main subject

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27

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Rickie Patani

31

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Thomas G Moens

3

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Amanda Heslegrave

6

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Nathaniel S Woodling

7

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Teresa Niccoli

8

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Mica Clarke

12

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Mohamed A. Ismail

20

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Stephen Neidle

30

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Pietro Fratta

32

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Adrian M Isaacs

33

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26

Henrik Zetterberg

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9 April 2020

author name string

Roberto Simone

1

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Rubika Balendra

2

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Elisavet Preza

4

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Katherine M Wilson

5

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Javier Gilbert-Jaramillo

9

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Samir Abdelkarim

10

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Emma L Clayton

11

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Marie-Therese Konrad

13

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Andrew J Nicoll

14

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Jamie S Mitchell

15

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Andrea Calvo

16

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Henry Houlden

18

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James M Polke

19

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Chad E Stephens

21

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Tam Vo

22

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9 April 2020

Abdelbasset A Farahat

23

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W David Wilson

24

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David W Boykin

25

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Selina Wray

28

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Gary Parkinson

29

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Adriano Chio

17

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publication date

1 January 2018

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9 April 2020

published in

EMBO Molecular Medicine

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9 April 2020

volume

10

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9 April 2020

issue

1

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9 April 2020

page(s)

22-31

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describes a project that uses

9 April 2020

ImageQuant

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11 June 2022

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ImageJ

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22 May 2018

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Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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Synthesis and evaluation of analogues of 10H-indolo[3,2-b]quinoline as G-quadruplex stabilising ligands and potential inhibitors of the enzyme telomerase.

22 May 2018

1 reference

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Characterization of DNA G-quadruplex species forming from C9ORF72 G4C2-expanded repeats associated with amyotrophic lateral sclerosis and frontotemporal lobar degeneration

22 May 2018

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Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins

14 August 2018

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The steroid hormone receptor EcR finely modulates Drosophila lifespan during adulthood in a sex-specific manner.

14 August 2018

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Synthesis, biophysical and biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as potent G-quadruplex-binding telomerase inhibitors.

14 August 2018

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14 August 2018

Identifiers

DOI

10.15252/EMMM.201707850

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29113975%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

1 reference

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9 April 2020

PubMed publication ID

29113975

1 reference