Discovery of a biomarker and lead small molecules to target r(GGGGCC)-associated defects in c9FTD/ALS. (Q34512451)

2 August 2017

Discovery of a biomarker and lead small molecules to target r(GGGGCC)-associated defects in c9FTD/ALS. (English)

1 reference

amyotrophic lateral sclerosis

2 August 2017

0 references

1 reference

1 reference

18

1 reference

2 August 2017

Peter O Bauer

4

0 references

Vincenzo Silani

object named as

Vincenzo Silani

23

0 references

Leonard Petrucelli

28

object named as

Leonard Petrucelli

1 reference

2 August 2017

24

Rosa Rademakers

1 reference

2 August 2017

16

Merit E Cudkowicz

1 reference

2 August 2017

20

Bryan J Traynor

1 reference

2 August 2017

17

Bradley F Boeve

1 reference

2 August 2017

25

Robert H Brown

1 reference

2 August 2017

Zhaoming Su

1

1 reference

2 August 2017

Yongjie Zhang

2

1 reference

2 August 2017

Tania F Gendron

3

1 reference

2 August 2017

Jeannie Chew

5

1 reference

2 August 2017

Wang-Yong Yang

6

1 reference

2 August 2017

Erik Fostvedt

7

1 reference

2 August 2017

Karen Jansen-West

8

1 reference

2 August 2017

Veronique V Belzil

9

1 reference

2 August 2017

Pamela Desaro

10

1 reference

2 August 2017

Amelia Johnston

11

1 reference

2 August 2017

Karen Overstreet

12

1 reference

2 August 2017

Seok-Yoon Oh

13

1 reference

2 August 2017

Peter K Todd

14

1 reference

2 August 2017

James D Berry

15

1 reference

2 August 2017

Mary Kay Floeter

19

1 reference

2 August 2017

Claudia Morelli

21

1 reference

2 August 2017

Antonia Ratti

22

1 reference

2 August 2017

Jeffrey D Rothstein

26

1 reference

2 August 2017

Kevin B Boylan

27

1 reference

2 August 2017

Matthew D Disney

29

1 reference

2 August 2017

language of work or name

English

0 references

publication date

14 August 2014

1 reference

2 August 2017

1 reference

2 August 2017

83

1 reference

2 August 2017

1043-1050

1 reference

2 August 2017

5

1 reference

C9orf72 nucleotide repeat structures initiate molecular cascades of disease.

2 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232217

Sequence-based design of bioactive small molecules that target precursor microRNAs

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232217

Mechanisms of toxicity in C9FTLD/ALS.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232217

RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232217

Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232217

RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232217

Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232217

Covalent small-molecule-RNA complex formation enables cellular profiling of small-molecule-RNA interactions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232217

G-quadruplex structures are stable and detectable in human genomic DNA.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232217

The disease-associated r(GGGGCC)n repeat from the C9orf72 gene forms tract length-dependent uni- and multimolecular RNA G-quadruplex structures

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232217

Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD/ALS

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232217

The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232217

Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232217

C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232217

A small molecule that targets r(CGG)(exp) and improves defects in fragile X-associated tremor ataxia syndrome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232217

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232217

Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232217

Use of dimethyl sulfate to probe RNA structure in vivo

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232217

Following G-quartet formation by UV-spectroscopy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232217

Cation-dependent transition between the quadruplex and Watson-Crick hairpin forms of d(CGCG3GCG)

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232217

TMPyP4 porphyrin distorts RNA G-quadruplex structures of the disease-associated r(GGGGCC)n repeat of the C9orf72 gene and blocks interaction of RNA-binding proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232217

Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232217

An RNA hairpin to G-quadruplex conformational transition.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232217

10.1016/J.NEURON.2014.07.041

27 October 2018

Identifiers

DOI

1 reference

2 August 2017

1 reference

2 August 2017

1 reference