Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease (Q34651971)

3 August 2017

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title

Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease (English)

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3 August 2017

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Kumar Sambamurti

1

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3 August 2017

Nigel H Greig

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2

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3 August 2017

Debomoy K Lahiri

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3

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3 August 2017

1 January 2002

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3 August 2017

NeuroMolecular Medicine

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3 August 2017

1

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3 August 2017

1-31

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3 August 2017

1

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https://scigraph.springernature.com/pub.10.1385/nmm:1:1:1

3 August 2017

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cites work

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

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12 December 2020

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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12 December 2020

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

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12 December 2020

Processing of amyloid precursor protein in human primary neuron and astrocyte cultures.

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12 December 2020

Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.

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12 December 2020

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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12 December 2020

Generation and regulation of beta-amyloid peptide variants by neurons.

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12 December 2020

Antibody-regulated neurotoxic function of cell-surface beta-amyloid precursor protein

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12 December 2020

Protein topology of presenilin 1

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12 December 2020

The promoter of Alzheimer's disease amyloid A4 precursor gene

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12 December 2020

Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors.

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12 December 2020

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

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12 December 2020

Secretion of beta-amyloid precursor protein involves multiple cleavage sites

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12 December 2020

Purification and cloning of amyloid precursor protein beta-secretase from human brain

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12 December 2020

Selective loss of central cholinergic neurons in Alzheimer's disease

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12 December 2020

Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development

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12 December 2020

Cell surface amyloid beta-protein precursor colocalizes with beta 1 integrins at substrate contact sites in neural cells

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12 December 2020

Tau epitopes are incorporated into a range of lesions in Alzheimer's disease.

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12 December 2020

Phosphorylation of the beta-amyloid precursor protein at the cell surface by ectocasein kinases 1 and 2

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12 December 2020

Protease nexin-II (amyloid beta-protein precursor): a platelet alpha-granule protein

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12 December 2020

Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells

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12 December 2020

LSF and NTF-1 share a conserved DNA recognition motif yet require different oligomerization states to form a stable protein-DNA complex.

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12 December 2020

beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms.

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12 December 2020

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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12 December 2020

cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein

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12 December 2020

Novel regulation of chondroitin sulfate glycosaminoglycan modification of amyloid precursor protein and its homologue, APLP2

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12 December 2020

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

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12 December 2020

Glycosylphosphatidylinositol-anchored proteins play an important role in the biogenesis of the Alzheimer's amyloid beta-protein

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12 December 2020

Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts

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12 December 2020

Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway

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12 December 2020

Modulation of amyloid precursor protein metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein interaction domains.

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12 December 2020

ADAM17 but not ADAM10 mediates tumor necrosis factor-alpha and L-selectin shedding from leukocyte membranes

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12 December 2020

Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide

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12 December 2020

Differential regulation of APP secretion by apolipoprotein E3 and E4

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12 December 2020

β-Amyloid precursor protein gene is differentially expressed in axotomized sensory and motor systems

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12 December 2020

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

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12 December 2020

The Alzheimer's Amyloid Precursor Is Cleaved Intracellularly in the Trans‐Golgi Network or in a Post‐Golgi Compartment a

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12 December 2020

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

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12 December 2020

Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor

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12 December 2020

Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.

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12 December 2020

The role of apolipoprotein E in Alzheimer's disease: pharmacogenomic target selection

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12 December 2020

Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion

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12 December 2020

Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease.

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12 December 2020

The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein

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12 December 2020

The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein

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12 December 2020

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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12 December 2020

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein

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12 December 2020

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12 December 2020

Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion

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12 December 2020

Characterization of beta-amyloid peptide precursor processing by the yeast Yap3 and Mkc7 proteases.

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12 December 2020

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

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12 December 2020

APP gene promoter constructs are preferentially expressed in the CNS and testis of transgenic mice.

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12 December 2020

The cytoskeleton in Alzheimer disease.

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12 December 2020

A novel method for making nested deletions and its application for sequencing of a 300 kb region of human APP locus

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12 December 2020

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

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12 December 2020

Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann-pick type C cells

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12 December 2020

GM1 ganglioside-bound amyloid beta-protein in Alzheimer's disease brain.

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12 December 2020

Regional distribution of amyloid-Bri deposition and its association with neurofibrillary degeneration in familial British dementia

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12 December 2020

Regulation of amyloid precursor protein processing by presenilin 1 (PS1) and PS2 in PS1 knockout cells.

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12 December 2020

Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene

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12 December 2020

Beta APP mRNA transcription is increased in cultured fibroblasts from the familial Alzheimer's disease-1 family.

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12 December 2020

Neuronal apoptosis by apolipoprotein E4 through low-density lipoprotein receptor-related protein and heterotrimeric GTPases.

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12 December 2020

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

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12 December 2020

Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells

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12 December 2020

Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme

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12 December 2020

Soluble derivatives of the beta amyloid protein precursor of Alzheimer's disease are labeled by antisera to the beta amyloid protein.

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12 December 2020

Cholesterol-dependent formation of GM1 ganglioside-bound amyloid beta-protein, an endogenous seed for Alzheimer amyloid

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12 December 2020

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

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12 December 2020

Secretion of the beta/A4 amyloid precursor protein. Identification of a cleavage site in cultured mammalian cells

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12 December 2020

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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12 December 2020

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

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12 December 2020

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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12 December 2020

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

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12 December 2020

The transcriptional factor LBP-1c/CP2/LSF gene on chromosome 12 is a genetic determinant of Alzheimer's disease.

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12 December 2020

A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease

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12 December 2020

Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner

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12 December 2020

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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12 December 2020

APP gene family. Alternative splicing generates functionally related isoforms.

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12 December 2020

Functions of WW domains in the nucleus

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12 December 2020

The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids

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12 December 2020

PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein

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12 December 2020

Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

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12 December 2020

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

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12 December 2020

Cholinergic denervation and sympathetic ingrowth result in persistent changes in hippocampal muscarinic receptors.

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12 December 2020

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha

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12 December 2020

Characterization of high-affinity binding between gangliosides and amyloid beta-protein

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12 December 2020

Molecular determinants of amyloid deposition in Alzheimer's disease: conformational studies of synthetic beta-protein fragments.

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12 December 2020

Beta-amyloid precursor protein cleavage by a membrane-bound protease

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12 December 2020

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

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12 December 2020

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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12 December 2020

Proteolysis of Alzheimer's disease beta-amyloid precursor protein by factor Xa.

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12 December 2020

Characterization of an amyloid beta precursor protein that binds heparin and contains tyrosine sulfate

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12 December 2020

Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid beta42 in transfected cells.

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12 December 2020

Functional identification of the promoter of the gene encoding the Rhesus monkey β-amyloid precursor protein

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12 December 2020

Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein

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12 December 2020

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

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12 December 2020

The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion

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12 December 2020

The amyloid deposits in Alzheimer's disease: their nature and pathogenesis

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12 December 2020

The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system

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12 December 2020

Proprotein convertase activity contributes to the processing of the Alzheimer's beta-amyloid precursor protein in human cells: evidence for a role of the prohormone convertase PC7 in the constitutive alpha-secretase pathway

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12 December 2020

Processing of beta-secretase by furin and other members of the proprotein convertase family

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12 December 2020

Cholinesterase inhibitors, beta-amyloid precursor protein and amyloid beta-peptides in Alzheimer's disease.

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12 December 2020

GPI-anchored proteins and detergent-resistant membrane domains

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12 December 2020

Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related

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12 December 2020

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

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12 December 2020

apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor

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12 December 2020

Amyloid plaque core protein in Alzheimer disease and Down syndrome

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12 December 2020

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

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12 December 2020

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

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12 December 2020

The genetic defect causing familial Alzheimer's disease maps on chromosome 21.

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12 December 2020

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease

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12 December 2020

Selective ectodomain phosphorylation and regulated cleavage of beta-amyloid precursor protein

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12 December 2020

Serine phosphorylation of the secreted extracellular domain of APP.

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12 December 2020

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

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12 December 2020

The cholinergic hypothesis of geriatric memory dysfunction

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12 December 2020

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

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12 December 2020

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

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12 December 2020

Processing of the beta-amyloid precursor protein and its regulation in Alzheimer's disease

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12 December 2020

Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide

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12 December 2020

Role of endoplasmic reticulum, endosomal-lysosomal compartments, and microtubules in amyloid precursor protein metabolism of human neurons

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12 December 2020

Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype

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12 December 2020

Cleavage of amyloid beta peptide during constitutive processing of its precursor

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12 December 2020

A rat brain mRNA encoding a transcriptional activator homologous to the DNA binding domain of retroviral integrases

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12 December 2020

c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK

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12 December 2020

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

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12 December 2020

Regulation by phorbol esters of amyloid precursor protein release from Swiss 3T3 fibroblasts overexpressing protein kinase C alpha.

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12 December 2020

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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12 December 2020

A detergent-insoluble membrane compartment contains A beta in vivo.

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12 December 2020

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

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12 December 2020

The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain

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12 December 2020

The genetics of late-onset Alzheimer's disease.

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12 December 2020

Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease

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12 December 2020

Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF.

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12 December 2020

Interaction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's beta-amyloid precursor proteins

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12 December 2020

A stop-codon mutation in the BRI gene associated with familial British dementia

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12 December 2020

Cellular signaling roles of TGF beta, TNF alpha and beta APP in brain injury responses and Alzheimer's disease

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12 December 2020

Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor

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12 December 2020

The Drosophila transcript encoded by the beta-amyloid protein precursor-like gene is restricted to the nervous system.

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12 December 2020

Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex

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12 December 2020

Caveolae, transmembrane signalling and cellular transformation

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12 December 2020

Identification, secretion, and neural expression of APPL, a Drosophila protein similar to human amyloid protein precursor.

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12 December 2020

The role of A beta 42 in Alzheimer's disease

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12 December 2020

Promoter activity of the gene encoding the beta-amyloid precursor protein is up-regulated by growth factors, phorbol ester, retinoic acid and interleukin-1.

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12 December 2020

Phorbol ester stimulates choline uptake in Swiss 3T3 fibroblasts following introduction of the gene encoding protein kinase C alpha

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12 December 2020

Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells

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12 December 2020

The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled

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12 December 2020

Shared functions in vivo of a glycosyl-phosphatidylinositol-linked aspartyl protease, Mkc7, and the proprotein processing protease Kex2 in yeast

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12 December 2020

The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

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12 December 2020

Structural features and biochemical properties of TNF-alpha converting enzyme (TACE).

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12 December 2020

Pathogenesis of amyloid formation in Alzheimer's disease, Down's syndrome and scrapie

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12 December 2020

Genetic classification of primary neurodegenerative disease.

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12 December 2020

Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-alpha converting enzyme

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12 December 2020

The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1

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12 December 2020

βA4 amyloid protein deposition in brain after head trauma

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12 December 2020

Alpha-2 macroglobulin is genetically associated with Alzheimer disease.

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12 December 2020

Regulation of amyloid precursor protein cleavage.

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12 December 2020

Filamentous aggregates in Pick's disease, progressive supranuclear palsy, and Alzheimer's disease share antigenic determinants with microtubule-associated protein, tau.

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12 December 2020

Inflammation and Alzheimer's disease

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12 December 2020

Cell-free assays for gamma-secretase activity

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12 December 2020

Distinct secretases, a cysteine protease and a serine protease, generate the C termini of amyloid beta-proteins Abeta1-40 and Abeta1-42, respectively

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12 December 2020

A monoclonal antibody to amyloid precursor protein induces neuronal apoptosis

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12 December 2020

Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer's disease brains

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12 December 2020

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

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12 December 2020

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

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12 December 2020

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

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12 December 2020

The pathogenesis of Alzheimer disease: an alternative to the amyloid hypothesis

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12 December 2020

Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme

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12 December 2020

Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor

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12 December 2020

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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12 December 2020

Apolipoprotein E, plaques, tangles and cholinergic dysfunction in Alzheimer's disease.

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12 December 2020

Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease.

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12 December 2020

The Presence of Amyloid β-Protein in the Detergent-Insoluble Membrane Compartment of Human Neuroblastoma Cells†

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12 December 2020

Alpha 1-antichymotrypsin inhibits A beta degradation in vitro and in vivo.

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12 December 2020

The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

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12 December 2020

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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12 December 2020

Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice

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12 December 2020

Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor

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12 December 2020

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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12 December 2020

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

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12 December 2020

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

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12 December 2020

A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

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12 December 2020

One of the antigenic determinants of paired helical filaments is related to tau protein.

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12 December 2020

The Drosophila beta-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction.

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12 December 2020

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

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12 December 2020

The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

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12 December 2020

Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

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12 December 2020

G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP.

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12 December 2020

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

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12 December 2020

Cholinergic foundations of Alzheimer's disease therapy

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12 December 2020

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

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12 December 2020

Alzheimer's disease: genes, proteins, and therapy

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12 December 2020

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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12 December 2020

Metabolic regulation of brain Abeta by neprilysin.

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12 December 2020

Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis

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12 December 2020

Ligand-dependent G protein coupling function of amyloid transmembrane precursor

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12 December 2020

Tacrine alters the secretion of the beta-amyloid precursor protein in cell lines

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12 December 2020

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

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12 December 2020

Soluble Alzheimers beta-amyloid constricts the cerebral vasculature in vivo.

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12 December 2020

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

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12 December 2020

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o)

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12 December 2020

The Alzheimer beta-amyloid protein precursor/protease nexin-II is cleaved by secretase in a trans-Golgi secretory compartment in human neuroglioma cells

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12 December 2020

Observations on the brains of demented old people. B.E. Tomlinson, G. Blessed and M. Roth, Journal of the Neurological Sciences (1970) 11, 205-242 and Observations on the brains of non-demented old people. B.E. Tomlinson, G. Blessed and M. Roth, Jou

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12 December 2020

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

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12 December 2020

Amyloid precursor protein, although partially detergent-insoluble in mouse cerebral cortex, behaves as an atypical lipid raft protein

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12 December 2020

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

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12 December 2020

The secretion of amyloid beta-peptides is inhibited in the tacrine-treated human neuroblastoma cells.

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12 December 2020

Full-length and truncated Alzheimer amyloid precursors in chromaffin granules: solubilization of membrane amyloid precursor is mediated by an enzymatic mechanism.

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12 December 2020

Mutant presenilin 1 increases the levels of Alzheimer amyloid beta-peptide Abeta42 in late compartments of the constitutive secretory pathway.

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12 December 2020

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

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12 December 2020

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

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12 December 2020

Convertases other than furin cleave beta-secretase to its mature form.

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12 December 2020

Appican expression induces morphological changes in C6 glioma cells and promotes adhesion of neural cells to the extracellular matrix.

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12 December 2020

Heparin promotes beta-secretase cleavage of the Alzheimer's amyloid precursor protein

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12 December 2020

Transbilayer distribution of cholesterol is modified in brain synaptic plasma membranes of knockout mice deficient in the low-density lipoprotein receptor, apolipoprotein E, or both proteins.

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12 December 2020

Tau antisera recognize neurofibrillary tangles in a range of neurodegenerative disorders.

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12 December 2020

Estrogen attenuates cell death induced by carboxy-terminal fragment of amyloid precursor protein in PC12 through a receptor-dependent pathway

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12 December 2020

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

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12 December 2020

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

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12 December 2020

APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein

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12 December 2020

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

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12 December 2020

Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein.

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12 December 2020

Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid

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12 December 2020

Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease.

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12 December 2020

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

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12 December 2020

The molecular pathology of Alzheimer's disease

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12 December 2020

Expression of beta-amyloid precursor protein in reactive astrocytes following neuronal damage

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12 December 2020

The beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocation

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12 December 2020

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

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12 December 2020

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

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12 December 2020

Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site

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12 December 2020

Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein

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12 December 2020

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

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12 December 2020

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

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12 December 2020

Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice

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12 December 2020

Factors influencing the processing and function of the amyloid beta precursor protein--a potential therapeutic target in Alzheimer's disease?

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12 December 2020

Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations

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12 December 2020

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

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12 December 2020

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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12 December 2020

Intrinsic signaling function of APP as a novel target of three V642 mutations linked to familial Alzheimer's disease.

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12 December 2020

Processing of the notch ligand delta by the metalloprotease Kuzbanian

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12 December 2020

The role of cholesterol in the biosynthesis of beta-amyloid

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12 December 2020

hFE65L influences amyloid precursor protein maturation and secretion

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12 December 2020

Caveolin-3 upregulation activates beta-secretase-mediated cleavage of the amyloid precursor protein in Alzheimer's disease.

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12 December 2020

The chondroitin sulfate attachment site of appican is formed by splicing out exon 15 of the amyloid precursor gene

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12 December 2020

A 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell adhesion

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12 December 2020

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

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12 December 2020

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

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12 December 2020

Isolation of the genomic clone of the rhesus monkey beta-amyloid precursor protein

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12 December 2020

Alzheimer paired helical filaments: identification of polypeptides with monoclonal antibodies.

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12 December 2020

Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics

1 reference

12 December 2020

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

1 reference

12 December 2020

Identification of heparin-binding domains in the amyloid precursor protein of Alzheimer's disease by deletion mutagenesis and peptide mapping.

1 reference

12 December 2020

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides

1 reference

12 December 2020

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

1 reference

12 December 2020

The promoter activity of the gene encoding Alzheimer β-amyloid precursor protein (APP) is regulated by two blocks of upstream sequences

1 reference

12 December 2020

Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein

1 reference

12 December 2020

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

1 reference

12 December 2020

Quantification of APP and APLP2 mRNA in APOE genotyped Alzheimer's disease brains.

1 reference

12 December 2020

Inhibition of beta-amyloid production by activation of protein kinase C.

1 reference

12 December 2020

Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein

1 reference

12 December 2020

Molecular cloning of the promoter of the gene encoding the Rhesus monkey beta-amyloid precursor protein: structural characterization and a comparative study with other species.

1 reference

12 December 2020

Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17

1 reference

12 December 2020

Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides

1 reference

12 December 2020

Chromosome 21q21 sublocalisation of gene encoding beta-amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer disease and Down syndrome

1 reference

12 December 2020

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

1 reference

12 December 2020

Increased production of 4 kDa amyloid beta peptide in serum deprived human primary neuron cultures: possible involvement of apoptosis

1 reference

12 December 2020

Rapid stimulation of amyloid precursor protein release by epidermal growth factor: role of protein kinase C.

1 reference

12 December 2020

Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells.

1 reference

12 December 2020

Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing

1 reference

12 December 2020

Regulation of the neural-specific gene VGF in PC12 cells. Identification of transcription factors interacting with NGF-responsive elements

1 reference

12 December 2020

Estrogen stakes claim to cognition.

1 reference

12 December 2020

A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.

1 reference

12 December 2020

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

1 reference

12 December 2020

Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein

1 reference

12 December 2020

Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport.

1 reference

12 December 2020

The amyloid precursor protein interacts with Go heterotrimeric protein within a cell compartment specialized in signal transduction

1 reference

12 December 2020

Presenilin and gamma-secretase: structure meets function

1 reference

12 December 2020

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

12 December 2020

Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin

1 reference

12 December 2020

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

1 reference

12 December 2020

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

12 December 2020

Cellular mechanisms of beta-amyloid production and secretion

1 reference

12 December 2020

Platelet coagulation factor XIa-inhibitor, a form of Alzheimer amyloid precursor protein

1 reference

12 December 2020

Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42

1 reference

12 December 2020

Observations in a preliminary open trial of estradiol therapy for senile dementia-Alzheimer's type.

1 reference

12 December 2020

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation

1 reference

12 December 2020

The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities

1 reference

12 December 2020

A fluid connection: cholesterol and Abeta

1 reference

12 December 2020

Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences.

1 reference

12 December 2020

Tau is a candidate gene for chromosome 17 frontotemporal dementia

1 reference

12 December 2020

Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide.

1 reference

12 December 2020

Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

1 reference

12 December 2020

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.

1 reference

12 December 2020

Vasopressin and bradykinin regulate secretory processing of the amyloid protein precursor of Alzheimer's disease

1 reference

12 December 2020

A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor

1 reference

12 December 2020

Mint 3: a ubiquitous mint isoform that does not bind to munc18-1 or -2

1 reference

12 December 2020

Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1

1 reference

12 December 2020

The plasmin system is induced by and degrades amyloid-beta aggregates

1 reference

12 December 2020

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

1 reference

12 December 2020

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

12 December 2020

Plasmin cleavage of the amyloid beta-protein: alteration of secondary structure and stimulation of tissue plasminogen activator activity

1 reference

12 December 2020

Constitutive alpha-secretase cleavage of the beta-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10.

1 reference

12 December 2020

Nerve growth factor induces transcription of transforming growth factor-beta 1 through a specific promoter element in PC12 cells

1 reference

12 December 2020

Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filaments

1 reference

12 December 2020

The phosphatidylinositol 3-kinase inhibitor wortmannin alters the metabolism of the Alzheimer's amyloid precursor protein.

1 reference

12 December 2020

Relation of neuronal APP-751/APP-695 mRNA ratio and neuritic plaque density in Alzheimer's disease

1 reference

12 December 2020

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

12 December 2020

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

12 December 2020

Proteolytic processing and cell biological functions of the amyloid precursor protein

1 reference

12 December 2020

Identifiers

DOI

10.1385/NMM:1:1:1

1 reference

Dimensions Publication ID

3 August 2017

0 references

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