MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae (Q27934823)

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English	MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae	scientific article

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scholarly article

1 reference

Europe PubMed Central

4 July 2017

MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae (English)

1 reference

Europe PubMed Central

4 July 2017

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Saccharomyces cerevisiae

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1 reference

GOA release 2020-03-11

3

1 reference

Europe PubMed Central

4 July 2017

author name string

Shinichiro Enomoto

1

1 reference

Europe PubMed Central

4 July 2017

Lynn Glowczewski

2

1 reference

Europe PubMed Central

4 July 2017

language of work or name

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publication date

1 August 2002

1 reference

Europe PubMed Central

4 July 2017

Molecular Biology of the Cell

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Europe PubMed Central

4 July 2017

13

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Europe PubMed Central

4 July 2017

8

1 reference

Europe PubMed Central

4 July 2017

2626-2638

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Europe PubMed Central

4 July 2017

Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

20 March 2017

Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

20 March 2017

LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

20 March 2017

The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

20 March 2017

Involvement of the checkpoint protein Mec1p in silencing of gene expression at telomeres in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

20 March 2017

A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

20 March 2017

Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

20 March 2017

Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

20 March 2017

The selection of S. cerevisiae mutants defective in the start event of cell division

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

20 March 2017

A mutant with a defect in telomere elongation leads to senescence in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

20 March 2017

A family of cyclin homologs that control the G1 phase in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

20 March 2017

Getting started with yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

20 March 2017

The DNA damage response: putting checkpoints in perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

20 March 2017

Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

20 March 2017

The yeast Xrs2 complex functions in S phase checkpoint regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

20 March 2017

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

20 March 2017

Switching and signaling at the telomere

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

7 April 2017

Telomerase catalytic subunit homologs from fission yeast and human

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

7 April 2017

An alternative pathway for yeast telomere maintenance rescues est1- senescence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

7 April 2017

TLC1: template RNA component of Saccharomyces cerevisiae telomerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

7 April 2017

The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

7 April 2017

An essential G1 function for cyclin-like proteins in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

7 April 2017

Two checkpoint complexes are independently recruited to sites of DNA damage in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

29 September 2017

Turning telomeres off and on.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

29 September 2017

Pie1, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

29 September 2017

The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

29 September 2017

Varying the number of telomere-bound proteins does not alter telomere length in tel1Delta cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

29 September 2017

Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

29 September 2017

Dependence of the regulation of telomere length on the type of subtelomeric repeat in the yeast Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

29 September 2017

RAD53, DUN1 and PDS1 define two parallel G2/M checkpoint pathways in budding yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

29 September 2017

RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

29 September 2017

Uncapping and deregulation of telomeres lead to detrimental cellular consequences in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

29 September 2017

Critical telomere shortening regulated by the ataxia-telangiectasia gene acts as a DNA damage signal leading to activation of p53 protein and limited life-span of human diploid fibroblasts. A review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

29 September 2017

Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

29 September 2017

Origin activation and formation of single-strand TG1-3 tails occur sequentially in late S phase on a yeast linear plasmid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

29 September 2017

Dual cell cycle checkpoints sensitive to chromosome replication and DNA damage in the budding yeast Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

29 September 2017

Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

2 June 2018

PAK-family kinases regulate cell and actin polarization throughout the cell cycle of Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

2 June 2018

Progressive cis-inhibition of telomerase upon telomere elongation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

2 June 2018

DNA damage checkpoint in budding yeast.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

2 June 2018

Altering telomere structure allows telomerase to act in yeast lacking ATM kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

27 November 2018

Telomere states and cell fates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

27 November 2018

Circular chromosome formation in a fission yeast mutant defective in two ATM homologues.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

27 November 2018

Block in anaphase chromosome separation caused by a telomerase template mutation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

27 November 2018

Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=117930

27 November 2018

Micromanipulation and dissection of asci

1 reference

https://pubmed.ncbi.nlm.nih.gov/12181334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12181334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of a yeast telomere: arrest, recovery, and chromosome loss.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12181334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in SPK1/RAD53 that specifically abolish checkpoint but not growth-related functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/12181334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of calcineurin and Mpk1 in regulating the onset of mitosis in budding yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/12181334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process

1 reference

https://pubmed.ncbi.nlm.nih.gov/12181334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A DNA damage response pathway controlled by Tel1 and the Mre11 complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/12181334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of the Mre11-Rad50-Xrs2 complex in telomerase- mediated lengthening of Saccharomyces cerevisiae telomeres

1 reference

https://pubmed.ncbi.nlm.nih.gov/12181334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exonuclease activity is required for sequence addition and Cdc13p loading at a de novo telomere

1 reference

https://pubmed.ncbi.nlm.nih.gov/12181334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

1 reference

https://pubmed.ncbi.nlm.nih.gov/12181334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/12181334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical significance of telomerase activation and telomeric restriction fragment (TRF) in cervical cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/12181334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1091/MBC.02-02-0012

1 reference

Europe PubMed Central

4 July 2017

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1 reference

Europe PubMed Central

4 July 2017

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