ADAM metallopeptidase with thrombospondin type 1 motif 13 (Q4651006)

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mammalian protein found in Homo sapiens

a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13
vWF-cleaving protease
ADAMTS13
A disintegrin and metalloproteinase with thrombospondin motifs 13
vWF-CP
von Willebrand factor-cleaving protease

Language	Label	Description	Also known as
English	ADAM metallopeptidase with thrombospondin type 1 motif 13	mammalian protein found in Homo sapiens	a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13 vWF-cleaving protease ADAMTS13 A disintegrin and metalloproteinase with thrombospondin motifs 13 vWF-CP von Willebrand factor-cleaving protease

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

calcium ion binding

determination method

1 reference

8 April 2019

Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

endopeptidase activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

integrin binding

determination method

1 reference

8 April 2019

Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

protein binding

determination method

4 references

8 April 2019

ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

8 April 2019

Allosteric activation of ADAMTS13 by von Willebrand factor.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

8 April 2019

ADAMTS13 substrate recognition of von Willebrand factor A2 domain

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

8 April 2019

Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

metalloendopeptidase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

metallopeptidase activity

determination method

3 references

8 April 2019

Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

zinc ion binding

determination method

1 reference

8 April 2019

Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

endoplasmic reticulum lumen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

extracellular region

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

determination method

1 reference

8 April 2019

Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

extracellular space

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

extracellular matrix

determination method

1 reference

8 April 2019

Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

biological process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

glycoprotein metabolic process

determination method

1 reference

8 April 2019

Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

response to interleukin-4

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

response to interferon-gamma

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

protein processing

determination method

1 reference

8 April 2019

Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

blood coagulation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

8 April 2019

Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

platelet activation

determination method

1 reference

8 April 2019

Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

response to tumor necrosis factor

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

integrin-mediated signaling pathway

determination method

1 reference

8 April 2019

Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

cell-matrix adhesion

determination method

1 reference

8 April 2019

Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

response to toxic substance

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

peptide catabolic process

determination method

1 reference

8 April 2019

Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

response to potassium ion

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

cellular response to interferon-gamma

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

cellular response to lipopolysaccharide

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

response to amine

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

cellular response to interleukin-4

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

cellular response to tumor necrosis factor

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q76LX8

determination method

Gene Atlas image

PBB GE ADAMTS13 220208 at fs.png
732 × 530; 11 KB

0 references

Identifiers

MeSH descriptor ID

subject named as

ADAMTS13 Protein

0 references

D08.811.277.656.675.374.102.500.813

0 references

D09.400.430.500.500.813

0 references

D12.776.395.033.500.813

0 references

D12.776.860.300.085.813

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000347927

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000347927

ENSP00000348997

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000348997

ENSP00000360997

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000360997

ENSP00000486201

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486201

ENSP00000486734

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486734

ENSP00000485989

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000485989

ENSP00000360979

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000360979

ENSP00000435274

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000435274

ENSP00000360984

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000360984

ENSP00000485845

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000485845

ENSP00000487185

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000487185

ENSP00000487509

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000487509

ENSP00000360978

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000360978

ENSP00000486060

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486060

ENSP00000435305

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000435305

ENSP00000486371

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486371

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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