Safinamide and flecainide protect axons and reduce microglial activation in models of multiple sclerosis. (Q46490485)

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26 February 2020

title

Safinamide and flecainide protect axons and reduce microglial activation in models of multiple sclerosis (English)

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26 February 2020

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2

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26 February 2020

Thomas M Piers

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26 February 2020

Jennifer Pocock

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26 February 2020

Kenneth J Smith

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26 February 2020

author name string

Damineh Morsali

1

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26 February 2020

Woojin Lee

3

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26 February 2020

Summen Chauhdry

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26 February 2020

Upayan Palchaudhuri

5

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26 February 2020

Paula Hassoon

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26 February 2020

Daniel M Snell

7

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26 February 2020

Katy Malpass

8

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26 February 2020

Arthur Roach

11

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26 February 2020

language of work or name

English

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publication date

20 March 2013

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26 February 2020

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26 February 2020

volume

136

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26 February 2020

issue

Pt 4

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26 February 2020

page(s)

1067-1082

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Induction of neonatal sodium channel II and III alpha-isoform mRNAs in neurons and microglia after status epilepticus in the rat hippocampus.

26 February 2020

cites work

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Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion

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Axonal protection using flecainide in experimental autoimmune encephalomyelitis.

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Sodium-mediated axonal degeneration in inflammatory demyelinating disease.

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Axonal protection in experimental autoimmune neuritis by the sodium channel blocking agent flecainide.

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Sodium channel activity modulates multiple functions in microglia

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Sodium channels and microglial function

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Uncoupling cell shrinkage from apoptosis reveals that Na+ influx is required for volume loss during programmed cell death

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Safinamide: from molecular targets to a new anti-Parkinson drug

21 January 2018

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Potent blockade of sodium channels and protection of brain tissue from ischemia by BIII 890 CL.

21 January 2018

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Sodium channels contribute to microglia/macrophage activation and function in EAE and MS.

21 January 2018

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Voltage-dependent ion channels in T-lymphocytes

21 January 2018

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Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis

21 January 2018

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Antioxidant and bioenergetic coupling between neurons and astrocytes.

21 January 2018

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Interferon-beta-1b slows progression of atrophy in RRMS: Three-year follow-up in NAb- and NAb+ patients.

21 January 2018

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The relation between inflammation and neurodegeneration in multiple sclerosis brains.

21 January 2018

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Retrograde perfusion with a sodium channel antagonist provides ischemic spinal cord protection

21 January 2018

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Neurofilament a biomarker of neurodegeneration in autoimmune encephalomyelitis

21 January 2018

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Oxidative damage in multiple sclerosis lesions

21 January 2018

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Rate of brain atrophy in relapsing MS decreases during treatment with IFNbeta-1a.

21 January 2018

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Scavenger receptor control of chromogranin A-induced microglial stress and neurotoxic cascades.

21 January 2018

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Blockers of sodium and calcium entry protect axons from nitric oxide-mediated degeneration

21 January 2018

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Lamotrigine for neuroprotection in secondary progressive multiple sclerosis: a randomised, double-blind, placebo-controlled, parallel-group trial.

21 January 2018

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Quantitative imaging of glutathione in hippocampal neurons and glia in culture using monochlorobimane

21 January 2018

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Voltage-gated currents expressed by rat microglia in culture

21 January 2018

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Neuroprotection of axons with phenytoin in experimental allergic encephalomyelitis

21 January 2018

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Phenytoin protects spinal cord axons and preserves axonal conduction and neurological function in a model of neuroinflammation in vivo

21 January 2018

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Lesion genesis in a subset of patients with multiple sclerosis: a role for innate immunity?

21 January 2018

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Microglial neurotransmitter receptors trigger superoxide production in microglia; consequences for microglial-neuronal interactions

21 January 2018

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MRI outcomes in a placebo-controlled trial of natalizumab in relapsing MS.

21 January 2018

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The MAO inhibitor phenelzine improves functional outcomes in mice with experimental autoimmune encephalomyelitis (EAE).

21 January 2018

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Na(v)1.5 sodium channels in a human microglial cell line.

21 January 2018

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21 January 2018

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Safinamide in the treatment of Parkinson's disease

21 January 2018

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Inflammation induced by innate immunity in the central nervous system leads to primary astrocyte dysfunction followed by demyelination.

21 January 2018

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Newly lesioned tissue in multiple sclerosis--a role for oxidative damage?

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General mechanisms of axonal damage and its prevention

21 January 2018

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Clinico-pathological evidence that axonal loss underlies disability in progressive multiple sclerosis

21 January 2018

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Pathogenesis of tissue injury in MS lesions

21 January 2018

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21 January 2018

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The anticonvulsive drug lamotrigine blocks neuronal {alpha}4{beta}2 nicotinic acetylcholine receptors.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/BRAIN/AWT041

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23518709%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

1 reference

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