Activation of protease-activated receptor-1 triggers astrogliosis after brain injury. (Q46461044)

http://europepmc.org/abstract/MED/15858058

22 December 2017

title

Activation of protease-activated receptor-1 triggers astrogliosis after brain injury (English)

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12 May 2020

1

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12 May 2020

author name string

Anna Goldshmidt

2

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12 May 2020

Cecily E Hamill

3

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12 May 2020

Scott D Sorensen

4

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12 May 2020

Aristide Sastre

5

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12 May 2020

Polina Lyuboslavsky

6

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12 May 2020

John R Hepler

7

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12 May 2020

Robert J McKeon

8

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12 May 2020

Stephen F Traynelis

9

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12 May 2020

language of work or name

English

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publication date

1 April 2005

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http://europepmc.org/abstract/MED/15858058

22 December 2017

published in

Journal of Neuroscience

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12 May 2020

volume

25

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12 May 2020

issue

17

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12 May 2020

page(s)

4319-4329

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Evolving ideas about cyclins

12 May 2020

cites work

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12 December 2020

The glial scar and central nervous system repair

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12 December 2020

Regulation of p21(cip1) expression by growth factors and the extracellular matrix reveals a role for transient ERK activity in G1 phase

1 reference

12 December 2020

Alpha5beta1 integrin controls cyclin D1 expression by sustaining mitogen-activated protein kinase activity in growth factor-treated cells

1 reference

12 December 2020

Activation of microglia reveals a non-proteolytic cytokine function for tissue plasminogen activator in the central nervous system

1 reference

12 December 2020

The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations

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12 December 2020

Differential regulation of cyclin D1 and D3 expression in the control of astrocyte proliferation induced by endothelin-1

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12 December 2020

Glial cell proliferation in the spinal cord after dorsal rhizotomy or sciatic nerve transection in the adult rat

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12 December 2020

Serine protease inhibitors: novel therapeutic targets for stroke?

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12 December 2020

Potentiation of NMDA receptor function by the serine protease thrombin

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12 December 2020

Thrombin induces NO release from cultured rat microglia via protein kinase C, mitogen-activated protein kinase, and NF-kappa B

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12 December 2020

Ischemia-Induced Interleukin-6 as a Potential Endogenous Neuroprotective Cytokine against NMDA Receptor-Mediated Excitoxicity in the Brain

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12 December 2020

Serine proteases and brain damage - is there a link?

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12 December 2020

Integrating the MAP kinase signal into the G1 phase cell cycle machinery

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12 December 2020

Motor neuron cell death in wobbler mutant mice follows overexpression of the G-protein-coupled, protease-activated receptor for thrombin

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12 December 2020

Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke.

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12 December 2020

Proteinase-activated receptors.

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12 December 2020

p27Kip1 and p57Kip2 regulate proliferation in distinct retinal progenitor cell populations.

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12 December 2020

Thrombin and PAR-1 activating peptide increase iNOS expression in cytokine-stimulated C6 glioma cells

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12 December 2020

Requirement of functional ryanodine receptor type 3 for astrocyte migration.

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12 December 2020

Timing of cyclin D1 expression within G1 phase is controlled by Rho.

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12 December 2020

Four subtypes of protease-activated receptors, co-expressed in rat astrocytes, evoke different physiological signaling

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12 December 2020

Participation of protease-activated receptor-1 in thrombin-induced microglial activation

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12 December 2020

Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways

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12 December 2020

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

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12 December 2020

PAR1 signaling: more good than harm?

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12 December 2020

Protease-activated receptors: a means of converting extracellular proteolysis into intracellular signals.

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12 December 2020

Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor

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12 December 2020

Persistent protease-activated receptor 4 signaling mediates thrombin-induced microglial activation

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12 December 2020

Axonal plasticity and functional recovery after spinal cord injury in mice deficient in both glial fibrillary acidic protein and vimentin genes

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12 December 2020

Transient neuronal but persistent astroglial activation of ERK/MAP kinase after focal brain injury in mice

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12 December 2020

The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia

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12 December 2020

Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes.

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12 December 2020

Regeneration beyond the glial scar

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12 December 2020

Thrombin preconditioning upregulates transferrin and transferrin receptor and reduces brain edema induced by lysed red blood cells

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12 December 2020

Thrombin accumulation in brains of patients with Alzheimer's disease

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12 December 2020

Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3

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12 December 2020

Pro-regenerative properties of cytokine-activated astrocytes.

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12 December 2020

Protease-activated receptor-1 in human brain: localization and functional expression in astrocytes

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12 December 2020

PAR-1 deficiency protects against neuronal damage and neurologic deficits after unilateral cerebral hypoxia/ischemia

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12 December 2020

Protease nexin I, thrombin- and urokinase-inhibiting serpin, concentrated in normal human cerebrospinal fluid

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12 December 2020

Thrombin activity in cerebrospinal fluid after subarachnoid hemorrhage

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12 December 2020

Single amino acid substitutions dissociate fibrinogen-clotting and thrombomodulin-binding activities of human thrombin

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12 December 2020

cDNA cloning and expression of a hamster alpha-thrombin receptor coupled to Ca2+ mobilization.

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12 December 2020

Special lecture: glial reactivity after damage: implications for scar formation and neuronal recovery.

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12 December 2020

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

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12 December 2020

Astroglia in CNS injury

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12 December 2020

Prothrombin mRNA is expressed by cells of the nervous system.

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12 December 2020

An in vitro model of wound healing in the CNS: analysis of cell reaction and interaction at different ages

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12 December 2020

Astrocyte overgrowth in the brain stem and spinal cord of mice affected by spinal atrophy, wobbler

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12 December 2020

Thrombin active-site regions

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12 December 2020

Thrombin is a regulator of astrocytic endothelin-1.

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12 December 2020

Thrombin may contribute to the pathophysiology of central nervous system injury.

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12 December 2020

Cellular localization of thrombin receptor mRNA in rat brain: expression by mesencephalic dopaminergic neurons and codistribution with prothrombin mRNA.

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12 December 2020

Astrogliosis in culture. IV. Effects of basic fibroblast growth factor

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12 December 2020

Thrombin receptor activation stimulates astrocyte proliferation and reversal of stellation by distinct pathways: involvement of tyrosine phosphorylation

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12 December 2020

Abnormal astrocyte differentiation and defective cellular interactions in wobbler mouse spinal cord.

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12 December 2020

Thrombin receptor peptides induce shape change in neonatal murine astrocytes in culture.

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12 December 2020

Glial-specific cAMP response of the glial fibrillary acidic protein gene cell lines

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12 December 2020

Protease nexin-1 and thrombin: injury-related processes in the brain

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12 December 2020

Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development

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12 December 2020

Enhancement of the synthesis and secretion of nerve growth factor in primary cultures of glial cells by proteases: a possible involvement of thrombin.

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12 December 2020

Cellular consequences of thrombin-receptor activation

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12 December 2020

Edema from intracerebral hemorrhage: the role of thrombin

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12 December 2020

Transduction mechanisms involved in thrombin receptor-induced nerve growth factor secretion and cell division in primary cultures of astrocytes

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12 December 2020

Role of the thrombin receptor in development and evidence for a second receptor.

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12 December 2020

Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway.

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12 December 2020

Accumulation of the cyclin-dependent kinase inhibitor p27/Kip1 and the timing of oligodendrocyte differentiation

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12 December 2020

Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice.

1 reference

12 December 2020

Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides

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12 December 2020

Astrocyte spreading in response to thrombin and lysophosphatidic acid is dependent on the Rho GTPase

1 reference

12 December 2020

Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27

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12 December 2020

Reactive astrocytes: cellular and molecular cues to biological function

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12 December 2020

Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)

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12 December 2020

Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis

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12 December 2020

Signaling pathways involved in thrombin-induced cell protection

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12 December 2020

Thrombin-induced reversal of astrocyte stellation is mediated by activation of protein kinase C beta-1

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12 December 2020

Cyclin D3: requirement for G1/S transition and high abundance in quiescent tissues suggest a dual role in proliferation and differentiation

1 reference

12 December 2020

10.1523/JNEUROSCI.5200-04.2005

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725104&resulttype=core&format=json

12 May 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725104&resulttype=core&format=json

12 May 2020

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