Serine proteases and brain damage - is there a link? (Q30305943)

16 June 2017

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title

Serine proteases and brain damage - is there a link? (English)

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16 June 2017

Gingrich MB

1

1 reference

PubMed ID

10941185

16 June 2017

Traynelis SF

series ordinal

2

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16 June 2017

1 September 2000

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16 June 2017

Trends in Neurosciences

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16 June 2017

23

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16 June 2017

399-407

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16 June 2017

9

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Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

16 June 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Molecular cloning of a potential proteinase activated receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Protease-activated receptor 3 is a second thrombin receptor in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

A dual thrombin receptor system for platelet activation

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Cloning and characterization of human protease-activated receptor 4

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Gene and locus structure and chromosomal localization of the protease-activated receptor gene family

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Domains specifying thrombin–receptor interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Cellular consequences of thrombin-receptor activation

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Proteinase-activated receptors: novel mechanisms of signaling by serine proteases.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Plasmin Desensitization of the PAR1 Thrombin Receptor: Kinetics, Sites of Truncation, and Implications for Thrombolytic Therapy†

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Thrombin receptor on rat primary hippocampal neurons: coupled calcium and cAMP responses

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Potentiation of NMDA receptor function by the serine protease thrombin

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Thrombin binding and stimulation of cyclic guanosine monophosphate formation in neuroblastoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

The role of thrombin-like (serine) proteases in the development, plasticity and pathology of the nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Protease-activated receptor-1 can mediate responses to SFLLRN in thrombin-desensitized cells: evidence for a novel mechanism for preventing or terminating signaling by PAR1's tethered ligand

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Cellular localization of thrombin receptor mRNA in rat brain: expression by mesencephalic dopaminergic neurons and codistribution with prothrombin mRNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Changes in the expression of protease-activated receptor 1 and protease nexin-1 mRNA during rat nervous system development and after nerve lesion

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Prothrombin mRNA is expressed by cells of the nervous system.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Mechanism of thrombin clearance by human astrocytoma cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Prevention of activity-dependent neuronal death: vasoactive intestinal polypeptide stimulates astrocytes to secrete the thrombin-inhibiting neurotrophic serpin, protease nexin I

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Protease nexin-1 and thrombin modulate neuronal Ca2+ homeostasis and sensitivity to glucose deprivation-induced injury

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

The prolonged presence of glia-derived nexin, an endogenous protease inhibitor, in the hippocampus after ischemia-induced delayed neuronal death

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Thrombin activity in cerebrospinal fluid after subarachnoid hemorrhage

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Edema from intracerebral hemorrhage: the role of thrombin

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Thrombin-soaked gelatin sponge and brain edema in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

tPA: a neuron buster, too?

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Thrombin modulates and reverses neuroblastoma neurite outgrowth

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Thrombin causes neurite retraction in neuronal cells through activation of cell surface receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Thrombin perturbs neurite outgrowth and induces apoptotic cell death in enriched chick spinal motoneuron cultures through caspase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Microglia-derived plasminogen enhances neurite outgrowth from explant cultures of rat brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Tissue plasminogen activator contributes to the late phase of LTP and to synaptic growth in the hippocampal mossy fiber pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Proteolytic action of thrombin is required for electrical activity-dependent synapse reduction

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Involvement of protease-activated receptor-1 in the in vitro development of mesencephalic dopaminergic neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Reciprocal Modulation of Astrocyte Stellation by Thrombin and Protease Nexin-1

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Transduction mechanisms involved in thrombin receptor-induced nerve growth factor secretion and cell division in primary cultures of astrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Thrombomodulin as a new marker of lesion-induced astrogliosis: involvement of thrombin through the G-protein-coupled protease-activated receptor-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Thrombin may contribute to the pathophysiology of central nervous system injury.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Hirudin suppresses the invasion of inflammatory cells and the appearance of vimentin-positive astrocytes in the rat cerebral ablation model.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Role of blood clot formation on early edema development after experimental intracerebral hemorrhage.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Plasminogen activators potentiate thrombin-induced brain injury.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Activation of the protease-activated thrombin receptor (PAR)-1 induces motoneuron degeneration in the developing avian embryo

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Post-traumatic epilepsy: cellular mechanisms and implications for treatment

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Early seizures after mild closed head injury

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

A population-based study of seizures after traumatic brain injuries

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Early seizures following intracerebral hemorrhage: Implications for therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Seizures after primary intracerebral hemorrhage

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Risk factors for developing seizures after a stroke.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Predictive factors of early seizures after acute cerebrovascular disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Seizures induced by intracerebral injection of thrombin: a model of intracerebral hemorrhage.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Chronic Focal Epileptiform Discharges Induced by Injection of Iron Into Rat and Cat Cortex

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Epilepsy and the too-well-connected brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Postsynaptic blockade of inhibitory postsynaptic currents by plasmin in CA1 pyramidal cells of rat hippocampus.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Endogenous serine protease inhibitor modulates epileptic activity and hippocampal long-term potentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Tissue-plasminogen activator is induced as an immediate-early gene during seizure, kindling and long-term potentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Role of Tissue Plasminogen Activator Receptor LRP in Hippocampal Long-Term Potentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Clinical implications of the involvement of tPA in neuronal cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Induction of plasminogen in rat hippocampal pyramidal neurons by kainic acid.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Nonproteolytic neuroprotection by human recombinant tissue plasminogen activator

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Matrix metalloproteinases in cerebrovascular disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Proteolysis of neuronal cell adhesion molecule by the tissue plasminogen activator-plasmin system after kainate injection in the mouse hippocampus.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Neuronal death and blood-brain barrier breakdown after excitotoxic injury are independent processes

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Systematic review of evidence on thrombolytic therapy for acute ischaemic stroke

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

Trends and future developments in the pharmacological treatment of acute ischaemic stroke

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901617-9

7 January 2021

10.1016/S0166-2236(00)01617-9

Identifiers

DOI

1 reference

16 June 2017

1 reference

PubMed ID

10941185