Fluoride complexes of oncogenic Ras mutants to study the Ras-RasGap interaction (Q46422384)

22 December 2017

title

Fluoride complexes of oncogenic Ras mutants to study the Ras-RasGap interaction (English)

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22 December 2017

author

Lothar Gremer

series ordinal

1

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22 December 2017

Alfred Wittinghofer

series ordinal

4

object named as

Alfred Wittinghofer

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22 December 2017

Bernd Gilsbach

2

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22 December 2017

Mohammad Reza Ahmadian

series ordinal

3

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22 December 2017

publication date

1 September 2008

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22 December 2017

published in

Biological Chemistry

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22 December 2017

volume

389

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22 December 2017

issue

9

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22 December 2017

page(s)

1163-1171

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22 December 2017

Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain

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1 reference

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Aluminum fluoride associates with the small guanine nucleotide binding proteins.

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Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2008.132

Guanosine triphosphatase stimulation of oncogenic Ras mutants

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2008.132

Ras catalyzes GTP hydrolysis by shifting negative charges from gamma- to beta-phosphate as revealed by time-resolved FTIR difference spectroscopy

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2008.132

The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2008.132

Proteins regulating Ras and its relatives

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2008.132

dbEST--database for "expressed sequence tags"

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2008.132

Differential regulation of rasGAP and neurofibromatosis gene product activities

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2008.132

Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

Structure of the carboxyl terminus of the RAS gene-encoded P21 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

Aluminofluoride and beryllofluoride complexes: a new phosphate analogs in enzymology

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP.BeFx and MgADP.AlF4-

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

Purification of ras GTPase activating protein from bovine brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

21 January 2018

Ras and its effectors

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

Regional polysterism in the GTP-bound form of the human c-Ha-Ras protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

A phosphoryl transfer intermediate in the GTPase reaction of Ras in complex with its GTPase-activating protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

Ras-catalyzed hydrolysis of GTP: a new perspective from model studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

Interactions between Ras proteins and their effectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

Ras/Rap effector specificity determined by charge reversal

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

Kinetics of inorganic phosphate release during the interaction of p21ras with the GTPase-activating proteins, p120-GAP and neurofibromin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

The Ras branch of small GTPases: Ras family members don't fall far from the tree

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

The P-loop--a common motif in ATP- and GTP-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

GTPase activating proteins: structural and functional insights 18 years after discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

Structural analysis of the GAP-related domain from neurofibromin and its implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

pH influences fluoride coordination number of the AlFx phosphoryl transfer transition state analog

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

GTP-binding proteins. Structures, interactions and relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

Biological properties of human c-Ha-ras1 genes mutated at codon 12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

Dynamic properties of the Ras switch I region and its importance for binding to effectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

Cloning of bovine GAP and its interaction with oncogenic ras p21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

Signaling pathways in Ras-mediated tumorigenicity and metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

Multiple Ras functions can contribute to mammalian cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

Signaling mechanistics: aluminum fluoride for molecule of the year

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

The structure of Ras protein: a model for a universal molecular switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

Ras-effector interactions, the problem of specificity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

AlF3 mimics the transition state of protein phosphorylation in the crystal structure of nucleoside diphosphate kinase and MgADP

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

Surface Change of Ras Enabling Effector Binding Monitored in Real Time at Atomic Resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.132

21 January 2018

Identifiers

DOI

10.1515/BC.2008.132

1 reference

22 December 2017

PubMed ID

18713003

1 reference

22 December 2017