The expression of phospho-AKT1 and phospho-MTOR is associated with a favorable prognosis independent of PTEN expression in intrahepatic cholangiocarcinomas. (Q46257880)

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English	The expression of phospho-AKT1 and phospho-MTOR is associated with a favorable prognosis independent of PTEN expression in intrahepatic cholangiocarcinomas.	scientific article

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11 February 2020

The expression of phospho-AKT1 and phospho-MTOR is associated with a favorable prognosis independent of PTEN expression in intrahepatic cholangiocarcinomas (English)

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11 February 2020

cholangiocarcinoma

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11 February 2020

author name string

Dakeun Lee

1

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11 February 2020

In-Gu Do

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11 February 2020

Kyusam Choi

3

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11 February 2020

Kee-Taek Jang

5

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11 February 2020

Dongwook Choi

6

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11 February 2020

Jin Seok Heo

7

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11 February 2020

Seoung Ho Choi

8

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11 February 2020

Jongmin Kim

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11 February 2020

Jin Young Park

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11 February 2020

Kwan Yong Choi

13

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Dae Shick Kim

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publication date

26 August 2011

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11 February 2020

Modern Pathology

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25

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1

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11 February 2020

131-139

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11 February 2020

https://scigraph.springernature.com/pub.10.1038/modpathol.2011.133

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Cholangiocarcinoma. A spectrum of intrahepatic, perihilar, and distal tumors

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https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States

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https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

Trends in the incidence of primary liver and biliary tract cancers in England and Wales 1971-2001

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21 January 2018

Surgical management of cholangiocarcinoma

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https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

Perturbations of the AKT signaling pathway in human cancer

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https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

Exploiting the PI3K/AKT pathway for cancer drug discovery

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https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

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21 January 2018

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

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https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

PI3K/PTEN signaling in tumorigenesis and angiogenesis

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21 January 2018

Tenets of PTEN tumor suppression

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21 January 2018

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

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https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome.

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https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

Upstream and downstream of mTOR

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https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

mTOR and cancer: insights into a complex relationship

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https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

Ras, PI(3)K and mTOR signalling controls tumour cell growth

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https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

eIF4E expression in tumors: its possible role in progression of malignancies

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https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

Targeting the mTOR signaling network in cancer.

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

Activated mammalian target of rapamycin is an adverse prognostic factor in patients with biliary tract adenocarcinoma

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

Overexpression of phospho-eIF4E is associated with survival through AKT pathway in non-small cell lung cancer.

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

The expression of phospho-AKT, phospho-mTOR, and PTEN in extrahepatic cholangiocarcinoma.

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

Serine/threonine kinase AKT is frequently activated in human bile duct cancer and is associated with increased radioresistance.

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

Akt expression may predict favorable prognosis in cholangiocarcinoma.

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

AKT and ERK1/2 signaling in intrahepatic cholangiocarcinoma

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

Insulin-like growth factor-mediated muscle cell survival: central roles for Akt and cyclin-dependent kinase inhibitor p21

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https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

Phosphatidylinositol 3-kinase/Akt positively regulates fas (CD95)-mediated apoptosis in epidermal Cl41 cells

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species up-regulation and genetic instability

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS elimination

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

Insulin-like growth factor-I inhibits cell growth in the a549 non-small lung cancer cell line

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocyte-derived cell line H9c2.

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

High expression of mammalian target of rapamycin is associated with better outcome for patients with early stage lung adenocarcinoma

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

The role of mTOR and phospho-p70S6K in pathogenesis and progression of gastric carcinomas: an immunohistochemical study on tissue microarray

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

Phospho-akt expression is associated with a favorable outcome in non-small cell lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer

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https://api.crossref.org/works/10.1038%2FMODPATHOL.2011.133

21 January 2018

Non-small cell lung cancers frequently express phosphorylated Akt; an immunohistochemical study.

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21 January 2018

Concomitant activation of AKT with extracellular-regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss.

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21 January 2018

The role of PTEN and its signalling pathways, including AKT, in breast cancer; an assessment of relationships with other prognostic factors and with outcome.

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21 January 2018

The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells

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21 January 2018

Multi-disciplinary treatment for cholangiocellular carcinoma

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21 January 2018

Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas

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7 January 2021

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