Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis (Q46250285)

http://europepmc.org/abstract/MED/19005074

20 December 2017

title

Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis (English)

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http://europepmc.org/abstract/MED/19005074

20 December 2017

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3

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16 May 2020

Ilse Dewachter

5

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Peter Henry St George-Hyslop

16 May 2020

7

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16 May 2020

Jochen Walter

15

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16 May 2020

author name string

Irfan Y Tamboli

1

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16 May 2020

Kai Prager

2

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16 May 2020

Karin M Thelen

4

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16 May 2020

Claus U Pietrzik

6

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16 May 2020

Sangram S Sisodia

8

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16 May 2020

Michael T Heneka

10

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16 May 2020

Mikhail A Filippov

11

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16 May 2020

Ulrike Müller

12

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16 May 2020

Fred van Leuven

13

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16 May 2020

Dieter Lütjohann

14

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16 May 2020

Bart De Strooper

9

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16 May 2020

language of work or name

English

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publication date

1 November 2008

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http://europepmc.org/abstract/MED/19005074

20 December 2017

published in

Journal of Neuroscience

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16 May 2020

volume

28

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16 May 2020

issue

46

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16 May 2020

page(s)

12097-12106

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Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein.

16 May 2020

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Phosphorylation regulates intracellular trafficking of beta-secretase

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Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

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gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

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Lipoprotein receptors in the nervous system

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Role of glia in synapse development.

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The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing

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The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinery

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The role of the carboxyl-terminal fragments of amyloid precursor protein in Alzheimer's disease.

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Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

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Autosomal recessive hypercholesterolemia protein interacts with and regulates the cell surface level of Alzheimer's amyloid beta precursor protein

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Cholesterol homeostasis and function in neurons of the central nervous system

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12 December 2020

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

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12 December 2020

Potential Role of Endogenous and Exogenous Amyloid-Beta Binding Molecules in the Pathogenesis, Diagnosis, and Treatment of Alzheimer Disease

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The genetics of adult-onset neuropsychiatric disease: complexities and conundra?

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Apolipoprotein E, amyloid, and Alzheimer disease

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Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation.

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Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

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FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein.

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Gamma-secretase: proteasome of the membrane?

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Intramembrane proteolysis: theme and variations.

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Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

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Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide

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High-dose statins and skeletal muscle metabolism in humans: a randomized, controlled trial

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A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein

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Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner.

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12 December 2020

Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

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12 December 2020

Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation

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12 December 2020

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

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12 December 2020

Protein sensors for membrane sterols

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12 December 2020

A partial failure of membrane protein turnover may cause Alzheimer's disease: a new hypothesis.

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12 December 2020

Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface

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12 December 2020

Presenilin/gamma-secretase activity regulates protein clearance from the endocytic recycling compartment.

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12 December 2020

Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40.

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The nucleation growth and reversibility of Amyloid-beta deposition in vivo.

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GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide.

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Presenilin diversifies its portfolio.

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Receptor-Mediated Control of Cholesterol Metabolism

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The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.

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Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

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Presenilin: running with scissors in the membrane

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Building gamma-secretase: the bits and pieces

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Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

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The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

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12 December 2020

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

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12 December 2020

Skeletal and CNS defects in Presenilin-1-deficient mice

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12 December 2020

Hyperaccumulation of FAD-linked presenilin 1 variants in vivo.

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12 December 2020

Neuronal expression of beta-amyloid precursor protein Alzheimer mutations causes intracellular accumulation of a C-terminal fragment containing both the amyloid beta and cytoplasmic domains.

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12 December 2020

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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12 December 2020

Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice

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12 December 2020

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein

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12 December 2020

Effects of PS1 deficiency on membrane protein trafficking in neurons.

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12 December 2020

10.1523/JNEUROSCI.2635-08.2008

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671640&resulttype=core&format=json

16 May 2020

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16 May 2020

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