GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide. (Q48345479)

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22 December 2019

title

GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide (English)

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22 December 2019

2

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22 December 2019

Andrea Rentmeister

4

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22 December 2019

author name string

Tina Wahle

1

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22 December 2019

Magdalena Sastre

3

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22 December 2019

Nenad Bogdanovic

5

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22 December 2019

Michael Famulok

6

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22 December 2019

Michael T Heneka

7

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22 December 2019

Jochen Walter

8

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22 December 2019

language of work or name

English

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publication date

1 December 2006

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22 December 2019

published in

Journal of Neuroscience

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22 December 2019

volume

26

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22 December 2019

issue

49

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22 December 2019

page(s)

12838-12846

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

22 December 2019

cites work

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12 December 2020

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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12 December 2020

Purification and cloning of amyloid precursor protein beta-secretase from human brain

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12 December 2020

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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12 December 2020

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

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12 December 2020

A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome

1 reference

12 December 2020

GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex

1 reference

12 December 2020

A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi

1 reference

12 December 2020

Maturation and pro-peptide cleavage of beta-secretase

1 reference

12 December 2020

mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors

1 reference

12 December 2020

Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

1 reference

12 December 2020

Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

1 reference

12 December 2020

Abeta-generating enzymes: recent advances in beta- and gamma-secretase research

1 reference

12 December 2020

Processing of beta-secretase by furin and other members of the proprotein convertase family

1 reference

12 December 2020

Alzheimer's disease: genes, proteins, and therapy

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12 December 2020

Phosphorylation regulates intracellular trafficking of beta-secretase

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12 December 2020

Sorting of mannose 6-phosphate receptors mediated by the GGAs

1 reference

12 December 2020

Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor

1 reference

12 December 2020

Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis

1 reference

12 December 2020

The cell biology of Alzheimer's disease: uncovering the secrets of secretases

1 reference

12 December 2020

The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding

1 reference

12 December 2020

The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta).

1 reference

12 December 2020

Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression

1 reference

12 December 2020

A non-amyloidogenic function of BACE-2 in the secretory pathway

1 reference

12 December 2020

Phases of A beta-deposition in the human brain and its relevance for the development of AD.

1 reference

12 December 2020

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

1 reference

12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

12 December 2020

Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2

1 reference

12 December 2020

A cell biological perspective on Alzheimer's disease

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12 December 2020

Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network

1 reference

12 December 2020

Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation

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12 December 2020

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

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12 December 2020

Phosphorylation-induced conformational changes regulate GGAs 1 and 3 function at the trans-Golgi network

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12 December 2020

Amyloid beta-peptide is produced by cultured cells during normal metabolism

1 reference

12 December 2020

Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins

1 reference

12 December 2020

Games played by rogue proteins in prion disorders and Alzheimer's disease

1 reference

12 December 2020

Vascular pathology in Alzheimer disease: correlation of cerebral amyloid angiopathy and arteriosclerosis/lipohyalinosis with cognitive decline

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12 December 2020

The GGA proteins: adaptors on the move

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12 December 2020

Insights into the phosphoregulation of beta-secretase sorting signal by the VHS domain of GGA1.

1 reference

12 December 2020

Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy

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12 December 2020

GGA proteins mediate the recycling pathway of memapsin 2 (BACE).

1 reference

12 December 2020

BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo

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12 December 2020

GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network

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12 December 2020

Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide

1 reference

12 December 2020

Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma

1 reference

12 December 2020

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme

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12 December 2020

The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments

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12 December 2020

Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11.

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12 December 2020

Neuropathological stageing of Alzheimer-related changes

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12 December 2020

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

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12 December 2020

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

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12 December 2020

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

1 reference

12 December 2020

Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease

1 reference

12 December 2020

TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking

1 reference

12 December 2020

10.1523/JNEUROSCI.1982-06.2006

Identifiers

DOI

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22 December 2019

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