The involvement of hypothalamic sleep pathways in general anesthesia: testing the hypothesis using the GABAA receptor beta3N265M knock-in mouse (Q46116548)

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scientific article published in February 2009

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English	The involvement of hypothalamic sleep pathways in general anesthesia: testing the hypothesis using the GABAA receptor beta3N265M knock-in mouse	scientific article published in February 2009

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scholarly article

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Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19228970

The involvement of hypothalamic sleep pathways in general anesthesia: testing the hypothesis using the GABAA receptor beta3N265M knock-in mouse (English)

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19228970

general anaesthesia

1 reference

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inferred from title

Nicholas Franks

9

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15 May 2020

3

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15 May 2020

Stephen G Brickley

7

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15 May 2020

author name string

Anna Y Zecharia

1

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15 May 2020

Laura E Nelson

2

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15 May 2020

Mark Schumacher

4

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15 May 2020

Rachel Jurd

5

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15 May 2020

Uwe Rudolph

6

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15 May 2020

Mervyn Maze

8

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15 May 2020

language of work or name

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publication date

1 February 2009

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Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19228970

Journal of Neuroscience

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15 May 2020

29

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15 May 2020

7

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15 May 2020

2177-2187

1 reference

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15 May 2020

Activation of rat locus coeruleus neuron GABA(A) receptors by propofol and its potentiation by pentobarbital or alphaxalone.

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https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

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The posterior hypothalamic area: chemoarchitecture and afferent connections

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https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

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Fos expression in orexin neurons varies with behavioral state.

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https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

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Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons.

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https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

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Prolonged sedation with propofol in the rat does not result in sleep deprivation

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https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

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Arousal effect of orexin A depends on activation of the histaminergic system

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https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

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Hypocretin-2-saporin lesions of the lateral hypothalamus produce narcoleptic-like sleep behavior in the rat.

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https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

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Reversible analgesia, atonia, and loss of consciousness on bilateral intracerebral microinjection of pentobarbital

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular determinants for the action of general anesthetics at recombinant alpha(2)beta(3)gamma(2)gamma-aminobutyric acid(A) receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sleep-waking discharge patterns of median preoptic nucleus neurons in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sleep deprivation potentiates the onset and duration of loss of righting reflex induced by propofol and isoflurane

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The wake-promoting hypocretin-orexin neurons are in an intrinsic state of membrane depolarization.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced inhibition and sensitivity to neurosteroids in hippocampus of mice lacking the GABA(A) receptor delta subunit

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https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

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Effects of sevoflurane, propofol, and adjunct nitrous oxide on regional cerebral blood flow, oxygen consumption, and blood volume in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

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A hypnotic response to dexmedetomidine, an alpha 2 agonist, is mediated in the locus coeruleus in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

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Inhibition of adenylate cyclase in the locus coeruleus mediates the hypnotic response to an alpha 2 agonist in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

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Orexinergic neurons and barbiturate anesthesia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

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Wake-related activity of tuberomammillary neurons in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

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The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Halothane and propofol modulation of gamma-aminobutyric acidA receptor single-channel currents

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular and neuronal substrates for general anaesthetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

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Determination of diffusion and partition coefficients of propofol in rat brain tissue: implications for studies of drug action in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

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GABA-mediated control of hypocretin- but not melanin-concentrating hormone-immunoreactive neurones during sleep in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

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Pharmacological properties of GABAA receptors in rat hypothalamic neurons expressing the epsilon-subunit.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

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Opposite effects of noradrenaline and acetylcholine upon hypocretin/orexin versus melanin concentrating hormone neurons in rat hypothalamic slices

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct molecular targets for the central respiratory and cardiac actions of the general anesthetics etomidate and propofol

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

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S-ketamine anesthesia increases cerebral blood flow in excess of the metabolic needs in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

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Sleep, anesthesiology, and the neurobiology of arousal state control.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual actions of enflurane on postsynaptic currents abolished by the gamma-aminobutyric acid type A receptor beta3(N265M) point mutation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal activity of histaminergic tuberomammillary neurons during wake-sleep states in the mouse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a molecular target mediating the general anesthetic actions of pentobarbital.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mapping the contribution of beta3-containing GABAA receptors to volatile and intravenous general anesthetic actions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Propofol enhances both tonic and phasic inhibitory currents in second-order neurons of the solitary tract nucleus (NTS).

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An essential role for orexins in emergence from general anesthesia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imaging the spread of reversible brain inactivations using fluorescent muscimol

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of endogenous sleep-wake and analgesic systems in anesthesia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central Catecholamine Neuron Systems: Anatomy and Physiology of the Norepinephrine and Epinephrine Systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of alpha 2-adrenoceptors which increase potassium conductance in rat locus coeruleus neurones.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The organization and hypothalamic projections of the tuberomammillary nucleus in the rat: an immunohistochemical study of adenosine deaminase-positive neurons and fibers

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A steroid anesthetic prolongs inhibitory postsynaptic currents in cultured rat hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histamine-containing neurons in the rat hypothalamus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular and cellular mechanisms of general anaesthesia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Propofol modulates activation and desensitization of GABAA receptors in cultured murine hippocampal neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

c-Fos and related immediate early gene products as markers of activity in neuroendocrine systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of ventrolateral preoptic neurons during sleep

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions between neuronal histamine and halothane anesthesia in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isoflurane.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stereoselective effects of etomidate optical isomers on gamma-aminobutyric acid type A receptors and animals

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Innervation of histaminergic tuberomammillary neurons by GABAergic and galaninergic neurons in the ventrolateral preoptic nucleus of the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anesthetic effects on electrophysiologic recordings

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sleep-waking discharge patterns of ventrolateral preoptic/anterior hypothalamic neurons in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurons containing hypocretin (orexin) project to multiple neuronal systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19228970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.4997-08.2009

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6666350&resulttype=core&format=json

15 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6666350&resulttype=core&format=json

15 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6666350&resulttype=core&format=json

15 May 2020

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