Interleukin (IL)-21 and IL-15 genetic transfer synergistically augments therapeutic antitumor immunity and promotes regression of metastatic lymphoma. (Q45869303)

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scientific article published in October 2003

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English	Interleukin (IL)-21 and IL-15 genetic transfer synergistically augments therapeutic antitumor immunity and promotes regression of metastatic lymphoma.	scientific article published in October 2003

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scholarly article

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19 December 2019

Interleukin (IL)-21 and IL-15 genetic transfer synergistically augments therapeutic antitumor immunity and promotes regression of metastatic lymphoma (English)

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19 December 2019

Hidetsugu Asada

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19 December 2019

author name string

Tsunao Kishida

1

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19 December 2019

Yoshiki Itokawa

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19 December 2019

Feng-De Cui

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19 December 2019

Masaharu Shin-Ya

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19 December 2019

Satoshi Gojo

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19 December 2019

Kakei Yasutomi

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19 December 2019

Yuji Ueda

8

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19 December 2019

Hisakazu Yamagishi

9

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19 December 2019

Jiro Imanishi

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19 December 2019

Osam Mazda

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19 December 2019

publication date

1 October 2003

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19 December 2019

Molecular Therapy

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19 December 2019

8

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19 December 2019

4

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19 December 2019

552-558

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19 December 2019

Cytokine therapy for cancer

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7 January 2021

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Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

1 reference

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Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex

1 reference

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7 January 2021

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The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3

1 reference

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7 January 2021

based on heuristic

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IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity

1 reference

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7 January 2021

based on heuristic

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IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response

1 reference

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7 January 2021

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Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line C(epsilon) transcription of IL-4-stimulated B cells

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A critical role for IL-21 in regulating immunoglobulin production

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7 January 2021

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Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor

1 reference

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7 January 2021

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Critical role for IL-15 in innate immunity

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7 January 2021

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The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens

1 reference

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7 January 2021

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Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor

1 reference

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7 January 2021

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A potential role for interleukin-15 in the regulation of human natural killer cell survival

1 reference

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7 January 2021

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In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells

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Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15.

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Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice

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7 January 2021

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Chemoattraction of human blood T lymphocytes by interleukin-15.

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7 January 2021

based on heuristic

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Cutting edge: IL-15 costimulates the generalized Shwartzman reaction and innate immune IFN-gamma production in vivo

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Highly efficient gene transfer into murine liver achieved by intravenous administration of naked Epstein-Barr virus (EBV)-based plasmid vectors.

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Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells

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Interleukin-21 is a growth and survival factor for human myeloma cells

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Interleukin 15-mediated induction of cytotoxic effector cells capable of eliminating Epstein-Barr virus-transformed/immortalized lymphocytes in culture.

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Significant Antitumor Effects Obtained by Autologous Tumor Cell Vaccine Engineered to Secrete Interleukin (IL)-12 and IL-18 by Means of the EBV/Lipoplex

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IL-18 and IL-12 induce intestinal inflammation and fatty liver in mice in an IFN-gamma dependent manner

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Expression of the interleukin-21 gene in murine colon carcinoma cells generates systemic immunity in the inoculated hosts

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7 January 2021

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Development of catheter-based procedures for transducing the isolated rabbit liver with plasmid DNA.

1 reference

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7 January 2021

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7 January 2021

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Identifiers

10.1016/S1525-0016(03)00222-3

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Europe PubMed Central

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19 December 2019

1 reference

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19 December 2019

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