Expanded CTG repeats trigger miRNA alterations in Drosophila that are conserved in myotonic dystrophy type 1 patients. (Q45771202)

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17 February 2020

title

Expanded CTG repeats trigger miRNA alterations in Drosophila that are conserved in myotonic dystrophy type 1 patients (English)

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17 February 2020

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Juan M Fernandez-Costa

1

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Sheila Zuniga

3

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Amelia Felipo-Benavent

5

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Francisco Hernández-Torres

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9

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Adolfo López de Munain

13

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author name string

Amparo Garcia-Lopez

2

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Victoria Fernandez-Pedrosa

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Manuel Mata

6

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Oihane Jaka

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Ana Aiastui

8

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Begoña Aguado

10

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Manuel Perez-Alonso

11

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Jesus J Vilchez

12

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Ruben D Artero

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publication date

8 November 2012

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17 February 2020

published in

Human Molecular Genetics

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volume

22

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issue

4

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page(s)

704-716

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Myotonic dystrophy, when simple repeats reveal complex pathogenic entities: new findings and future challenges

17 February 2020

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Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylation

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Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy

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Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG repeats expanded in myotonic dystrophy

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A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart

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Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy

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Transgenic mice expressing CUG-BP1 reproduce splicing mis-regulation observed in myotonic dystrophy.

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Identification of restriction endonucleases sensitive to 5-cytosine methylation at non-CpG sites, including expanded (CAG)n/(CTG)n repeats.

21 January 2018

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Expanded CTG repeat demarcates a boundary for abnormal CpG methylation in myotonic dystrophy patient tissues

21 January 2018

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Overexpression of microRNA-206 in the skeletal muscle from myotonic dystrophy type 1 patients.

21 January 2018

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Mammalian microRNAs predominantly act to decrease target mRNA levels

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microRNAs: tiny regulators with great potential

21 January 2018

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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

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microRNA: emerging therapeutic targets in acute ischemic diseases

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MicroRNAs flex their muscles

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Variant CCG and GGC repeats within the CTG expansion dramatically modify mutational dynamics and likely contribute toward unusual symptoms in some myotonic dystrophy type 1 patients.

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A novel repeat structure at the myotonic dystrophy locus in a 37 repeat allele with unexpectedly high stability

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21 January 2018

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Dysregulation and cellular mislocalization of specific miRNAs in myotonic dystrophy type 1

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/HMG/DDS478

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23139243%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

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