An oncogenic role of eIF3e/INT6 in human breast cancer (Q45384502)

14 December 2017

An oncogenic role of eIF3e/INT6 in human breast cancer (English)

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M Grzmil

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T Rzymski

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M Milani

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R G Capper

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A Salhan

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J Ragoussis

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C J Norbury

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language of work or name

English

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publication date

10 May 2010

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14 December 2017

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29

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4080-4089

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28

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https://scigraph.springernature.com/pub.10.1038/onc.2010.152

14 December 2017

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Fission yeast Int6 is not essential for global translation initiation, but deletion of int6(+) causes hypersensitivity to caffeine and affects spore formation

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Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle

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Functional analysis of the interaction between HCV 5'UTR and putative subunits of eukaryotic translation initiation factor eIF3

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Int6 expression can predict survival in early-stage non-small cell lung cancer patients.

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Mammalian tumor suppressor Int6 specifically targets hypoxia inducible factor 2 alpha for degradation by hypoxia- and pVHL-independent regulation

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A fission yeast homolog of Int-6, the mammalian oncoprotein and eIF3 subunit, induces drug resistance when overexpressed

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Initiation factor eIF3 and regulation of mRNA translation, cell growth, and cancer

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The INT6 cancer gene and MEK signaling pathways converge during zebrafish development

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eIF3: a versatile scaffold for translation initiation complexes

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Translational control in stress and apoptosis

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Eukaryotic translation initiation factor 3 (eIF3) and eIF2 can promote mRNA binding to 40S subunits independently of eIF4G in yeast

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IRES interaction with translation initiation factors: functional characterization of novel RNA contacts with eIF3, eIF4B, and eIF4GII.

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Expression of truncated Int6/eIF3e in mammary alveolar epithelium leads to persistent hyperplasia and tumorigenesis

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Translational control and cancer therapy

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Malignant transformation by the eukaryotic translation initiation factor 3 subunit p48 (eIF3e).

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MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells

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The chromosome location of the human homolog of the mouse mammary tumor-associated gene INT6 and its status in human breast carcinomas

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Local regulation of mRNA translation: new insights from the bud.

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Evidence for the transforming activity of a truncated Int6 gene, in vitro

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The proto-oncogene Int6 is essential for neddylation of Cul1 and Cul3 in Drosophila.

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BioArray Software Environment (BASE): a platform for comprehensive management and analysis of microarray data.

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Overexpression of EIF3S3 promotes cancer cell growth

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Structural roles for human translation factor eIF3 in initiation of protein synthesis

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Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

21 January 2018

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Translational control: a target for cancer therapy

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Int6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 MAPK-dependent stress response in fission yeast

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Protein homeostasis: a degrading role for Int6/eIF3e

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Translation initiation and its deregulation during tumorigenesis

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Dissecting eIF4E action in tumorigenesis

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Subcellular localisation of cyclin B, Cdc2 and p21(WAF1/CIP1) in breast cancer. association with prognosis

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Schizosaccharomyces pombe Int6 and Ras homologs regulate cell division and mitotic fidelity via the proteasome

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Individual overexpression of five subunits of human translation initiation factor eIF3 promotes malignant transformation of immortal fibroblast cells

21 January 2018

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PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes

21 January 2018

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Expression of EIF3-p48/INT6, TID1 and Patched in cancer, a profiling of multiple tumor types and correlation of expression

21 January 2018

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Silencing of human Int-6 impairs mitosis progression and inhibits cyclin B-Cdk1 activation

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.152

31 March 2020

Identifiers

DOI

10.1038/ONC.2010.152

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Dimensions Publication ID

14 December 2017

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