Huntington's disease: flipping a switch on huntingtin (Q45303341)

11 December 2017

Huntington's disease: flipping a switch on huntingtin (English)

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11 December 2017

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Erin R Greiner

1

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PubMed ID

21685885

11 December 2017

X William Yang

series ordinal

2

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11 December 2017

17 June 2011

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11 December 2017

Nature Chemical Biology

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11 December 2017

7

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11 December 2017

7

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11 December 2017

412-414

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https://scigraph.springernature.com/pub.10.1038/nchembio.604

11 December 2017

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cites work

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.604

Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.604

Kinase inhibitors modulate huntingtin cell localization and toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.604

Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.604

The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.604

Polyglutamine expansion of huntingtin impairs its nuclear export

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.604

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.604

The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.604

SUMO modification of Huntingtin and Huntington's disease pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.604

Preferential accumulation of N-terminal mutant huntingtin in the nuclei of striatal neurons is regulated by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.604

21 January 2018

Identifiers

DOI

10.1038/NCHEMBIO.604

1 reference

PubMed ID

21685885

Dimensions Publication ID

11 December 2017

0 references

1 reference

PubMed ID

21685885