Polyglutamine expansion of huntingtin impairs its nuclear export (Q24338269)

GOA release 2020-03-11

Huntingtin

1 reference

GOA release 2020-03-11

Gillian P Bates

5

0 references

Christopher A Ross

4

object named as

Christopher A Ross

0 references

author name string

Jonathan Cornett

1

0 references

Fengli Cao

2

0 references

Chuan-En Wang

3

0 references

Shi-Hua Li

6

0 references

Xiao-Jiang Li

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

7

0 references

language of work or name

English

0 references

publication date

February 2005

0 references

published in

Nature Genetics

0 references

volume

37

0 references

issue

2

0 references

page(s)

198-204

0 references

cites work

1 reference

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

20 April 2017

1 reference

Transport between the cell nucleus and the cytoplasm

20 April 2017

1 reference

The hunt for huntingtin function: interaction partners tell many different stories

20 April 2017

1 reference

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

20 April 2017

1 reference

Identification of protein p270/Tpr as a constitutive component of the nuclear pore complex-attached intranuclear filaments

20 April 2017

1 reference

Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export

20 April 2017

1 reference

Nucleocytoplasmic transport of proteins and poly(A)+ RNA in reconstituted Tpr-less nuclei in living mammalian cells

20 April 2017

1 reference

SUMO modification of Huntingtin and Huntington's disease pathology

20 April 2017

1 reference

Huntingtin contains a highly conserved nuclear export signal

20 April 2017

1 reference

Nucleocytoplasmic transport signals affect the age at onset of abnormalities in knock-in mice expressing polyglutamine within an ectopic protein context

20 April 2017

1 reference

A huntingtin-associated protein enriched in brain with implications for pathology

20 April 2017

1 reference

Glutamine repeats and neurodegeneration

20 April 2017

1 reference

Transcriptional abnormalities in Huntington disease

21 January 2018

1 reference

Widespread expression of Huntington's disease gene (IT15) protein product

21 January 2018

1 reference

Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies

21 January 2018

1 reference

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

21 January 2018

1 reference

Modulating huntingtin half-life alters polyglutamine-dependent aggregate formation and cell toxicity

21 January 2018

1 reference

Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation

21 January 2018

1 reference

Nucleocytoplasmic recycling of the nuclear localization signal receptor alpha subunit in vivo is dependent on a nuclear export signal, energy, and RCC1

21 January 2018

1 reference

beta-subunit of nuclear pore-targeting complex (importin-beta) can be exported from the nucleus in a Ran-independent manner

21 January 2018

1 reference

beta-catenin can be transported into the nucleus in a Ran-unassisted manner

21 January 2018

1 reference

Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

21 January 2018

1 reference

Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity.

21 January 2018

1 reference

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

1 reference

Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation

21 January 2018

1 reference

The evolutionarily conserved single-copy gene for murine Tpr encodes one prevalent isoform in somatic cells and lacks paralogs in higher eukaryotes

21 January 2018

1 reference

Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex

21 January 2018

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NG1503

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1036279529

0 references

Fatcat ID

release_fmufomknd5hepelwmayq73nlqa

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/fmufomknd5hepelwmayq73nlqa

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

15654337

1 reference

Consolidated OpenCitations Corpus – April 2017