Motor deficits associated with Huntington's disease occur in the absence of striatal degeneration in BACHD transgenic mice (Q45293567)

11 December 2017

Motor deficits associated with Huntington's disease occur in the absence of striatal degeneration in BACHD transgenic mice (English)

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11 December 2017

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11 December 2017

Daniel C Christie

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Trent M. Woodruff

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Trent M Woodruff

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Richard Gordon

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Richard Gordon

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author name string

Rui Li

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PubMed ID

26908618

11 December 2017

Vinod Kumar

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11 December 2017

21 February 2016

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11 December 2017

Human Molecular Genetics

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11 December 2017

25

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11 December 2017

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11 December 2017

1780-1791

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Neuroinflammation in Huntington's disease

11 December 2017

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Huntington's disease: from molecular pathogenesis to clinical treatment

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Choosing an animal model for the study of Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Body weight is modulated by levels of full-length huntingtin

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Increased Body Weight of the BAC HD Transgenic Mouse Model of Huntington's Disease Accounts for Some but Not All of the Observed HD-like Motor Deficits.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Progressive synaptic pathology of motor cortical neurons in a BAC transgenic mouse model of Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Motor, emotional and cognitive deficits in adult BACHD mice: a model for Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

New anti-huntingtin monoclonal antibodies: implications for huntingtin conformation and its binding proteins

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

The neurobiology of anhedonia and other reward-related deficits

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation toward authentic DARPP-32+ medium-sized spiny neurons

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Quantitative immunocytochemistry of DARPP-32-expressing neurons in the rat caudatoputamen.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Selective deficits in the expression of striatal-enriched mRNAs in Huntington's disease.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Effects of partial suppression of parkin on huntingtin mutant R6/1 mice.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

N-Acetylaspartate and DARPP-32 levels decrease in the corpus striatum of Huntington's disease mice

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Neurovascular abnormalities in humans and mice with Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Mouse models of Huntington's disease and methodological considerations for therapeutic trials

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Synaptic scaling up in medium spiny neurons of aged BACHD mice: A slow-progression model of Huntington's disease.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Mouse models of Huntington disease: variations on a theme.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Transgenic models of Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Baroreceptor reflex dysfunction in the BACHD mouse model of Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Effects of deletion of mutant huntingtin in steroidogenic factor 1 neurons on the psychiatric and metabolic phenotype in the BACHD mouse model of Huntington disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Impaired brain energy metabolism in the BACHD mouse model of Huntington's disease: critical role of astrocyte-neuron interactions

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Enhanced Ca(2+)-dependent glutamate release from astrocytes of the BACHD Huntington's disease mouse model

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Differential effects of unilateral striatal and nigrostriatal lesions on grip strength, skilled paw reaching and drug-induced rotation in the rat.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Expression of mutant huntingtin in leptin receptor-expressing neurons does not control the metabolic and psychiatric phenotype of the BACHD mouse

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Transcriptomic indices of fast and slow disease progression in two mouse models of amyotrophic lateral sclerosis.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Parkinson's disease mouse models in translational research

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Retinal degeneration mutants in the mouse

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Behavioral and neuroanatomical characterization of FVB/N inbred mice.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Behavior and stress reactivity in mouse strains with mitochondrial DNA variations

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Early and progressive accumulation of reactive microglia in the Huntington disease brain

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Microglial activation correlates with severity in Huntington disease: a clinical and PET study.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Huntington's disease: can mice lead the way to treatment?

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Hypothalamic expression of mutant huntingtin contributes to the development of depressive-like behavior in the BAC transgenic mouse model of Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Dysfunctions in circadian behavior and physiology in mouse models of Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

Depression and Stages of Huntington's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW050

21 January 2018

Identifiers

DOI

10.1093/HMG/DDW050

1 reference

11 December 2017

1 reference

PubMed ID

26908618