Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment. (Q36266600)

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English	Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment.	scientific article

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2 February 2020

Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment (English)

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Kimmo K Lehtimäki

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Lisa M Ellerby

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Juliette Gafni

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Theodora Papanikolaou

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Francesco Degiacomo

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Jennifer Holcomb

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Sylvia Chen

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Liliana Menalled

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Andrea Kudwa

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Jon Fitzpatrick

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Sam Miller

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Sylvie Ramboz

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Pasi I Tuunanen

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X William Yang

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Larry Park

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Seung Kwak

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David Howland

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Hyunsun Park

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1 May 2012

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2 February 2020

Journal of Neuroscience

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7454-7465

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2 February 2020

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3454486/fullTextXML

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Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454486

30 September 2017

Mass spectrometric identification of novel lysine acetylation sites in huntingtin

1 reference

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30 September 2017

Familial amyloid precursor protein mutants cause caspase-6-dependent but amyloid β-peptide-independent neuronal degeneration in primary human neuron cultures

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30 September 2017

Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models

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30 September 2017

Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454486

30 September 2017

Caspase-6 activation in familial alzheimer disease brains carrying amyloid precursor protein or presenilin i or presenilin II mutations

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30 September 2017

Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models

1 reference

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30 September 2017

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

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30 September 2017

Aggregation of expanded huntingtin in the brains of patients with Huntington disease.

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30 September 2017

Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice

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30 September 2017

Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454486

30 September 2017

Activation of caspase-6 in aging and mild cognitive impairment

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30 September 2017

Aging and neurodegeneration. Molecular mechanisms of neuronal loss in Huntington's disease

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30 September 2017

Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease

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30 September 2017

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

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30 September 2017

Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus

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30 September 2017

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

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30 September 2017

Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

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30 September 2017

Calpain activation in Huntington's disease.

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30 September 2017

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

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30 September 2017

Neurological abnormalities in a knock-in mouse model of Huntington's disease

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30 September 2017

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

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30 September 2017

Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells

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30 September 2017

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

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30 September 2017

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

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30 September 2017

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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30 September 2017

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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30 September 2017

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454486

30 September 2017

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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"Autophagic flux" in normal mouse tissues: focus on endogenous LC3A processing

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29 June 2018

Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454486

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The in vitro cleavage of the hAtg proteins by cell death proteases

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29 June 2018

Acetylation targets mutant huntingtin to autophagosomes for degradation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454486

29 June 2018

Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

1 reference

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Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease

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22 September 2018

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22 September 2018

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

1 reference

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22 September 2018

Body weight is modulated by levels of full-length huntingtin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454486

22 September 2018

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454486

22 September 2018

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454486

22 September 2018

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

1 reference

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22 September 2018

Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22649225

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Compensatory caspase activation: a cautionary tale

1 reference

https://pubmed.ncbi.nlm.nih.gov/22649225

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imaging polyglutamine deposits in brain tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/22649225

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1523/JNEUROSCI.6379-11.2012

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2 February 2020

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2 February 2020

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2 February 2020

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