In vivo evidence for NMDA receptor-mediated excitotoxicity in a murine genetic model of Huntington disease. (Q45293042)

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23 January 2020

title

In vivo evidence for NMDA receptor-mediated excitotoxicity in a murine genetic model of Huntington disease (English)

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23 January 2020

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Mary Y Heng

1

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23 January 2020

Peter J Detloff

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23 January 2020

Phillip L Wang

3

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23 January 2020

Joe Z Tsien

4

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23 January 2020

Roger L Albin

5

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23 January 2020

language of work or name

English

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publication date

1 March 2009

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23 January 2020

published in

Journal of Neuroscience

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23 January 2020

volume

29

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23 January 2020

page(s)

3200-3205

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23 January 2020

issue

10

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The glutamate receptor ion channels

23 January 2020

cites work

1 reference

12 December 2020

Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin

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12 December 2020

The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro

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12 December 2020

Are there multiple pathways in the pathogenesis of Huntington's disease?

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12 December 2020

Genetic enhancement of learning and memory in mice

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12 December 2020

Enhanced sensitivity to N-methyl-D-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease

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12 December 2020

Mutant huntingtin enhances excitotoxic cell death.

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12 December 2020

NMDA receptor subunits: diversity, development and disease

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12 December 2020

NMDA receptor function in mouse models of Huntington disease

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12 December 2020

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12 December 2020

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease

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12 December 2020

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

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12 December 2020

The N-methyl-D-aspartate receptor subunit NR2B: localization, functional properties, regulation, and clinical implications.

1 reference

12 December 2020

Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1

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12 December 2020

Heteromeric NMDA receptors: molecular and functional distinction of subtypes

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12 December 2020

Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease

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12 December 2020

Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease

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12 December 2020

Enhanced striatal NR2B-containing N-methyl-D-aspartate receptor-mediated synaptic currents in a mouse model of Huntington disease

1 reference

12 December 2020

Deranged neuronal calcium signaling and Huntington disease.

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12 December 2020

N-methyl-D-aspartate receptor subtypes: multiple roles in excitotoxicity and neurological disease

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12 December 2020

Neuronal intranuclear inclusions and neuropil aggregates in HdhCAG(150) knockin mice

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12 December 2020

Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease

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12 December 2020

N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease

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12 December 2020

NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo.

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12 December 2020

Maintenance of superior learning and memory function in NR2B transgenic mice during ageing

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12 December 2020

Longitudinal evaluation of the Hdh(CAG)150 knock-in murine model of Huntington's disease

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12 December 2020

The dichotomy of NMDA receptor signaling.

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12 December 2020

Neuroprotective effects of synaptic modulation in Huntington's disease R6/2 mice.

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12 December 2020

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

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12 December 2020

In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death

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12 December 2020

Huntington's disease: from pathology and genetics to potential therapies

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12 December 2020

Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.

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12 December 2020

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

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12 December 2020

Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain

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12 December 2020

Characterization of the excitotoxic potential of the reversible succinate dehydrogenase inhibitor malonate

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12 December 2020

Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates

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12 December 2020

Cloned glutamate receptors

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12 December 2020

Chronic intrastriatal dialytic administration of quinolinic acid produces selective neural degeneration.

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12 December 2020

Excitotoxin lesions in primates as a model for Huntington's disease: histopathologic and neurochemical characterization

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12 December 2020

Striatal D1 and D2 dopamine receptor loss in asymptomatic mutation carriers of Huntington's disease

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12 December 2020

Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea

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12 December 2020

Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids

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12 December 2020

10.1523/JNEUROSCI.5599-08.2009

Identifiers

DOI

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23 January 2020

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