Substituted thiazolamide coupled to a redox delivery system: a new gamma-secretase inhibitor with enhanced pharmacokinetic profile. (Q45259689)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15703796%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

title

Substituted thiazolamide coupled to a redox delivery system: a new gamma-secretase inhibitor with enhanced pharmacokinetic profile (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15703796%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15703796%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Frédéric Bihel

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15703796%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

author name string

Younes Laras

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15703796%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Gilles Quéléver

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15703796%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Cédrik Garino

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15703796%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Mahmoud Sheha

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15703796%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Michael S Wolfe

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15703796%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Jean-Louis Kraus

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15703796%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

publication date

10 January 2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15703796%20AND%20SRC:MED&resulttype=core&format=json

Organic and Biomolecular Chemistry

8 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15703796%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

volume

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15703796%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15703796%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

page(s)

612-618

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15703796%20AND%20SRC:MED&resulttype=core&format=json

Lipophilicity in molecular modeling

8 January 2020

cites work

1 reference

Transporter-mediated permeation of drugs across the blood-brain barrier

21 January 2018

1 reference

Nanoparticulate systems for brain delivery of drugs

21 January 2018

1 reference

Biodegradable polymer implants to treat brain tumors

21 January 2018

1 reference

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

21 January 2018

1 reference

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

21 January 2018

1 reference

Translating cell biology into therapeutic advances in Alzheimer's disease

21 January 2018

1 reference

Novel therapeutic strategies provide the real test for the amyloid hypothesis of Alzheimer's disease

21 January 2018

1 reference

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

21 January 2018

1 reference

The gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester reduces A beta levels in vivo in plasma and cerebrospinal fluid in young (plaque-free) and aged (plaque-bearing) Tg2576 mice

21 January 2018

1 reference

A new series of potent benzodiazepine gamma-secretase inhibitors

21 January 2018

1 reference

Aspartic proteases involved in Alzheimer's disease

21 January 2018

1 reference

Studies of Abeta pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[

21 January 2018

1 reference

Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).

21 January 2018

1 reference

A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

21 January 2018

1 reference

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

21 January 2018

1 reference

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

1 reference

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

21 January 2018

1 reference

Positive-negative epitope-tagging of beta amyloid precursor protein to identify inhibitors of A beta processing.

21 January 2018

1 reference

New carrier for specific delivery of drugs to the brain

21 January 2018

1 reference