Brain aging in acquired immunodeficiency syndrome: increased ubiquitin-protein conjugate is correlated with decreased synaptic protein but not amyloid plaque accumulation (Q44942423)

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English	Brain aging in acquired immunodeficiency syndrome: increased ubiquitin-protein conjugate is correlated with decreased synaptic protein but not amyloid plaque accumulation	scientific article

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scholarly article

1 reference

Europe PubMed Central

7 December 2017

Brain aging in acquired immunodeficiency syndrome: increased ubiquitin-protein conjugate is correlated with decreased synaptic protein but not amyloid plaque accumulation (English)

1 reference

Europe PubMed Central

7 December 2017

author name string

Benjamin B Gelman

1

1 reference

Europe PubMed Central

7 December 2017

Kimberly Schuenke

2

1 reference

Europe PubMed Central

7 December 2017

publication date

1 April 2004

1 reference

Europe PubMed Central

7 December 2017

Journal of NeuroVirology

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Europe PubMed Central

7 December 2017

10

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Europe PubMed Central

7 December 2017

2

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Europe PubMed Central

7 December 2017

98-108

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Europe PubMed Central

7 December 2017

https://scigraph.springernature.com/pub.10.1080/13550280490279816

0 references

Protein turnover plays a key role in aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging and proteolysis of oxidized proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ubiquitin-proteasome cascade is required for mammalian long-term memory formation.

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https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

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Explaining neurocognitive aging: is one factor enough?

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https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

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Ubiquitin and the synapse.

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https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

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The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders

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https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

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Degradation of oxidized proteins by the 20S proteasome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decline in deaths from AIDS due to new antiretrovirals

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of pathogenic sets of genes in macrophages and neurons in NeuroAIDS.

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https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dietary restriction initiated in late adulthood can reverse age-related alterations of protein and protein metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

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Protein degradation in Alzheimer's disease and aging of the brain

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https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

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Central nervous system damage, monocytes and macrophages, and neurological disorders in AIDS.

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https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

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Oxidized high-density lipoprotein induces neuron death

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https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

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Impaired proteasome function in Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

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Ubiquitin-specific proteases of Saccharomyces cerevisiae. Cloning of UBP2 and UBP3, and functional analysis of the UBP gene family

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https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

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Human immunodeficiency virus encephalitis is the pathological correlate of dementia in acquired immunodeficiency syndrome

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https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

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Ubiquitination precedes internalization and proteolytic cleavage of plasma membrane-bound glycine receptors

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https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

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Highly active antiretroviral therapy reverses brain metabolite abnormalities in mild HIV dementia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

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Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

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Induction of interleukin-1 and tumor necrosis factor alpha in brain cultures by human immunodeficiency virus type 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

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The "normal" brain. "Abnormal" ubiquitinilated deposits highlight an age-related protein change

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https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

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Ubiquitin immunoreactive structures in normal human brains. Distribution and developmental aspects

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

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Progression of HIV-associated dementia treated with HAART.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related accumulation of high-molecular-weight ubiquitin protein conjugates in mouse brains

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-dependent declines in proteasome activity in the heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impairment of proteasome structure and function in aging.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation, autotoxicity and Alzheimer disease

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https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin and AP180 regulate the abundance of GLR-1 glutamate receptors at postsynaptic elements in C. elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complement and cytokine gene expression in cultured microglial derived from postmortem human brains

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes to AIDS dementia complex in the era of highly active antiretroviral therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-acetylcysteine and celecoxib lessen cadmium cytotoxicity which is associated with cyclooxygenase-2 up-regulation in mouse neuronal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aspects of neurodegeneration in the canine brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The proteasome in brain aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for apoE in regulating the levels of alpha-1-antichymotrypsin in the aging mouse brain and in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodie

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Implications of protein degradation in aging.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impairment of the ubiquitin-proteasome system by protein aggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolysis of oxidised proteins and cellular senescence

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal apoptosis does not correlate with dementia in HIV infection but is related to microglial activation and axonal damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related alterations in the protein expression profile of C57BL/6J mouse pituitaries.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevalence of Alzheimer plaques in AIDS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased levels of proteasome activity and proteasome expression in aging spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation in neurodegenerative disease--a double-edged sword

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A ubiquitin-like protein which is synergistically inducible by interferon-gamma and tumor necrosis factor-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in pathological findings at autopsy in AIDS cases for the last 15 years

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple ubiquitin conjugates are present in rat brain synaptic membranes and postsynaptic densities.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer beta amyloid deposition enhanced by apoE epsilon4 gene precedes neurofibrillary pathology in the frontal association cortex of nondemented senior subjects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The AIDS dementia complex: II. Neuropathology.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incarceration and the acquired immunodeficiency syndrome: autopsy results in Texas prison inmates

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin is a component of neurofibrillary tangles in a variety of neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradation of alpha-synuclein by proteasome

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in neurocognitive performance in a cohort of patients treated with HAART for 3 years.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteasome inhibition results in increased poly-ADP-ribosylation: implications for neuron death

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropathology and general autopsy findings in AIDS during the last 15 years

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axonal damage revealed by accumulation of beta-APP in HIV-positive individuals without AIDS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha synuclein in neurodegenerative disorders: murderer or accomplice?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV-associated neurologic disease incidence changes:: Multicenter AIDS Cohort Study, 1990-1998

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolysis in the myelopathy of acquired immunodeficiency syndrome: preferential loss of the C-8 component of myelin basic protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence of Abeta-protein deposition in the human medial temporal lobe.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurodegeneration: linking ubiquitin/proteasome pathway impairment with inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improvement in HIV-associated motor slowing after antiretroviral therapy including protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin and the molecular pathology of neurodegenerative diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin immunoreactivity of multiple polypeptides in rat brain synaptic membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolysis, caloric restriction and aging.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible involvement of proteasome inhibition in aging: implications for oxidative stress.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combination antiretroviral therapy improves psychomotor speed performance in HIV-seropositive homosexual men

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of proteasome inhibitors on the synaptic localization of Vesl-1S/Homer-1a proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and secretion of active alpha 1-antichymotrypsin by murine primary astrocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The relentless effects of the aging process on protein turnover

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein turnover and synthesis: relation to synaptic function

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autopsy findings in a human immunodeficiency virus-infected population over 2 decades: influences of gender, ethnicity, risk factors, and time

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vasculopathy and amyloid beta reactivity in brains of patients with acquired immune deficiency (AIDS).

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The proteasome and its function in the ageing process.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurochemical and neurogenetic correlates of Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress, aging and the proteasomal system

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pathogenesis of senile plaques

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin and synaptic dysfunction: ataxic mice highlight new common themes in neurological disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin-dependent proteolysis in neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The changing pattern of HIV neuropathology in the HAART era.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dendritic injury is a pathological substrate for human immunodeficiency virus-related cognitive disorders. HNRC Group. The HIV Neurobehavioral Research Center

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitination-dependent mechanisms regulate synaptic growth and function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Making the diagnosis of Alzheimer's disease. A primer for practicing pathologists.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/15204928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1080/13550280490279816

1 reference

Europe PubMed Central

7 December 2017

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0 references

1 reference

Europe PubMed Central

7 December 2017

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