Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation (Q24534094)

4

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author name string

C S Mason

1

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C J Springer

2

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R G Cooper

3

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C J Marshall

Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12

5

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language of work or name

English

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publication date

15 April 1999

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published in

The EMBO Journal

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volume

18

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page(s)

2137-48

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issue

8

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cites work

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Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

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Protein kinase C alpha activates RAF-1 by direct phosphorylation

24 March 2017

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The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

24 March 2017

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24 March 2017

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Activated Ras displaces 14-3-3 protein from the amino terminus of c-Raf-1

24 March 2017

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Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation

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PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

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Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

7 April 2017

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Activation of Raf as a result of recruitment to the plasma membrane

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Senescence of human fibroblasts induced by oncogenic Raf.

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Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes.

27 September 2017

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The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src.

27 September 2017

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Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

27 September 2017

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An intact Raf zinc finger is required for optimal binding to processed Ras and for ras-dependent Raf activation in situ

27 September 2017

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Control of the ERK MAP kinase cascade by Ras and Raf.

27 September 2017

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Binding of human immunodeficiency virus type 1 to CD4 induces association of Lck and Raf-1 and activates Raf-1 by a Ras-independent pathway

27 September 2017

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Negative regulation of Raf-1 by phosphorylation of serine 621.

27 September 2017

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Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylation

27 September 2017

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Ras-Raf complexes: analyses of complexes formed in vivo

27 September 2017

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Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase

27 September 2017

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The cysteine-rich region of raf-1 kinase contains zinc, translocates to liposomes, and is adjacent to a segment that binds GTP-ras.

27 September 2017

1 reference

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A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function

27 September 2017

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Activation of (His)6-Raf-1 in vitro by partially purified plasma membranes from v-Ras-transformed and serum-stimulated fibroblasts

27 September 2017

1 reference

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The Raf-1 serine/threonine protein kinase.

27 September 2017

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GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex

27 September 2017

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Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate

27 September 2017

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Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase

27 September 2017

1 reference

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Interleukin 2 regulates Raf-1 kinase activity through a tyrosine phosphorylation-dependent mechanism in a T-cell line

27 September 2017

1 reference

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Reversal of Raf-1 activation by purified and membrane-associated protein phosphatases

27 September 2017

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Interleukin 2 induces tyrosine phosphorylation and activation of p72-74 Raf-1 kinase in a T-cell line

27 September 2017

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Colony stimulating factor-1 (CSF-1) stimulates temperature dependent phosphorylation and activation of the RAF-1 proto-oncogene product

27 September 2017

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Regulation of tetradecanoyl phorbol acetate-induced responses in NIH 3T3 cells by GAP, the GTPase-activating protein associated with p21c-ras

27 September 2017

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Both p21ras and pp60v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase

27 September 2017

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Phosphorylation of Raf by ceramide-activated protein kinase

27 September 2017

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27 September 2017

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Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells.

27 September 2017

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Identification of the major phosphorylation sites of the Raf-1 kinase.

30 May 2018

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Inhibition by cAMP of Ras-dependent activation of Raf.

30 May 2018

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Functional mapping of the N-terminal regulatory domain in the human Raf-1 protein kinase

30 May 2018

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The raf oncogene is associated with a radiation-resistant human laryngeal cancer

30 May 2018

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Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptor

30 May 2018

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Insulin activates the Raf-1 protein kinase.

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171298

Insulin activates the kinase activity of the Raf-1 proto-oncogene by increasing its serine phosphorylation

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171298

Activation of c-Raf-1 by Ras and Src through different mechanisms: activation in vivo and in vitro

30 May 2018

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Cooperating oncogenes converge to regulate cyclin/cdk complexes.

29 November 2018

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Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation

29 November 2018

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Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C

29 November 2018

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12 December 2020

Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms

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12 December 2020

Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation

1 reference

12 December 2020

Membrane recruitment of Raf-1 is not the only function of Ras in Raf-1 activation

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12 December 2020

Erythropoietin induces Raf-1 activation and Raf-1 is required for erythropoietin-mediated proliferation

1 reference

12 December 2020

Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells

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12 December 2020

Identifiers

DOI

10.1093/EMBOJ/18.8.2137

1 reference

4749072

4749072

1 reference

1 reference

1 reference