Inhibition of poly(ADP-ribose) glycohydrolase (PARG) specifically kills BRCA2-deficient tumor cells (Q44735471)

5 December 2017

title

Inhibition of poly(ADP-ribose) glycohydrolase (PARG) specifically kills BRCA2-deficient tumor cells (English)

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5 December 2017

Catherine Fathers

1

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5 December 2017

Ross M Drayton

series ordinal

2

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5 December 2017

Svetlana Solovieva

series ordinal

3

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5 December 2017

Helen E Bryant

series ordinal

4

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5 December 2017

publication date

1 March 2012

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5 December 2017

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5 December 2017

volume

11

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5 December 2017

issue

5

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5 December 2017

page(s)

990-997

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Poly(ADP-ribose): novel functions for an old molecule

5 December 2017

cites work

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Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks

21 January 2018

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DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines

21 January 2018

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Poly(ADP-ribose) polymerase-1 (PARP-1) is required in murine cell lines for base excision repair of oxidative DNA damage in the absence of DNA polymerase beta

21 January 2018

1 reference

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Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase

21 January 2018

1 reference

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Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate

21 January 2018

1 reference

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Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining.

21 January 2018

1 reference

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PARP-3 and APLF function together to accelerate nonhomologous end-joining

21 January 2018

1 reference

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Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks

21 January 2018

1 reference

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PARP-1 ensures regulation of replication fork progression by homologous recombination on damaged DNA.

21 January 2018

1 reference

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PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination.

21 January 2018

1 reference

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A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage

21 January 2018

1 reference

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Spatial and temporal cellular responses to single-strand breaks in human cells.

21 January 2018

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APLF (C2orf13) is a novel component of poly(ADP-ribose) signaling in mammalian cells.

21 January 2018

1 reference

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

21 January 2018

1 reference

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

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Pathways of mammalian replication fork restart.

21 January 2018

1 reference

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The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase

21 January 2018

1 reference

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Radiation-induced mitotic catastrophe in PARG-deficient cells.

21 January 2018

1 reference

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Dual role of poly(ADP-ribose) glycohydrolase in the regulation of cell death in oxidatively stressed A549 cells

21 January 2018

1 reference

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Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice

21 January 2018

1 reference

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Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19482

Deletion of the nuclear isoform of poly(ADP-ribose) glycohydrolase (PARG) reveals its function in DNA repair, genomic stability and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19482

Mono-galloyl glucose derivatives are potent poly(ADP-ribose) glycohydrolase (PARG) inhibitors and partially reduce PARP-1-dependent cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19482

Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19482

Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19482

Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19482

A partial hprt gene duplication generated by non-homologous recombination in V79 Chinese hamster cells is eliminated by homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19482

Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19482

Synthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19482

AKT1 inhibits homologous recombination by inducing cytoplasmic retention of BRCA1 and RAD51.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19482

AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19482

DNA damage-induced protein 14-3-3 sigma inhibits protein kinase B/Akt activation and suppresses Akt-activated cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19482

Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19482

Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19482

Gallotannin inhibits NFĸB signaling and growth of human colon cancer xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19482

Poly(ADP-ribose) glycohydrolase inhibitor as chemosensitiser of malignant melanoma for temozolomide

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19482

Discovery and structure-activity relationships of modified salicylanilides as cell permeable inhibitors of poly(ADP-ribose) glycohydrolase (PARG).

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19482

Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19482

21 January 2018

Identifiers

DOI

10.4161/CC.11.5.19482

1 reference

5 December 2017

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