Functional role of Mdm2 phosphorylation by ATR in attenuation of p53 nuclear export (Q44679404)

5 December 2017

Functional role of Mdm2 phosphorylation by ATR in attenuation of p53 nuclear export (English)

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5 December 2017

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4

Koji Okamoto

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5 December 2017

Tomomi Shinozaki

1

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5 December 2017

Ayumi Nota

series ordinal

2

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5 December 2017

Yoichi Taya

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3

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5 December 2017

language of work or name

English

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publication date

1 December 2003

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5 December 2017

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5 December 2017

22

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5 December 2017

55

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5 December 2017

8870-8880

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1207176

5 December 2017

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cites work

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

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The many substrates and functions of ATM

21 January 2018

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Substrate specificities and identification of putative substrates of ATM kinase family members

21 January 2018

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A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

21 January 2018

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ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint

21 January 2018

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Akt enhances Mdm2-mediated ubiquitination and degradation of p53.

21 January 2018

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The IARC TP53 database: new online mutation analysis and recommendations to users

21 January 2018

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Activation of an MDM2-specific caspase by p53 in the absence of apoptosis

21 January 2018

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DNA replication blockade impairs p53-transactivation

21 January 2018

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Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

21 January 2018

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Cocompartmentalization of p53 and Mdm2 is a major determinant for Mdm2-mediated degradation of p53.

21 January 2018

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Cell cycle checkpoint signaling through the ATM and ATR kinases

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7 January 2021

Phosphorylation of HDM2 by Akt.

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7 January 2021

Stress signals utilize multiple pathways to stabilize p53

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7 January 2021

Enhanced phosphorylation of p53 by ATM in response to DNA damage

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7 January 2021

ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses

1 reference

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7 January 2021

mdm2 expression is induced by wild type p53 activity

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7 January 2021

Hypophosphorylation of Mdm2 augments p53 stability

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7 January 2021

An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.

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7 January 2021

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

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7 January 2021

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

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7 January 2021

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

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7 January 2021

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

1 reference

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7 January 2021

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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7 January 2021

A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

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7 January 2021

The MDM2 RING-finger domain is required to promote p53 nuclear export

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7 January 2021

The complexity of p53 modulation: emerging patterns from divergent signals

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7 January 2021

Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation

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7 January 2021

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

1 reference

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7 January 2021

Identification of p53 sequence elements that are required for MDM2-mediated nuclear export

1 reference

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7 January 2021

Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase

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7 January 2021

ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

1 reference

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7 January 2021

Hypoxia links ATR and p53 through replication arrest

1 reference

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7 January 2021

Multiple sites of in vivo phosphorylation in the MDM2 oncoprotein cluster within two important functional domains

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7 January 2021

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

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7 January 2021

Cancer. p53, guardian of the genome

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7 January 2021

MDM2--arbiter of p53's destruction

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207176

7 January 2021

p53, the cellular gatekeeper for growth and division

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207176

7 January 2021

Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207176

7 January 2021

C-terminal ubiquitination of p53 contributes to nuclear export

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207176

7 January 2021

A requirement for replication in activation of the ATR-dependent DNA damage checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207176

7 January 2021

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

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7 January 2021

MDM2--master regulator of the p53 tumor suppressor protein

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7 January 2021

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

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7 January 2021

Cyclin G recruits PP2A to dephosphorylate Mdm2

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207176

7 January 2021

Signaling to p53: breaking the MDM2-p53 circuit

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7 January 2021

Tumor surveillance via the ARF-p53 pathway.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207176

7 January 2021

Nuclear degradation of p53 occurs during down-regulation of the p53 response after DNA damage

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207176

7 January 2021

DNA damage induces phosphorylation of the amino terminus of p53

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207176

7 January 2021

Generation and application of phospho-specific antibodies for p53 and pRB

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207176

7 January 2021

A role for ATR in the DNA damage-induced phosphorylation of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207176

7 January 2021

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207176

7 January 2021

The p53-mdm-2 autoregulatory feedback loop

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207176

7 January 2021

A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207176

7 January 2021

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207176

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207176

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Dimensions Publication ID

5 December 2017

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