Levels of PTEN protein modulate Akt phosphorylation on serine 473, but not on threonine 308, in IGF-II-overexpressing rhabdomyosarcomas cells (Q44645813)

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scientific article published on November 6, 2003

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English	Levels of PTEN protein modulate Akt phosphorylation on serine 473, but not on threonine 308, in IGF-II-overexpressing rhabdomyosarcomas cells	scientific article published on November 6, 2003

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scholarly article

1 reference

Europe PubMed Central

5 December 2017

Levels of PTEN protein modulate Akt phosphorylation on serine 473, but not on threonine 308, in IGF-II-overexpressing rhabdomyosarcomas cells (English)

1 reference

Europe PubMed Central

5 December 2017

1 reference

based on heuristic

inferred from title

phosphorylation

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based on heuristic

inferred from title

rhabdomyosarcoma

1 reference

based on heuristic

inferred from title

1 reference

10.1038/SJ.ONC.1206878

https://api.crossref.org/works/10.1038/SJ.ONC.1206878

29 March 2024

author name string

Xiaolin Wan

1

1 reference

Europe PubMed Central

5 December 2017

Lee J. Helman

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14603261

29 March 2024

language of work or name

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publication date

1 November 2003

1 reference

Europe PubMed Central

5 December 2017

6 November 2003

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14603261

29 March 2024

full work available at URL

https://www.nature.com/articles/1206878.pdf

Portable Document Format

online access status

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14603261

29 March 2024

https://www.nature.com/articles/1206878.pdf

Portable Document Format

1 reference

10.1038/SJ.ONC.1206878

https://api.crossref.org/works/10.1038/SJ.ONC.1206878

29 March 2024

https://www.nature.com/articles/1206878

1 reference

10.1038/SJ.ONC.1206878

https://api.crossref.org/works/10.1038/SJ.ONC.1206878

29 March 2024

1 reference

Europe PubMed Central

5 December 2017

22

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Europe PubMed Central

5 December 2017

50

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Europe PubMed Central

5 December 2017

8205-8211

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Europe PubMed Central

5 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1206878

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Mechanism of activation and function of protein kinase B.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

21 January 2018

Ten years of protein kinase B signalling: a hard Akt to follow

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

21 January 2018

Two splice variants of protein kinase B gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site serine 472 in the carboxyl-terminal hydrophobic domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

21 January 2018

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

1 reference

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21 January 2018

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

1 reference

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21 January 2018

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

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21 January 2018

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

1 reference

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21 January 2018

Mechanisms and consequences of activation of protein kinase B/Akt

1 reference

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21 January 2018

Insulin-like growth factor II-mediated proliferation of human neuroblastoma

1 reference

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21 January 2018

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 reference

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21 January 2018

Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

1 reference

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21 January 2018

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

1 reference

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21 January 2018

Akt signaling: linking membrane events to life and death decisions

1 reference

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21 January 2018

Inhibition of protein kinase B/Akt. implications for cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

21 January 2018

PTEN: The down side of PI 3-kinase signalling.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

21 January 2018

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

21 January 2018

Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

21 January 2018

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

21 January 2018

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

21 January 2018

Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

21 January 2018

The protein kinase B/Akt signalling pathway in human malignancy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

21 January 2018

Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

21 January 2018

Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

21 January 2018

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

21 January 2018

Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

21 January 2018

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

21 January 2018

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

21 January 2018

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

21 January 2018

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

21 January 2018

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

21 January 2018

Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase

1 reference

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21 January 2018

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

21 January 2018

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

21 January 2018

Involvement of IGF-II in human cancer.

1 reference

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21 January 2018

Effect of insulin-like growth factor II on protecting myoblast cells against cisplatin-induced apoptosis through p70 S6 kinase pathway

1 reference

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21 January 2018

PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

21 January 2018

PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis.

1 reference

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21 January 2018

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

1 reference

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21 January 2018

Expression of insulin-like growth factor-II transcripts in Wilms' tumour

1 reference

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21 January 2018

PTEN transcriptionally modulates c-myc gene expression in human breast carcinoma cells and is involved in cell growth regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

7 January 2021

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PtdIns(3,4,5)P3 gets its message across

1 reference

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7 January 2021

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Dual regulation of platelet protein kinase B

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

A role for nuclear PTEN in neuronal differentiation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

7 January 2021

based on heuristic

inferred from DOI database lookup

PKB/AKT: functional insights from genetic models

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

7 January 2021

based on heuristic

inferred from DOI database lookup

Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206878

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanism of activation of protein kinase B by insulin and IGF-1

1

1 reference

10.1038/SJ.ONC.1206878

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Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

3

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Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors

16

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Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors

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Identifiers

10.1038/SJ.ONC.1206878

1 reference

Europe PubMed Central

5 December 2017

1 reference

Europe PubMed Central

5 December 2017

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